CSF-1 and Other Cytokines in Human Endometrial Carcinogenesis
N/A
N/A
Female
Uterine Neoplasms, Endometrial Neoplasms
Trial Information
CSF-1 and Other Cytokines in Human Endometrial Carcinogenesis
These experiments, taken together, should critically determine if there is a role for the
CSF-1/ c-fms autocrine, endocrine, or paracrine loop in the progression of endometrial
adenocarcinoma. If so, alterations in this loop may provide novel medical therapies for
this disease. Additionally, these experiments will determine which are the predominant
cytokines expressed in these tumors, and will help the investigators to determine the role,
if any, these cytokines play in cancer cell growth and proliferation in relationship with
each other and within and outside of the estrogen-mediated pathways.
Inclusion Criteria:
- All patients undergoing hysterectomy, or who have endometrial cancer, and are under
routine surveillance.
- Patients may have received prior hormonal, cytotoxic chemotherapy, irradiation or
surgical therapy.
- Healthy post-menopausal and peri-menopausal women.
- A consent form must be signed by the patient prior to study entry.
Exclusion Criteria:
- Patients who do not have primary uterine corpus tumors.
- Patients with less than one gram of tumor tissue available to procurement.
Type of Study:
Observational
Study Design:
Observational Model: Case Control, Time Perspective: Prospective
Principal Investigator
Harriet Smith, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of New Mexico
Authority:
United States: Institutional Review Board
Study ID:
CSF-1
NCT ID:
NCT00250770
Start Date:
January 1998
Completion Date:
January 2022
Related Keywords:
- Uterine Neoplasms
- Endometrial Neoplasms
- Corpus Uteri
- Endometrium
- Cancer
- Neoplasms
- Endometrial Neoplasms
- Uterine Neoplasms
- Adenoma
Name | Location |
|---|---|
| University of New Mexico | Albuquerque, New Mexico 87131 |
