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High-Risk HPV Infections in Women Aged 25 to 65

25 Years
65 Years
Open (Enrolling)
Papillomavirus Infections

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Trial Information

High-Risk HPV Infections in Women Aged 25 to 65

Whether older women are susceptible to acquiring new, persistent high-risk (HR) HPV
infections from new sex partners is largely unknown. This is a pilot study of predictors of
HR HPV infections in two populations of women aged 25 to 44 and 45 to 65 who have used
internet dating websites in the past year. 400 women will be recruited and mailed kits for
self-collecting vaginal specimens for HPV DNA testing. Women will self-collect two sets of
vaginal specimens four months apart, and complete sexual behavior questionnaires at the time
of each self-collection. If new HPV infections associated with recent new partners are
detected in these women, this pilot data will be used to develop a larger longitudinal study
of the acquisition and natural history of HR HPV infections in older women. This information
is important for developing guidelines for HPV vaccine implementation and cervical cancer
screening guidelines in populations of older women.

Inclusion Criteria:

- Have had sex with men

- Have used the internet to search for romantic partners in the past year (e.g. posted
or responded to an ad on an internet dating website or social networking website)

Exclusion Criteria:

- Pregnant, breastfeeding, or planning a pregnancy in the next 6 months

- Hysterectomy

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

High-Risk HPV DNA

Outcome Time Frame:

four months

Safety Issue:


Principal Investigator

Rachel L Winer, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Washington


United States: Institutional Review Board

Study ID:




Start Date:

March 2007

Completion Date:

December 2008

Related Keywords:

  • Papillomavirus Infections
  • Papillomavirus Infections



University of Washington Seattle, Washington  98195