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A Randomized Phase III Trial of Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) With or Without Cetuximab (C225) After Curative Resection for Patients With Stage III Colon Cancer

Phase 3
18 Years
69 Years
Open (Enrolling)
Adenocarcinoma of the Colon, Stage III Colon Cancer

Thank you

Trial Information

A Randomized Phase III Trial of Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) With or Without Cetuximab (C225) After Curative Resection for Patients With Stage III Colon Cancer


I. Compare the disease-free survival of patients with curatively resected stage III colon
cancer treated with adjuvant irinotecan (irinotecan hydrochloride) vs oxaliplatin with
fluorouracil and leucovorin calcium vs both regimens given consecutively (all
irinotecan-containing treatment arms are closed to accrual as of 6/1/2005).

II. Compare the disease-free survival of patients treated with these regimens with vs
without cetuximab.


I. Compare the overall survival of patients treated with these regimens. II. Compare the
disease-free and overall survival of patients whose tumors express epidermal growth factor
receptor treated with these regimens.

III. Compare the toxic effects of these regimens in these patients. IV. Compare the quality
of life, measures of patient satisfaction, nutrition, and cancer risk in patients treated
with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
positive lymph node involvement (1-3 vs 4 or more), histology (high [poorly differentiated
or undifferentiated] vs low [well to moderately differentiated]), and clinical T stage (T1
or T2 vs T3 vs T4). Patients are randomized to 1 of 6 treatment arms (as of 6/1/2005,
patients are randomized to treatment arms I and IV only; arms II, III, V, and VI are closed
to accrual).

ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours, leucovorin calcium IV
over 2 hours, and fluorouracil IV continuously over 46-48 hours on days 1. Treatment repeats
every 14 days for up to 12 courses in the absence of unacceptable toxicity or recurrent

ARM II (closed to accrual as of 6/1/2005--currently enrolled patients may cross over to arm
I for remainder of therapy): Patients receive irinotecan hydrochloride IV over 2 hours on
day 1 and leucovorin calcium and fluorouracil as in arm I. Treatment repeats every 14 days
for up to 12 courses in the absence of unacceptable toxicity or recurrent disease.

ARM III (closed to accrual as of 6/1/2005--currently enrolled patients may cross over to arm
I for remainder of therapy): Patients receive the same treatment as in arm I for 6 courses
followed by the same treatment as in arm II for 6 courses (total of 12 courses). Treatment
continues in the absence of unacceptable toxicity or recurrent disease.

ARM IV: Patients receive cetuximab* IV over 1 hour on days 1 and 8 and oxaliplatin,
leucovorin calcium, and fluorouracil as in arm I. Treatment repeats every 14 days for up to
12 courses in the absence of unacceptable toxicity or recurrent disease.

ARM V (closed to accrual as of 6/1/2005--currently enrolled patients may cross over to arm
IV for remainder of therapy): Patients receive cetuximab* as in arm IV and irinotecan
hydrochloride, leucovorin calcium, and fluorouracil as in arm II. Treatment repeats every 14
days for up to 12 courses in the absence of unacceptable toxicity or recurrent disease.

ARM VI (closed to accrual as of 6/1/2005--currently enrolled patients may cross over to arm
IV for remainder of therapy): Patients receive cetuximab* as in arm IV and chemotherapy as
in arm III.

NOTE: *Cetuximab is administered over 2 hours at a higher dose on day 1 of course 1 only.

Quality of life is assessed at baseline, before course 6, and at the end of therapy.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually for 3 years.

