Inclusion Criteria:

- Histological diagnosis of relapsed or refractory classical HL

- Age >18 years

- Received and failed potentially curative chemotherapeutic regimens (e.g., ABVD,
Stanford V, or BEACOPP)

- Relapsed following autologous bone marrow transplantation (BMT), or are ineligible,
or refused BMT

- Completed radiotherapy, chemotherapy, and/or treatment with other investigational
agents at least 3 weeks prior to study entry

- Completed autologous BMT (if received) at least 3 months prior to study entry;
completed allogeneic BMT (if received); at least 6 months prior to study entry

- Eastern Cooperative Oncology Group (ECOG) status of <2

- Life expectancy of >3 months

- Laboratory data:

- Platelet count >50,000/mm3

- Hemoglobin >9.0 g/dL (may be maintained by transfusion)

- Absolute neutrophil count >1000/mm3

- ALT/AST <2.5 times the upper limit of normal (ULN)

- Total bilirubin <1.5 times ULN

- Creatinine <1.5 mg/dL

- Female subjects of childbearing potential must have a negative serum pregnancy test
at screening; subjects must agree to use a medically appropriate form of birth
control from screening until 6 months after the last dose of study medication

- Ability to provide written informed consent

Exclusion Criteria:

- Any significant diseases (other than HL) or clinically significant findings,
including psychiatric and behavioral problems, medical history and/or physical
examination findings that would preclude the subject from participating in the study

- History or clinical evidence of cnetral nervous system (CNS) HL

- Received allogeneic BMT

- Received growth factor support or transfusions to achieve hematology entry criteria
(platelets, hemoglobin, absolute neutrophil count)

- Major surgery within 4 weeks prior to study entry

- Known hypersensitivity to recombinant proteins or any excipient contained in the drug
formulation

- Known history of another primary malignancy that has not been in remission for at
least 5 years. Non-melanoma skin cancer and cervical carcinoma in situ or squamous
intraepithelial lesions (e.g., cervical intraepithelial neoplasia [CIN] or prostatic
intraepithelial/intraductal neoplasia [PIN]) are allowed.

- Any active viral, bacterial, or systemic fungal infection within 4 weeks prior study
entry

- Known positive for human immunodeficiency virus (HIV), hepatitis B virus surface
antigen (HBsAg), or hepatitis C virus (HCV)

- Histry of significant chronic or recurrent infections requiring treatment

- Receiving systemic steroids exceeding 10 mg prednisone or equivalent, or unstable on
steroid medication, during the 3 weeks immediately preceding enrollment

- Pregnant or breast-feeding