Inclusion Criteria:

- Advanced melanoma with life expectancy of at least 6 months.

- Melanoma must be considered unresectable.

- Patients with stable, treated brain mets must be stable clinically and
radiographically and off steroids for at least one month.

Exclusion Criteria:

- Patients must not be eligible for participation in any ongoing CP-675,206 clinical
studies currently open for enrollment.

- History of chronic inflammatory or autoimmune disease.

- History of inflammatory bowel disease, celiac disease, or other chronic
gastrointestinal conditions associated with diarrhea, active colitis, history of
diverticulitis.