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Assessment of Plasma Ghrelin Levels in Patients With Pancreatic Cancer

18 Years
Open (Enrolling)
Pancreatic Cancer

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Trial Information

Assessment of Plasma Ghrelin Levels in Patients With Pancreatic Cancer

The primary outcome measure for this study is plasma ghrelin level, and the two primary
comparison are:

- Patients with cachexia versus patients without cachexia

- Patients with cachexia versus healthy controls

Inclusion Criteria:

- Histological or cytological proof of pancreatic adenocarcinoma

- The control are will include healthy age-matched patients without cancer

- The test arm will include patients with pancreatic cancer and they will divided into
two groups: those with and without weight loss

- Patients must have recovered from any major infections and/or surgical procedures

Exclusion Criteria:

- Patients with other serious medical illness like congestive heart failure, thyroid
disease,liver disease or renal failure - conditions that will alter their nutritional

- Patients on appetite stimulant and those receiving total parenteral nutrition

- Patients who have undergone gastrectomy or those who have gastric ulcers

- Patients receiving active chemotherapy

- No prior malignancy except for adequately treated basal cell or squamous cell skin
cancer, in situ cervical cancer or for which patient has been disease free for at
least five years.

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Retrospective

Outcome Measure:

To evaluate plasma ghrelin levels in patients with pancreatic cancer and compare with age matched controls

Outcome Time Frame:

prior to treatment

Safety Issue:


Principal Investigator

J Marc Pipas, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center


United States: Institutional Review Board

Study ID:

DMS 0405



Start Date:

April 2004

Completion Date:

June 2013

Related Keywords:

  • Pancreatic Cancer
  • Ghrelin
  • Pancreatic Neoplasms



Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center Lebanon, New Hampshire  03756