Inclusion Criteria:

- Histological diagnosis of infiltrating breast carcinoma, including infiltrating
ductal carcinoma, lobular carcinoma, medullary carcinoma, colloid, comedocarcinoma,
papillary, inflammatory carcinoma, signet ring carcinoma. The patient's pathology
must be reviewed and confirmed by Iowa Methodist Medical Center's or Mercy Medical
Center's Pathology Department.

- AJCC Stage IV (any T, any N, M1), metastatic, progressive or recurrent breast
carcinoma. Patients may not be eligible for other curative intent treatment (e.g.
surgical resection). Patients must have failed one salvage treatment.

- Eastern Cooperate Oncology Group Performance Status less than or equal to 2.

- Serum albumin greater than or equal to 3.0 gm/dL.

- Expected survival greater than or equal to 6 months.

- Subjects must have a negative serology for Hep B, C and HIV prior to entering study.

- Adequate organ function including: Marrow: Hemoglobin greater than or equal to 10.0
mg/dL, absolute granulocyte count (AGC) greater than or equal to 1,500/mm(3),
platelets greater than or equal to 100,000/mm(3), absolute lymphocyte count greater
than or equal to 475/mm(3). Hepatic: serum total bilirubin less than or equal to 1.5
x upper limit of normal (ULN), ALT (SGPT) and AST (SGOT) less than or equal to 2.5 x
ULN. Renal: serum creatinine less than or equal to 1.5 x ULN or creatinine clearance
greater than or equal to 50 mL/min.

- All on-study tests must be less than or equal to Grade I toxicity for patient to be
eligible for study, excluding serum LDH levels. PT, PTT must be less than or equal to
1.5 x ULN except for patients who are on therapeutic anticoagulant therapy.

- Measurable or non-measurable disease as defined as:

Measurable - those that can be accurately measured in at least one dimension (longest
diameter to be recorded) as greater than or equal to 20 mm with conventional techniques
(CT, MRI, x-ray) or as greater than or equal to 10 mm with spiral CT scan. All tumor
measurements must be recorded in millimeters (or decimal fractions of centimeters).

Non-measurable - All other lesions (or sites of disease), including small lesions (longest
diameter less than 20 mm with conventional techniques or less than 10 mm using spiral CT
scan), are considered non-measurable disease. Bone lesions, leptomeningeal disease,
ascites, pleural or pericardial effusions, lymphangitis cutis or pulmonis, inflammatory
breast disease, abdominal masses (not followed by CT or MRI), and cystic lesions are all
considered non-measurable.

- Prior therapy for breast cancer that may include surgery, radiation therapy, and/or
less than or equal to 2 different cytotoxic chemotherapy regimens (including
neoadjuvant and adjuvant treatment). Patients receiving preoperative (neoadjuvant)
and postoperative (within 12 weeks of surgery) adjuvant chemotherapy with the same
agent(s) will be considered to have received a single chemotherapy regimen.

Patients with previously treated, unresponsive or progressive disease that have failed at
least one salvage regimen.

- Patients must be greater than or equal to 4 weeks since major surgery, radiotherapy,
chemotherapy (6-weeks if they were treated with a nitrosourea or mitomycin) and
recovered from the toxicity of prior treatment to less than or equal to Grade 1,
exclusive of alopecia or fatigue.

- Patients must have the ability to understand the study, its risks, side effects,
potential benefits and is able to give written informed consent to participate.
Patients may not be consented by a durable power of attorney (DPA).

- Male and female subjects of child producing potential must agree to use contraception
or avoidance of pregnancy measures while enrolled on study and receiving the
experimental drug, and for one month after the last immunization.

EXCLUSION CRITERIA:

- Age less than 18-years-old.

- Active CNS metastases or carcinomatous meningitis.

- Hypercalcemia greater than 2.9 mmol/L, unresponsive to standard therapy (e.g., I.V.
hydration, diuretics, calctonin and/or bisphosphate therapy).

- Pregnant or nursing women due to the unknown effects of vaccination on the developing
fetus or newborn infant.

- Other malignancy within five years, unless the probability of recurrence of the prior
malignancy is less than 5%. Patient's curatively treated for squamous and basal cell
carcinoma of the skin and carcinoma in situ of the uterine cervix (CIN) or patients
with a history of malignant tumor in the past that have been disease free for at
least five years are also eligible for this study.

- History of organ transplant or current active immunosuppressive therapy (such as
cyclosporine, tacrolimus, etc.) or history of prior immunotherapy except Herceptin
and/or other monoclonal antibody therapies.

- Subjects taking systemic corticosteroid therapy for any reason including replacement
therapy for hypoadrenalism, are not eligible. Subjects receiving inhaled or topical
corticosteroids are eligible. Subjects who require systemic corticosteroids after
beginning vaccinations, will be removed from the study.

- Significant or uncontrolled congestive heart failure (CHF), myocardial infarction,
significant ventricular arrhythmias within the last six months or significant
pulmonary dysfunction.

- Active infection or antibiotics within 1-week prior to study, including unexplained
fever (temp. greater than 38.1 degrees Celsius).

- Autoimmune disease (e.g., systemic lupus erythematosis, active rheumatoid arthritis,
etc). Patients with a remote history of asthma or mild active asthma are eligible.

- Other serious medical conditions that may be expected to limit life expectancy to
less than 2 years (e.g., liver cirrhosis).

- Any condition, psychiatric or otherwise, that would preclude informed consent
consistent follow-up or compliance with any aspect of the study (e.g., untreated
schizophrenia or other significant cognitive impairment, etc).

- A known allergy to any component of the alpha (1,3) galactosyltransferase tumor
vaccine or cell lines from which it is derived.

- Patients having undergone splenectomy.