Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
N/A
N/A
Both
Colonic Neoplasms
Trial Information
Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Patients with newly diagnoised colorectal cancer will be eligible. They will undergo
detailed history taking including family history, and molecular stuidies including
microsatellite instability test and immunohistochemistry for DNA mismatch repair protein
with pre-selection. Any abnormal finding in molecular stuides will be offered genetic
testing (after testing methylation status for patients with abnormalities in MLH1).
Inclusion Criteria:
- Colorectal cancer
Exclusion Criteria:
- Histology showing other than adenocarcinoma
Type of Study:
Observational
Study Design:
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal, Time Perspective: Prospective
Principal Investigator
Dong Kyung Chang, M.D. Ph.D
Investigator Role:
Principal Investigator
Investigator Affiliation:
Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
Authority:
South Korea: Institutional Review Board
Study ID:
SMC-2007-04-080
NCT ID:
NCT00516230
Start Date:
January 2006
Completion Date:
December 2011
Related Keywords:
- Colonic Neoplasms
- Colonic Neoplasms
- Lynch syndrome
- Neoplasms
- Colonic Neoplasms
- Colorectal Neoplasms
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