A Pilot Study Investigating Active Breathing Coordinator (ABC) to Reduce Radiation Dose to Normal Structures in Breast Cancer Patients
The Active Breathing Coordinator (ABC) allows for temporary and reproducible immobilization
of internal thoracic structures by monitoring the patient's breathing cycle and implementing
a breath hold at a predefined lung volume level. While ABC is FDA approved and commercially
available, only preliminary dosimetric data is available on a small number of patients with
breast cancer. There is some data using ABC for intrathoracic malignancies, which shows that
it is feasible and safe to use. ABC can be used to optimize the distance between chest wall,
heart and liver. This allows adequate treatment of the breast and underlying chest wall
while minimizing irradiated cardiac and liver volume.
Interventional
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Dosimetric Evaluation Magnitude of Reduction in Irradiated Normal Tissues
To evaluate the magnitude of reduction in irradiated normal tissues (heart and liver) when using the Active Breathing Coordinator (ABC) in breast patients, as compared to standard, free-breathing.
30 days post-treatment
No
Pramila Rani Anne, MD
Principal Investigator
Thomas Jefferson University
United States: Institutional Review Board
02U.282
NCT00328783
October 2002
October 2013
Name | Location |
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Thomas Jefferson University Hospital | Philadelphia, Pennsylvania 19131 |