Inclusion Criteria:

- Histologically confirmed adenocarcinoma of the colon

- Stage III disease

- No resected stage IV disease

- No rectal cancer

- Gross inferior (caudad) margin of the primary tumor must be ≥ 12 cm from the
anal verge by rigid proctoscopy

- Stage III tumor must have been completely resected within the past 56 days

- Must have documented en bloc resection in patients with tumor adherence to
adjacent structures

- Tumor-related obstructions and colonic perforation are allowed

- Tumor samples must be available

- At least 1 pathologically confirmed positive lymph node

- No evidence of residual involved lymph node disease

- Synchronous primary colon cancer allowed

- No distant metastatic disease

- Performance status - ECOG 0-2

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin ≥ 9 g/dL

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- Creatinine ≤ 1.5 times ULN

- No uncontrolled high blood pressure

- No unstable angina

- No symptomatic congestive heart failure

- No myocardial infarction with the past 6 months

- No New York Heart Association class III or IV heart disease

- No symptomatic pulmonary fibrosis

- No symptomatic interstitial pneumonitis

- No prior allergic reaction (known sensitivity) to chimerized or murine monoclonal
antibody therapy

- No known allergy to platinum compounds

- No documented presence of human anti-mouse antibodies (HAMA)

- No active uncontrolled bacterial, viral, or systemic fungal infection

- HIV negative

- No clinically defined AIDS

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 2 months after study

- No inadequately treated gastrointestinal bleeding

- No ≥ grade 2 pre-existing peripheral sensory or motor neuropathy

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, carcinoma in situ of the cervix, or lobular carcinoma in
situ in 1 breast

- No other concurrent medical condition that would preclude study participation

- No concurrent biologic therapy

- No concurrent oprelvekin

- No concurrent pegfilgrastim

- No prior chemotherapy for colon cancer

- No other concurrent chemotherapy

- No prior radiotherapy for colon cancer

- No concurrent targeted agents

- No prior agents directed against epidermal growth factor-receptor

- No concurrent ketoconazole or other potent inhibitors of CYP3A4 (e.g., itraconazole
or voriconazole)

- No other concurrent anticancer therapy

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free survival, defined as the time from surgery until the time to tumor recurrence of death, whichever is first

Outcome Description:

Estimated by the method of Kaplan and Meier.

Outcome Time Frame:

At 5 years

Safety Issue:


Principal Investigator

Frank Sinicrope

Investigator Role:

Principal Investigator

Investigator Affiliation:

North Central Cancer Treatment Group


United States: Food and Drug Administration

Study ID:




Start Date:

February 2004

Completion Date:

Related Keywords:

  • Adenocarcinoma of the Colon
  • Stage III Colon Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Colonic Neoplasms



