Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2)
Inclusion Criteria:
- Diagnosis of acute lymphoblastic leukemia (pro B, pre B, c-ALL or T-ALL), proved by
morphology and immunophenotyping
- Age > 55 yrs (no upper age limit)
- Written informed consent
Exclusion Criteria:
- Severe leukemia associated complications, not controllable before therapy onset e.g.
- life threatening infections as sepsis, pneumonia, hypoxia, shock, life threatening
bleeding)
- Severe comorbidity e.g.
- decompensated renal failure if not caused by leukemia with Creatinine > 2x ULN
- heart failure (NYHA II/IV), instable Angina, significant coronary stenosis
- hepatic insufficiency e.g. liver cirrhosis or chronic active hepatitis with bilirubin
> 1,5 x ULN and/or ASA, ALA, AP > 2,5 ULN
- decompensated metabolic disturbances (e.g. not controllable diabetes)
- severe obstructive or restrictive pulmonary disease with hypoxaemia
- Severe psychiatric illness or other circumstances which may compromise cooperation of
the patient
- Active second neoplasia
- HIV infection
- Severely reduced general condition
- Cytostatic pre-treatment of ALL
- Chemotherapy treatment of any other malignancy during the last 5 years
- Participation in other clinical trials interfering with the study therapy