Inclusion Criteria:

- Histologically confirmed recurrent, metastatic, or residual cancer with disease
confined mostly to the peritoneal cavity. Patients with asymptomatic
extra-peritoneal disease are eligible.

- Measurable or evaluable disease. Patients with malignant ascites or carcinomatosis
only (documented by cytology or during surgery) are eligible. Patients with ovarian
cancer and disease manifested only by an elevated CA-125 are also eligible.

- Adequate hepatic, renal, and bone marrow functions: bilirubin less than or equal to
2.0 mg/dl; creatinine less than or equal to 2.0 mg/dl, alkaline phosphatase less
than or equal to 3 x upper limit of normal (uln), AST or ALT less than or equal to 3
x uln; AGC greater than or equal to 1500, platelets greater than or equal to 100,000.

- SWOG performance status 0-2

- Fully recovered from acute toxicities from prior surgery, chemotherapy, or radiation
therapy.

- Patients must use an approved method of birth control.

Exclusion Criteria:

- Medical, social, or psychological factors which could prevent patient from receiving
treatment.

- Prior therapy with intra-peritoneal irinotecan

- Significant intra-peritoneal adhesions detected clinically or by prior surgical
exploration