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Princeton Community Hospital Princeton, West Virginia  24740
Mount Carmel Regional Cancer Center Pittsburg, Kansas  66762
Peninsula Cancer Institute Newport News, Virginia  23601
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Memorial Health University Medical Center Savannah, Georgia  31404
Community Medical Center Scranton, Pennsylvania  18510
Clarian Arnett Cancer Care Lafayette, Indiana  47904
University of Chicago Comprehensive Cancer Center Chicago, Illinois  60637-1470
University of Southern California Los Angeles, California  90033
DeKalb Medical Center Decatur, Georgia  30033
Olathe Medical Center Olathe, Kansas  
Northern Indiana Cancer Research Consortium South Bend, Indiana  
Nevada Cancer Institute Las Vegas, Nevada  89135
Clearview Cancer Institute Huntsville, Alabama  35805
Riverside Middle Peninsula Cancer Center Gloucester, Virginia  23061
Hawaii Medical Center East Honolulu, Hawaii  96817
Hematology Oncology Associates Albuquerque, New Mexico  87106
The Community Hospital Munster, Indiana  46321
North Broward Medical Center Dearfield Beach, Florida  33064-3596
OSF Saint Francis Medical Center Peoria, Illinois  61637
Northside Hospital Atlanta, Georgia  30342
Western Regional CCOP Phoenix, Arizona  85006
Phoenix Indian Medical Center Phoenix, Arizona  85016
Scottsdale Healthcare Scottsdale, Arizona  85251
Highlands Oncology Group-Bentonville Bentonville, Arkansas  72712
Saint Edward Mercy Medical Center Ft. Smith, Arkansas  72903
Veteran's Administration Medical Center Little Rock, Arkansas  72205
Alta Bates Medical Center-Herrick Campus Berkeley, California  94704
Mills - Peninsula Hospitals Burlingame, California  94010
Valley Medical Oncology Consultants-Castro Valley Castro Valley, California  94546
Eden Hospital Medical Center Castro Valley, California  94546
Northbay Cancer Center Fairfield, California  94533
Valley Medical Oncology Consultants-Fremont Fremont, California  94538
Kaiser Permanente, Fremont Fremont, California  94538
California Cancer Center - North Fresno Fresno, California  93720
California Cancer Care - Greenbrae Greenbrae, California  94904
Kaiser Permanente, Hayward Hayward, California  94545
Fremont - Rideout Cancer Center Marysville, California  95901
Community Hospital of Monterey Peninsula Monterey, California  93940
Palo Alto Medical Foundation-Camino Division Mountain View, California  94040
Bay Area Breast Surgeons Inc Oakland, California  94609
Bay Area Tumor Institution CCOP Oakland, California  94609
Tom K Lee Inc Oakland, California  94609
Kaiser Permanente-Oakland Oakland, California  94611
Saint Joseph Hospital Orange, California  92868
Palo Alto Medical Foundation Heath Care Palo Alto, California  94301
Valley Medical Oncology Consultants Pleasanton, California  94588
Valley Care Health System - Pleasanton Pleasanton, California  94588
Kaiser Permanente-Redwood City Redwood City, California  94063
Kaiser Permanente-Richmond Richmond, California  94801
Kaiser Permanente-Roseville Roseville, California  95661
Sutter General Hospital Sacramento, California  95816
Kaiser Permanente-South Sacramento Sacramento, California  95823
Kaiser Permanente - Sacramento Sacramento, California  95825
University of California San Diego - Veterans Administration San Diego, California  92161
Naval Medical Center -San Diego San Diego, California  92134
Kaiser Permanente-San Francisco San Francisco, California  94115
University of California San Francisco Medical Center-Mount Zion San Francisco, California  94115
Kaiser Permanente-Santa Teresa-San Jose San Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo, California  94806
Kaiser Permanente-San Rafael San Rafael, California  94903
Santa Rosa Memorial Hospital Sana Rosa, California  95405
Kaiser Permanente-Santa Rosa Santa Rosa, California  95403
Kaiser Permanente-South San Francisco South San Francisco, California  94080
Kaiser Permanente-Stockton Stockton, California  95210
Kaiser Permanente-Vallejo Vallejo, California  94589
Kaiser Permanente-Walnut Creek Walnut Creek, California  94596
The Medical Center of Aurora Aurora, Colorado  80012
Penrose-Saint Francis Healthcare Colorado Springs, Colorado  80907
Memorial Hospital Colorado Springs Colorado Springs, Colorado  80909
Saint Anthony Central Hospital Denver, Colorado  80204
Exempla Saint Joseph Hospital Denver, Colorado  80218
