Inclusion Criteria:

- Adult patients with refractory or relapsed multiple myeloma, ECOG performance status
0-2 (ECOG)

- Adequate bone marrow reserve

- Adequate hepatic and renal function

- Ability to swallow capsules

- 3 weeks or more from prior chemotherapy and have recovered from prior toxicities

Exclusion Criteria:

- Patients who plan to go for bone marrow transplant within 4 weeks of start of
treatment

- Patients with prior treatment with other investigational agents with a similar
anti-tumor mechanism

- Patients with other active/uncontrolled clinically significant illnesses

- Pregnant or nursing female patients