Inclusion Criteria:

To be eligible for the study, patients must fulfill all of the following criteria:

1. Patients must have the ability to give informed consent and have signed an approved
informed consent form.

2. Patients must have a pathologic diagnosis of soft tissue sarcoma or bony sarcoma.

3. Patients with tumor tissue available for assessment of EGFR status performed by
immunohistochemistry (IHC).

4. Patients with Zubrod performance status 0-2.

5. Patients must be 16 years of age or older.

6. Patients, 16 years or older, must either be not of child bearing potential or have a
negative pregnancy test within 7 days of treatment. Patients are considered not of
child bearing potential if they are surgically sterile (they have undergone a
hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are
postmenopausal.

7. If patients are childbearing or have child-fathering potential, they must use barrier
contraception during intercourse while being treated on this study.

8. Bone marrow function: absolute neutrophil count (ANC) 1,000/ul; platelets 75,000/l.

9. Renal function: creatinine 2.0 x institutional upper limit of normal (ULN).

10. Hepatic function: bilirubin 2.5 x ULN; AST 5.0 x ULN.

11. Patients must have received at least one systemic chemotherapy treatment or else
refuse to be treated with cytotoxic therapy.

12. Twenty-eight days or more should have elapsed since the patient has received any
prior systemic therapy.

13. Patients must have documented symptomatic or radiologic progression to their
preceding therapy.

14. For patients treated with prior radiation, 21 days or more should have elapsed since
the administration of the last fraction of radiation therapy and patients must have
recovered from all associated toxicities.

15. Patients must have measurable disease. The measurable lesion should be outside
previously irradiated fields or have documented progression at least 6 weeks after
completion of radiation.

Exclusion Criteria:

Any of the following criteria will make the patient ineligible to participate in this
study:

1. Acute hepatitis or known HIV.

2. Active or uncontrolled infection.

3. Significant history of uncontrolled cardiac disease i.e., uncontrolled hypertension,
unstable angina, recent myocardial infarction (within prior 6 months), uncontrolled
congestive heart failure, and cardiomyopathy with decreased ejection fraction.

4. Prior therapy which specifically and directly targets the EGFR pathway.

5. Prior severe infusion reaction to a monoclonal antibody.

6. Any concurrent chemotherapy not indicated in the study protocol or any other
investigational agent(s).

7. Other active systemic malignancy within the past year.