Colorado Cancer Research Program CCOP Denver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Mary Corwin Medical Center Pueblo, Colorado  81004
Danbury Hospital Danbury, Connecticut  06810
Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
Middlesex Hospital Middletown, Connecticut  06457
The Hospital of Central Connecticut New Britain, Connecticut  06050
Stamford Hospital Stamford, Connecticut  06904
Bayhealth Medical Center at Kent General Dover, Delaware  19901
Lombardi Comprehensive Cancer Center at Georgetown University Washington, District of Columbia  20057
Halifax Medical Center-Centers for Oncology Daytona Beach, Florida  32114
Edna Williams Cancer Center at the Baptist Cancer Institute Jacksonville, Florida  32207
The Watson Clinic Lakeland, Florida  33805
Cancer Centers of Central Florida PA Leesburg, Florida  34788
Integrated Community Oncology Network - Orange Park Cancer Center Orange Park, Florida  32073
M D Anderson Cancer Center- Orlando Orlando, Florida  32806
Sacred Heart Medical Oncology Group - Davis Highway Pensacola, Florida  32514
Montgomery and Associates MD PA Saint Augustine, Florida  32086
Martin Memorial Hospital - South Stuart, Florida  34997
Martin Memorial Medical Center - North Stuart, Florida  34994
Palm Beach Cancer Institute-Main Office West Palm Beach, Florida  33401
Phoebe Putney Memorial Hospital Albany, Georgia  31703
Atlanta Regional CCOP Atlanta, Georgia  30342
Augusta Oncology Associates PC Augusta, Georgia  30901
Well Star Cobb Hospital Austell, Georgia  30106
John B Amos Cancer Center Columbus, Georgia  31904
Veterans Administration Medical Center Decatur, Georgia  30033
Wellstar Kennestone Hospital Marietta, Georgia  30060
Saint Joseph's-Candler Health System Savannah, Georgia  31405
Oncare Hawaii Inc-POB II Honolulu, Hawaii  96813
Oncare Hawaii Inc-Kuakini Honolulu, Hawaii  96817
University of Hawaii Honolulu, Hawaii  96813
Pacific Cancer Institute of Maui Wailuku, Hawaii  96793
Saint Luke's Mountain States Tumor Institute Boise, Idaho  83712
Saint Anthony's Health Alton, Illinois  62002
Rush - Copley Medical Center Aurora, Illinois  60504
John H Stroger Jr Hospital of Cook County Chicago, Illinois  60612-3785
Resurrection Healthcare Chicago, Illinois  60631
Saint Anthony Memorial Hospital Effingham, Illinois  62401
Cancer Institute at Alexian Brothers Elk Grove Village, Illinois  60007
Saint Francis Hospital Evanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystem Evanston, Illinois  60201
Intercommunity Cancer Center Galesburg, Illinois  61401
Hopedale Medical Complex - Hospital Hopedale, Illinois  61747
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Midwest Center for Hematology Oncology Joliet, Illinois  60432
Provena Saint Mary's Hospital Kankakee, Illinois  60901
North Shore Hematology Oncology Libertyville, Illinois  60048
Vigliotti, Antonio, P.G. M.D. (UIA Investigator) Moline, Illinois  61265
Stoffel, Thomas J MD (UIA Investigator) Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator) Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator) Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator) Moline, Illinois  61265
Good Samaritan Regional Medical Center Mt. Vernon, Illinois  62864
Edward Hospital Naperville, Illinois  60566
Hematology Oncology Consultants Limited Naperville, Illinois  60540
Cancer Care and Hematology Specialists of Chicagoland PC Niles, Illinois  60714
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
West Suburban Cancer Center River Forest, Illinois  60305
Sarah Culbertson Memorial Hospital Rushville, Illinois  62681
Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois  60076
Midwest Cancer Research Group Incorporated Skokie, Illinois  60077
Edward H Kaplan MD and Associates Skokie, Illinois  60076
Saint Margaret's Hospital Spring Valley, Illinois  61362
Carle Foundation dba Carle Cancer Center Urbana, Illinois  61801
Carle Clinic-Urbana Main Urbana, Illinois  61801
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana  46845
Richard L. Roudebush Veterans Affairs Medical Center Indianapolis, Indiana  46202
Wishard Hospital Indianapolis, Indiana  46202
Saint Vincent Hospital and Health Services Indianapolis, Indiana  46260
Howard Regional Healthcare System Kokomo, Indiana  46904
Premier Oncology Hematology Associates Merrillville, Indiana  46410
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
Saint Joseph's Medical Center South Bend, Indiana  46617
McFarland Clinic Ames, Iowa  50010
