Inclusion Criteria:

- Histologically confirmed adenocarcinoma of the breast at significant risk of distant
recurrence based on at least one of the following criteria:

- Involvement of at least one sentinel or axillary lymph node on routine
histologic examination; patients with negative sentinel nodes and negative
axillary nodes or involvement only demonstrated by immunohistochemistry are not
eligible unless they meet one of the other eligibility criteria below

- Estrogen receptor (ER) negative tumor >= 1 cm

- ER+ tumor >= 5 cm regardless of recurrence score

- ER+ tumor >= 1 cm but < 5 cm with a recurrence score >= 11; (patients enrolled
in the TAILORx trial are eligible)

- Patients must have completed definitive breast surgery including total mastectomy and
axillary dissection (modified radical mastectomy), total mastectomy and sentinel node
biopsy, breast conservation surgery and axillary dissection or breast conservation
surgery and sentinel node biopsy

- Planned post-lumpectomy radiation therapy required, including any of the following:

- Whole breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy prior to chemotherapy

- Margins of breast conservation surgery or mastectomy must be histologically free of
invasive breast cancer and ductal carcinoma in situ (DCIS); patients with resection
margins positive for lobular carcinoma in situ (LCIS) are eligible

- Time from last surgery for breast cancer (breast conservation surgery, mastectomy,
sentinel node biopsy, axillary dissection or re-excision of breast conservation
surgery margins) to planned treatment start date must be > 28 days and =< 84 days

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- Absolute neutrophil count >= 1,000/mm^3

- Platelet count >= 100,000/mm^3

- Bilirubin =< 1.5 mg/dL

- Aspartate transferase (AST) =< 2 times upper limit of normal(ULN)

- Creatinine =< 1.5 mg/dL

- Urine protein:creatinine ratio < 1.0 or 24-hour protein

- Partial thromboplastin time (PTT) =< 1.5 times ULN

- Left ventricle ejection fraction (LVEF) normal by echocardiogram (ECHO) or multigated
acquisition scan (MUGA)

- Patients who have undergone breast conservation surgery must receive radiation; prior
to randomization, the investigator must specify the planned radiation technique:

- Whole breast radiation (WBRT) after chemotherapy

- Accelerated partial breast radiation (APBI) after chemotherapy

- Accelerated partial breast radiation (APBI) prior to chemotherapy

- Post-mastectomy radiation therapy (RT) is required for all patients with a primary
tumor of >= 5 cm or involvement of 4 or more lymph nodes; post-mastectomy RT may be
administered at the investigator's discretion for all other mastectomy patients

- Patients with human epidermal growth factor receptor (HER)2 + (3+ by
immunohistochemistry [IHC] or fluorescent in situ hybridisation [FISH] ratio >= 2)
breast cancer are not eligible

- Patients with synchronous bilateral breast cancer (diagnosed =< 1 month) if the
higher TNM stage tumor meets the eligibility criteria for this trial

- Patients must not have clinical evidence of inflammatory disease or fixed axillary
nodes at diagnosis

- Patients must not have received prior cytotoxic chemotherapy or hormonal therapy for
this breast cancer; prior treatment with an anthracycline, anthracenedione or taxane
for any condition is not allowed

- Patients must not have had any major surgical procedure within 28 days of planned
treatment start date

- Patients may not have had placement of a vascular access device within 24 hours of
planned Day 1 of treatment

- Patients must not have clinically significant cardiovascular or cerebrovascular
disease, including:

Any history of

- Cerebrovascular disease including transient ischemic attack (TIA), stroke or
subarachnoid hemorrhage

- Ischemic bowel within the last 12 months

- Myocardial infarction

- Unstable angina

- New York Heart Association (NYHA) class II or greater congestive heart failure

- Grade II or greater peripheral vascular disease

- Uncontrolled hypertension defined as systolic blood pressure (SBP) > 160 or diastolic
blood pressure (DBP) > 90

- Uncontrolled or clinically significant arrhythmia

- Patients who require full-dose anticoagulation may enroll provided they meet the
following criteria:

- The patient must have an in-range International Normalized Ratio (INR) (usually
between 2 and 3) on a stable dose of warfarin or be on stable dose of low molecular
weight (LMW) heparin

- The patient must not have active bleeding or pathological conditions that carry high
risk of bleeding (e.g. varices)

- Patients must not have a bleeding diathesis, hereditary or acquired bleeding
disorder or coagulopathy

- Patients must not have a non-healing wound or fracture; patients with an
abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
within 6 months prior to randomization are not eligible

- Patients must not have hypersensitivity to paclitaxel or drugs using the vehicle
Cremophor, Chinese hamster ovary cell products or other recombinant human
antibodies

- Women must not be pregnant or breast-feeding due to the potential harmful
effects of bevacizumab on the developing fetus; all females of childbearing
potential must have a blood or urine test within 7 days prior to randomization
to rule out pregnancy

- Women of childbearing potential and sexually active males must use an accepted
and effective method of contraception