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A Phase 1 Study Evaluating A Second Generation Antisense Oligonucleotide (OGX 427) That Inhibits Heat Shock Protein 27 (Hsp27

Phase 1
18 Years
Open (Enrolling)

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Trial Information

A Phase 1 Study Evaluating A Second Generation Antisense Oligonucleotide (OGX 427) That Inhibits Heat Shock Protein 27 (Hsp27

This study is for patients with breast, prostate, ovarian, non-small cell lung (NSCL) or
bladder cancer who have failed potentially curative treatments or for whose disease a
curative treatment does not exist.

OGX-427 is a second-generation ASO that inhibits expression of Hsp27. Hsp27 is one of the
heat shock proteins. Hsp27 increases with cell stress, including cytotoxic chemotherapy,
radiation therapy and hormone therapy and has been shown to inhibit cell death. Thus,
decreasing Hsp27 as a cancer therapy is attractive as a therapy as it should result in down
regulation of pathways implicated in cancer progression and development of resistance to

A number of in vitro and in vivo pharmacological studies have demonstrated that OGX-427 has
single-agent activity in reducing Hsp27, inhibiting cell growth and inducing cell death in
several human cancer cell lines. OGX-427 has also demonstrated chemosensitizing activity in
studies using cell lines and animal models in combination with several cytotoxic drugs,
including docetaxel.

Docetaxel (Taxotere®) has anticancer activity in breast, prostate, ovarian, non-small cell
lung and bladder cancer. Docetaxel has been approved by Health Canada and the Food and Drug
Administration for the treatment of patients with breast, prostate, ovarian and non-small
cell lung cancer.

Inclusion Criteria

Inclusion Criteria

- Age ≥ 18 years at time of consent.

- Histologically or cytologically confirmed diagnosis of one of the following:
adenocarcinoma of the breast, ovary, or prostate, any NSCLC or bladder cancer.

- Must have metastatic disease. Prostate cancer patients must be hormone refractory.

- Must have failed therapies that are potentially curative; failed/refused standard
therapy known to prolong survival or progression-free survival; or failed/refused
therapy, that in the view of the investigator, would be beneficial in improvement of

- Patients enrolled into Cohorts 6 and 7 (OGX 427 in combination with docetaxel) must
have disease that has a possibility of responding to docetaxel.

- A minimum of 28 days must have elapsed between any major surgery, the last dose of
chemotherapy, radiotherapy (except limited fields-see #7 below), radioisotope,
immunotherapy or experimental agent and enrollment onto the study. Note: Patients on
hormone or estrogen therapy and steroids for treatment of their disease may remain on

- A minimum of 7 days must have elapsed between a single fraction of ≤ 800 cGy to a
limited field or conventional radiotherapy to a limited non marrow-bearing field such
as an extremity or orbit and enrollment onto the study.

- Recovery from all toxicities of prior therapy including chemotherapy, radiation
therapy, immunotherapy and experimental agents to ≤ grade 2 by NCI CTCAE, version

- If not treated with bilateral orchiectomy, patients with HRPC must be willing to
continue luteinizing hormone releasing hormone (LHRH) analogues throughout the study.

- If taking opioid medication, patient must be willing to continue on the same opioid
medication that they are on at enrollment through the PK/ECG evaluations during Cycle

- Karnofsky score of ≥60%.

- Various laboratory requirements.

- Must be willing to use effective contraception during and for 3 months following
treatment if of child bearing potential.

- Must be willing to undergo pharmacokinetic blood draws and frequent ECG monitoring on
Days 1 and 2 of Cycle 1.

- Must provide written, informed consent.

Exclusion Criteria

- More than three cytotoxic chemotherapy regimens.

- Current treatment with any anticancer agent including but not limited to trastuzumab,
aromatase inhibitors, or tamoxifen. Steroids, bisphosphonates and female hormone
replacement therapy are allowed.

- Documented central nervous system (CNS) metastasis or carcinomatous meningitis.

- For patients in Cohorts 6 and 7, prior history of a serious allergic reaction to
docetaxel; any chemotherapy containing Cremophor EL (used in drugs such as
cyclosporine, etoposide, teniposide); or polysorbate 80 (the diluent for docetaxel).

- Current pregnancy or lactation.

- Current second malignancy except for non melanoma skin cancers, superficial bladder
cancer, early cervical cancer or early prostate cancer not requiring treatment.

- Uncontrolled and/or serious medical conditions such as, but not limited to, active
infection, symptomatic congestive heart failure, unstable angina, significant cardiac
arrhythmia, significant neurological dysfunction, history of myocardial infarction or
stroke within the 3 months prior to enrollment or any other condition which the
Investigator feels would preclude protocol therapy.

- Concomitant participation in another clinical trial of an experimental drug, vaccine
or device.

- Prior high dose chemotherapy requiring stem cell rescue.

- Atrial fibrillation, left bundle branch block, or obligatory use of a cardiac

- Currently on a drug known to increase the QTc duration.

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

• To determine the maximum tolerated dose (MTD) of OGX-427 when administered as a single agent, up to a 1000 mg dose level.

Outcome Time Frame:

approximately 2 years

Safety Issue:


Principal Investigator

Kim Chi, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of British Columbia


United States: Food and Drug Administration

Study ID:




Start Date:

June 2007

Completion Date:

April 2013

Related Keywords:

  • Neoplasms
  • Antisense
  • Heat Shock Protein
  • Neoplasms



Seattle Cancer Care Alliance Seattle, Washington  98109