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Constantinou, Costas L MD (UIA Investigator) Bettendorf, Iowa  52722
Cedar Rapids Oncology Association Cedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLC Cedar Rapids, Iowa  52402
Mercy Hospital Cedar Rapids, Iowa  52403
Saint Luke's Hospital Cedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa  50325
Genesis Medical Center - East Campus Davenport, Iowa  52803
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Capitol Des Moines, Iowa  50307
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Finley Hospital Dubuque, Iowa  52001
Mercy Medical Center - North Iowa Mason City, Iowa  50401
Burgess Memorial Hospital Onawa, Iowa  51040
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Siouxland Hematology - Oncology Associates Sioux City, Iowa  51101
Covenant Medical Center Waterloo, Iowa  50702
Memorial Hospital of Arkansas City Arkansas City, Kansas  67005
Cancer Center of Kansas - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Radiation Oncology Practice Corporation Southwest Overland Park, Kansas  66210
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Stormont-Vail Regional Health Center Topeka, Kansas  66604
Saint Francis Hospital and Medical Center - Topeka Topeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Our Lady Bellefonte Hospital Ashland, Kentucky  41101
Merle Mahr Cancer Center Madisonville, Kentucky  42431
Ochsner Clinic Foundation-Baton Rouge Baton Rouge, Louisiana  70809
DeSoto Regional Health System Mansfield, Louisiana  71052
Metairie Oncologists Metairie, Louisiana  70006
Louisiana State University Sciences Center- Monroe Monroe, Louisiana  71210
Medical Center of Louisiana New Orleans, Louisiana  70112
Ochsner Clinic CCOP New Orleans, Louisiana  70121
Highland Clinic Shreveport, Louisiana  71105
The Union Memorial Hospital Baltimore, Maryland  21218
Washington County Hospital Hagerstown, Maryland  21740
Associates in Oncology Hematology PC -Kensington Kensington, Maryland  20895
Associates In Oncology Hematology PC-Rockville Rockville, Maryland  20878
Beverly Hospital Beverly, Massachusetts  01915
Caritas Saint Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Holyoke Medical Center Holyoke, Massachusetts  01040
Lawrence Memorial Medford, Massachusetts  02155
Holy Family Hospital Methuen, Massachusetts  01844
Metrowest Medical Center Incorporated Natick, Massachusetts  01760
Norwood Hospital Norwood, Massachusetts  02062
North Shore Medical Center Cancer Center Peabody, Massachusetts  01960
Berkshire Hematology Oncology PC Pittsfield, Massachusetts  01201
Commonwealth Hematology Oncology PC-Quincy Quincy, Massachusetts  02169
Morton Hospital and Medical Center Taunton, Massachusetts  02780
Hickman Cancer Center Adrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Michigan State University - Breslin Cancer Center East Lansing, Michigan  48824-1313
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
McLaren Regional Medical Center Flint, Michigan  48532
Spectrum Health-Blodgett Campus Grand Rapids, Michigan  49506
Grand Rapids Clinical Oncology Program Grand Rapids, Michigan  49503
Saint Mary's Health Care Grand Rapids, Michigan  49503
Spectrum Health at Butterworth Campus Grand Rapids, Michigan  49503
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Kalamazoo Center for Medical Studies Kalamazoo, Michigan  49008
Ingham Regional Medical Center Lansing, Michigan  48910
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mid-Michigan Medical Center - Midland Midland, Michigan  48670
Mercy Memorial Hospital Monroe, Michigan  48162
Mercy Health Partners-Mercy Campus Muskegon, Michigan  49443
Mercy Health Partners-Hackley Campus Muskegon, Michigan  49442
Northern Michigan Regional Hospital Petoskey, Michigan  49770
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Harris, John Gilbert MD (UIA Investigator) Alexandria, Minnesota  56308
Medini, Eitan MD (UIA Investigator) Alexandria, Minnesota  56308
Merit Care Clinic Bemidji Bemidji, Minnesota  56601
Brainerd Medical Center Inc Brainerd, Minnesota  56401
Saint Joseph's Medical Center Brainerd, Minnesota  56401
Saint Mary's Medical Center Duluth, Minnesota  55805
Miller-Dwan Hospital Duluth, Minnesota  55805
Saint Luke's Hospital of Duluth Duluth, Minnesota  55805
Duluth Clinic CCOP Duluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator) Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator) Fergus Falls, Minnesota  56537
