Trial Information

Interindividual Genetic Variability as a Determinant of Chemotherapy Toxicity and Response in Pediatric Oncology/Bone Marrow Transplantation Patients

The title of this study is interindividual genetic variability as a determinant of
chemotherapy toxicity and response in pediatric oncology/bone marrow transplantation
patients. We will collect blood from pediatric oncology/bone marrow transplantation patients
who are going to receive chemotherapy in order to assess several defined genetic
polymorphisms that may be involved in chemotherapy toxicity and response. The polymorphisms
will be assessed on normal mononuclear cells by a combination of techniques. We will
determine whether these polymorphisms occur in pediatric oncology/bone marrow
transplantation patients and their correlation with different clinical features during and
following therapy including toxicity and response. The presence or absence of polymorphisms
will be correlated with patient outcome and tumor recurrence.