Differential Diagnosis Between Pancreatic Cancer and Chronic Pancreatitis: Value of the Detection of Urinary Cadmium
OBJECTIVES:
Primary
- Obtain urine samples and questionnaire data on cadmium exposure in patients with
chronic pancreatitis.
- Analyze these data to determine risk of pancreatic cancer using urine cadmium levels.
Secondary
- Analyze these data in conjunction with data on serum CA 19-9, to determine whether
urinary cadmium has clinical utility in predicting pancreatic cancer.
- Determine the sensitivity, specificity, and positive and negative predictive values for
the cadmium test alone, CA 19-9 alone, and both tests together.
OUTLINE: This is a pilot study.
Patients complete a questionnaire over approximately 20 minutes on lifetime exposure to
cadmium, including dietary, occupational, and recreational exposure, smoking history, and
residence. Patients also provide a urine sample that is analyzed by atomic absorption
spectrophotometry. Serum CA 19-9 levels are obtained from medical record if available.
Observational
Observational Model: Case Control, Time Perspective: Prospective
Exposure to cadmium, as measured by questionnaire data on dietary, occupational, and recreational exposure to cadmium, and by measurements of cadmium in urine
day 1
No
Gary G. Schwartz, MD, PhD, MPH
Study Chair
Comprehensive Cancer Center of Wake Forest University
United States: Institutional Review Board
CDR0000550074
NCT00489671
June 2003
August 2007
Name | Location |
---|