Unity Hospital Fridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health System Mankato, Minnesota  56002
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
Minneapolis Veterans Medical Center Minneapolis, Minnesota  55417
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Saint Cloud Hospital Saint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Saint Joseph's Hospital - Healtheast Saint Paul, Minnesota  55102
Adult and Pediatric Urology PLLP Sartell, Minnesota  56377
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Veterans Affairs Medical Center Jackson, Mississippi  39216
Keesler Medical Center Kessler AFB, Mississippi  39534
Southeast Missouri Hospital Cape Girardeau, Missouri  63701
Saint John's Regional Medical Center Joplin, Missouri  64804
Freeman Health System Joplin, Missouri  64804
Kansas City Veterans Affairs Medical Center Kansas City, Missouri  64128
Radiation Oncology Practice Corporation - North Kansas City, Missouri  64154
Saint Luke's Cancer Institute Kansas City, Missouri  64111
Radiation Oncology Practice Corporation South Kansas City, Missouri  64114
Saint Luke's Hospital of Kansas City Kansas City, Missouri  64111
Saint Joseph Health Center Kansas City, Missouri  64114
Liberty Radiation Oncology Clinic Kansas City, Missouri  64116
Truman Medical Center Kansas City, Missouri  64108
Missouri Cancer Care PC - Saint Charles Saint Charles, Missouri  63301
Saint Anthony's Medical Center Saint Louis, Missouri  63128
Saint Louis-Cape Girardeau CCOP Saint Louis, Missouri  63141
Christian Hospital Northeast - Northwest Saint Louis, Missouri  63136
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Saint John's Mercy Medical Center Saint Louis, Missouri  63141
Saint Louis Cancer and Breast Institute Saint Louis, Missouri  63109
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Deaconess Medical Center Billings, Montana  59107
Billings Clinic Billings, Montana  59107-7000
Internal Medicine of Bozeman Bozeman, Montana  59715
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator) Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Community Medical Hospital Missoula, Montana  59801
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Saint Elizabeth Regional Medical Center Lincoln, Nebraska  68510
Lincoln Medical Education Foundation Cancer Resource Center Lincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOP Omaha, Nebraska  68106
Midlands Community Hospital Papillion, Nebraska  68046
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
Columbia Parkland Medical Center Derry, New Hampshire  03038
Exeter Hospital Exeter, New Hampshire  03833
New Hampshire Oncology Hematology Associates Hooksett, New Hampshire  03106
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene, New Hampshire  03431
LRGHealthcare-Lakes Region General Hospital Laconia, New Hampshire  03246
Elliot Hospital Manchester, New Hampshire  03103
Portsmouth Regional Hospital Portsmouth, New Hampshire  03802
Ocean Medical Center Brick, New Jersey  08724
Cooper Hospital University Medical Center Camden, New Jersey  08103
Veterans Adminstration New Jersey Health Care System East Orange, New Jersey  07018-1095
Hunterdon Medical Center Flemington, New Jersey  08822
Saint Barnabas Medical Center Livingston, New Jersey  07039
Mountainside Hospital Montclair, New Jersey  07042
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly, New Jersey  08060
Sparta Cancer Treatment Center Sparta, New Jersey  07871
South Jersey Healthcare Vineland, New Jersey  08360
Virtua West Jersey Hospital Voorhees Voorhees, New Jersey  08043
University of New Mexico at Lovelace Medical Center Albuquerque, New Mexico  87102
Presbyterian Kaseman Hospital Albuquerque, New Mexico  87110
Memorial Medical Center - Las Cruces Las Cruces, New Mexico  88011
The North Division of Montefiore Medical Center Bronx, New York  10466
Veterans Affairs Western New York Health Care System-Buffalo Buffalo, New York  14215
Adirondack Cancer Center Glens Falls, New York  12801
Orange Regional Medical Center Middletown, New York  10940
New York University Langone Medical Center New York, New York  10016
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division New York, New York  10025
Columbia University Medical Center New York, New York  10032
Interlakes Foundation Inc-Rochester Rochester, New York  14623
Highland Hospital Rochester, New York  14620
State University of New York Upstate Medical University Syracuse, New York  13210
