Inclusion Criteria:

- Written informed consent obtained prior to any study specific procedures

- Age ≥ 18 years

- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2

- Life expectancy of at least 3 months

- Able to comply with the protocol

- Histologically confirmed adenocarcinoma of the stomach or gastro-oesophageal junction
with inoperable, locally advanced or metastatic disease, not amenable to curative
therapy

- Measurable disease or non-measurable but evaluable disease, according to the Response
Evaluation Criteria in Solid Tumours (RECIST)

- Patient not receiving anticoagulant medication must have an International normalized
ratio (INR) ≤ 1.5 and activated partial thromboplastin time (aPTT) ≤ 1.5 x Upper
Limit of Normal (ULN) within 7 days prior to randomisation

Exclusion Criteria:

- Previous chemotherapy for locally advanced or metastatic gastric cancer. Patients may
have received prior neoadjuvant or adjuvant chemotherapy as long as it was completed
at least 6 months prior to randomisation

- Previous platinum or anti-angiogenic therapy (i.e. anti-VEGF or VEGFR tyrosine kinase
inhibitor etc)

- Patients with locally advanced disease who are candidates for curative therapy
(including operation and/or chemotherapy and/or radiotherapy)

- Radiotherapy within 28 days of randomisation

- Major surgical procedure, open biopsy or significant traumatic injury within 28 days
prior to randomisation, or anticipation of the need for major surgery during the
course of the study treatment (planned elective surgery)

- Minor surgical procedures within 2 days prior to randomisation

- Evidence of central nervous system (CNS) metastasis at baseline

- History or evidence upon physical/neurological examination of CNS disease unrelated
to cancer unless adequately treated with standard medical therapy, e.g. uncontrolled
seizures

- History of another malignancy which could affect compliance with the protocol or
interpretation of results

- Inadequate bone marrow function

- Inadequate liver function

- Inadequate renal function

- Uncontrolled hypertension or clinically significant (i.e. active) cardiovascular
disease

- Active infection requiring intravenous antibiotics at randomisation

- History or evidence of inherited bleeding diathesis or coagulopathy with the risk of
bleeding

- Serious or non-healing wound, peptic ulcer, or (incompletely healed) bone fracture

- Active gastrointestinal bleeding

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 6 months of randomisation

- Neuropathy (e.g. impairment of hearing and balance) ≥ grade II according to Common
Terminology Criteria for Adverse Events (CTCAE) v3.0

- Chronic daily treatment with aspirin or clopidogrel

- Chronic daily treatment with oral corticosteroids; inhaled steroids and short courses
of oral steroids for anti-emesis or as an appetite stimulant are allowed

- Known hypersensitivity to any of the study drugs or excipients or to Chinese hamster
ovary cell products or to other recombinant human or humanised antibodies

- Known dihydropyrimidine dehydrogenase (DPD) deficiency

- Evidence of any other disease, metabolic or psychological dysfunction, physical
examination finding, or clinical laboratory finding giving reasonable suspicion of a
disease or condition that contraindicates use of an investigational drug, or that may
affect patient compliance with the study, or place the patient at high risk from
treatment complications

- Known acute or chronic-active infection with Hepatitis B Virus (HBV) or Hepatitis C
Virus (HCV)

- Pregnant or lactating females

- Women of childbearing potential not using effective nonhormonal (intrauterine
contraceptive device, barrier method of contraception in conjunction with spermicidal
jelly or surgically sterile) means of contraception

- Sexually active men unwilling to practice contraception during the study

- Current or recent (within the 28 days prior to randomisation) treatment with another
investigational drug or participation in another investigational study