Inclusion Criteria:

- Histologically confirmed classical Hodgkin's lymphoma

- No bone marrow biopsies or fine needle aspirates as the sole means of diagnosis

- Core biopsies allowed if they contain adequate tissue for primary diagnosis

- The following subtypes are allowed:

- Nodular sclerosis

- Lymphocyte rich

- Mixed cellularity

- Lymphocyte depletion

- Classical Hodgkin's lymphoma, not otherwise specified

- No nodular lymphocyte-predominant Hodgkin's lymphoma

- Relapsed or refractory disease after at least 1 prior standard systemic cytotoxic
chemotherapy regimen

- Measurable disease by physical exam or imaging studies

- Any tumor mass > 1 cm is allowed

- No non-measurable disease only, including the following:

- Bone lesions

- Ascites

- Pleural or pericardial effusion

- Lymphangitis cutis/pulmonis

- Bone marrow

- No curative option available with high-dose therapy and stem cell transplantation

- Performance status - 0-2

- Absolute neutrophil count ≥ 750/mm^3

- Platelet count ≥ 75,000/mm^3

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST ≤ 2.5 times ULN

- Creatinine ≤ 2.5 mg/dL

- No sensory or motor peripheral neuropathy ≥ grade 2

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for up to 3 months after
study participation

- See Disease Characteristics

- Prior stem cell transplantation allowed

- See Disease Characteristics

- No concurrent chemotherapy

- No concurrent dexamethasone or other steroidal antiemetics

- Concurrent steroids for adrenal failure allowed

- Concurrent hormonal therapy for non-disease related conditions (e.g., insulin for
diabetes) allowed

- Prior radiotherapy to a symptomatic lesion or one that may produce disability (e.g.,
unstable femur) is allowed provided other measurable disease is present

- No concurrent palliative radiotherapy

- Recovered from all prior treatment

- No prior bortezomib or other proteosome inhibitors