Inclusion Criteria:

- A participant must be 11 years of age or older and may be of any race, and gender;
participants between 4 and 10 years of age, inclusive, may be considered on a
site-by-site basis.

- A participant must have a diagnosis of histologically confirmed osteosarcoma or
Ewing's sarcoma;

- A participant with either:

- relapsed and resectable osteosarcoma

- relapsed and unresectable osteosarcoma that is refractory to standard therapy,
ie. has relapsed after prior systemic treatment with active chemotherapy agents

- Ewing's sarcoma that is refractory to standard systemic therapies

- A participant >16 years of age must have an Eastern Cooperative Oncology Group (ECOG)
performance status of <=2; a participant <=16 years of age must have a Karnofsky
performance status between 50% and 100% or a Lansky play scale between 50% and 100%

- A participant must have adequate organ function.

Exclusion Criteria:

- A participant with a history of another malignancy (with the exception of
non-melanoma skin cancer or carcinoma in situ of the cervix treated with curative
intent at least 2 years prior to start of treatment, or other adequately treated
malignancy for which the subject has been disease free for >=5 years)

- A participant who has known treated or untreated leptomeningeal metastasis, or a
metastatic central nervous system lesion

- A participant with a history of uncontrolled diabetes mellitus

- A participant with a recent myocardial infarction (within the past year); or a
participant who at the time of Screening presents with unstable or uncontrolled
angina, New York Heart Association (NYHA) Class III or IV congestive heart failure,
uncontrolled hypertension, clinically significant cardiac dysrhythmia or clinically
significant electrocardiogram (ECG) abnormality

- A participant with an active infection

- A participant with clinically significant hepatitis at Screening, or a participant
who is hepatitis C antibody positive, hepatitis B surface antigen positive, or human
immunodeficiency virus (HIV) seropositive

- A participant who has been treated with an anti-IGF-1R targeted drug or antibody

- A participant with known hypersensitivity to other antibodies, or any accompanying
excipients associated with these medications.