Inclusion Criteria:

1. Chronic pain greater than one year.

2. Male.

3. Cancer status must be stable or in remission. For this study, "stable disease" is
defined as identifiable disease at local or metastatic sites that has shown no
progression over the previous 3 months and there has been no cancer treatment for ³ 3
months.

4. Patients must be on chronic opioid therapy on a continuous basis in the preceding
twelve months with a Morphine Equivalent Daily Dose (MEDD) ³ 200.

5. Age >/= 18. The questionnaires used in this study have been validated only in the
adult population. In addition, some of the questionnaires contain questions of a
sensitive nature and are not appropriate in the pediatric population.

6. Patients must be able to understand and sign the consent form.

Exclusion Criteria:

1. Patient who refuses to participate in the study or determined incapable of completing
the research.

2. Patients with pre-existing hypopituitarism. Causes include certain tumors (pituitary
adenomas, hypothalamic tumors), inflammatory diseases (granulomatous diseases),
vascular diseases (postpartum necrosis, carotid aneurysm), traumatic/destructive
events (prior surgery, trauma, or radiation), developmental anomalies, infiltration.

3. Patients who tare taking any drugs that may affect the hypothalamic-pituitary-gonadal
axis.