Phase 3 Study of Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery Versus Stereotactic Radiosurgery Alone for 1-4 Brain Metastases
Whole-Brain Radiation Therapy (WBRT) had been a mainstay in the treatment of brain
metastases. However, treatment strategy which rely on Stereotactic Radiosurgery (SRS) has
becoming popular in Japan. It is not well understood if the Whole-Brain Radiation Therapy
(WBRT) combined with Stereotactic Radiosurgery (SRS) resulted in improvements in survival,
brain tumor control, functional preservation rate, and frequency of neurologic death. In
orer to determine the role of WBRT, we conducted prospective randomized trial between
WBRT+SRS and SRS-alone for 1-4 brain metastatic patients.
Observational
Observational Model: Defined Population, Time Perspective: Longitudinal, Time Perspective: Prospective
Hidefumi Aoyama, MD, PhD
Principal Investigator
Hokkaido University School of Medicine
Japan: Institutional Review Board
JROSG99-1
NCT00406835
October 1999
April 2005
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