Inclusion Criteria:

1. Documentation of disease. Patients must have one of the following disease types:

- Diffuse large cell non-Hodgkin's lymphoma, mediastinal B-cell lymphoma, or
peripheral T-cell lymphoma that is:

- Primary refractory (achievement less than complete response)

- Relapsed and refractory (achievement less than a partial response) to at
least a single salvage therapy

- Relapsed or primary refractory Follicular lymphoma (FL) with a high FL
International Prognostic Index.

- Large cell transformation of lymphoma from a more indolent lymphoma (e.g.,
follicular, marginal zone, etc.)

- Mantle cell lymphoma that is:

- Primary Refractory (achievement less than complete response)

- Relapsed (regardless of chemosensitivity of relapsed disease)

2. Patients who received prior autologous stem cell transplantation are not eligible.

3. Patient age 18-70 years

4. Performance status ECOG 0-1

5. Required baseline laboratory values:

- LVEF > 45% corrected

- DLCO > 50% of predicted value (corrected for hemoglobin)

- Serum creatinine ≤ 2.0 mg/dl or estimated creatinine clearance of ≥60 ml/min

- Bilirubin < 1 x upper limit of normal value.

- AST and ALT < 1 x upper limit of normal value.

6. Signed written informed consent. Patient must be capable of understanding the
investigational nature of the investigational nature, potential risks and benefits of
the study, and able to provide valid informed consent

Exclusion Criteria:

1. No active infection. Patients with active infections requiring oral or intravenous
antibiotics are not eligible for enrollment until resolution of infection.

2. No HIV disease. Patients with immune dysfunction are at a significantly higher risk
of infection from intensive immunosuppressive therapies.

3. Non-pregnant and non-nursing. Treatment under this protocol would expose a fetus to
significant risks. Women of childbearing potential should have a negative pregnancy
test prior to study entry. Women and men of reproductive potential should agree to
use an appropriate method of birth control throughout their participation in this
study due to the teratogenic potential of the therapy utilized in this trial.
Appropriate methods of birth control include oral contraceptives, implantable
hormonal contraceptives (Norplant®), or double barrier method (diaphragm plus
condom).