Know Cancer

forgot password

Caloric Restriction and Aging in Humans

Phase 1
50 Years
60 Years
Not Enrolling

Thank you

Trial Information

Caloric Restriction and Aging in Humans

Animal studies suggest that caloric restriction (CR), or consuming fewer calories, increases
life span, and also protects against some aging-related disease processes such as
artherosclerosis and type II diabetes. However, it appears that simply burning more calories
through physical activity does not increase life span by itself. It is not known how CR
affects humans, but based on this evidence it appears that the reduced total intake and
metabolism of food is the main factor, rather than increased exercise alone.

To test this, volunteers will be placed on a program of either 20% caloric restriction or
20% increase of energy expenditure by exercise, or in a control group to be instructed in
healthy living. All will be evaluated on a number of potential markers of aging, on body
composition, and on risk factors for artherosclerosis and diabetes.

Participation in the study will last for 12 months. The Diet group will receive individual
instruction from a registered dietician. The Exercise group will be given an individualized
exercise program created by a personal trainer. The Healthy Lifestyle group will be given
information on how to make healthier choices; both diet and activity will be discussed. All
participants will be measured every two weeks, and will keep daily food and activity logs.
All will be seen by a physician and will have lab tests done before beginning the study, at
1 month, and then 3 month intervals.

Inclusion Criteria:

- Age 50 to 60

- Women must be post-menopausal

- Normal weight to moderately overweight, (Body Mass Index [BMI] between 23 - 30)

- In good health, free of major chronic diseases or conditions

- Well motivated

- Reliable

Exclusion Criteria:

- Major chronic disease or condition that would interfere with exercise or caloric
restriction (such as diabetes, coronary artery disease, significant obstructive
airway disease, stroke, resting blood pressure over 170 mmHg systolic and/or 100 mmHg
diastolic, history or evidence of malignancy, orthopedic or musculoskeletal problems)

- Hormone replacement therapy (DHEA, estrogen, thyroid, testosterone)

- Regular exercise twice or more per week

- Smoking

- Alcoholism

- Frequent travel

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention

Principal Investigator

John O. Holloszy, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University in St. Louis, School of Medicine


United States: Federal Government

Study ID:




Start Date:

March 2002

Completion Date:

February 2006

Related Keywords:

  • Aging
  • Diet
  • Caloric Restriction
  • Exercise
  • Energy Metabolism
  • Primary Aging
  • Secondary Aging



Washington University in St. Louis, School of Medicine St. Louis, Missouri  63110