Faxton-Saint Luke's Healthcare Utica, New York  13502
Dickstein Cancer Treatment Center White Plains, New York  10601
Mission Hospitals Inc Asheville, North Carolina  28801
Alamance Regional Medical Center Burlington, North Carolina  27216
Gaston Memorial Hospital Gastonia, North Carolina  28054
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina  28791
Kinston Medical Specialists PA Kinston, North Carolina  28501
Marion L Shepard Cancer Center Washington, North Carolina  27889
Saint Alexius Medical Center Bismarck, North Dakota  58501
Medcenter One Health Systems Bismarck, North Dakota  58501
Innovis Health South University Fargo, North Dakota  58103
Meritcare Hospital Fargo, North Dakota  58122
Veterans Administration Medical Center Fargo, North Dakota  58102
Summa Barberton Hospital Barberton, Ohio  44203
The Boardman Cancer Center Boardman, Ohio  44512
Aultman Health Foundation Canton, Ohio  44710
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Veteran Affairs Medical Center Dayton, Ohio  45428
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Cleveland Clinic Cancer Center Independence Independence, Ohio  44131
Cole, Sharon, K. M.D. (UIA Investigator) Kenton, Ohio  43326
Kettering Medical Center Kettering, Ohio  45429
Saint Rita's Medical Center Lima, Ohio  45801
Mansfield General Hospital-MedCentral Health System Mansfield, Ohio  44903
Marietta Memorial Hospital Marietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Bayview Oncology Associates Oregon, Ohio  43616
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Community Hospital Springfield Springfield, Ohio  45505
Flower Memorial Hospital Sylvania, Ohio  43560
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
The Toledo Hospital Toledo, Ohio  43606
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Saint Joseph Cancer Center Warren, Ohio  44484
Saint Ann's Hospital Westerville, Ohio  43081
Cleveland Clinic Wooster Specialty Center Wooster, Ohio  44691
Wright-Patterson Medical Center Wright-Patterson Afb, Ohio  45433-5529
Saint Elizabeth Hospital Medical Center Youngstown, Ohio  44501
Genesis HealthCare System Zanesville, Ohio  43701
Cancer Centers of Southwest Oklahoma Research - Lawton Lawton, Oklahoma  73505
Natalie W Bryant Cancer Center Tulsa, Oklahoma  74136
Legacy Good Samaritan Hospital and Medical Center Portland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer Center Portland, Oregon  97227
Providence Saint Vincent Medical Center Portland, Oregon  97225
Columbia River Oncology Program Portland, Oregon  97225
Salem Hospital Salem, Oregon  97309
Saint Luke's Hospital Bethlehem, Pennsylvania  18015
Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Ephrata Cancer Center Ephrata, Pennsylvania  17522
Geisinger South Wilkes Barre-Hazelton Cancer Center Hazleton, Pennsylvania  18201
Central PA Hematology-Medical Oncology Associates PC Lemoyne, Pennsylvania  17043
Riddle Hospital Media, Pennsylvania  19063
Aria Health-Torresdale Campus Philadelphia, Pennsylvania  19114
Pottstown Memorial Medical Center Pottstown, Pennsylvania  19464
Saint Joseph Medical Center Reading, Pennsylvania  19605
Guthrie Clinic - Sayre Sayre, Pennsylvania  18840
Hematology and Oncology Associates of North East Pennsylvania Scranton, Pennsylvania  18508
Scranton Hematology Oncology Scranton, Pennsylvania  18510
Mercy Hospital Scranton, Pennsylvania  18501
Associates In Hematology Oncology PC-Upland Upland, Pennsylvania  19013
Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania  18711
Mainline Health CCOP Wynnewood, Pennsylvania  19096
Hematology and Oncology Associates of Rhode Island Inc Cranston, Rhode Island  02920
Kent County Hospital Warwick, Rhode Island  02886
AnMed Health Hospital Anderson, South Carolina  29621
Greenville CCOP Greenville, South Carolina  29615
Greenville Memorial Hospital Greenville, South Carolina  29605
Upstate Carolina CCOP Spartanburg, South Carolina  29303
Conklin Regional Cancer Center Aberdeen, South Dakota  57401
Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota  57104
Sanford University of South Dakota Medical Center Sioux Falls, South Dakota  57117-5134
Tennessee Oncology PLLC- Centennial Medical Center Nashville, Tennessee  37203
The Don and Sybil Harrington Cancer Center Amarillo, Texas  79106
Texas Health Presbyterian Hospital Dallas Dallas, Texas  75231
The Center for Integrative Cancer Medicine El Paso, Texas  79902
Veterans Administration Medical Center Houston, Texas  77030
Saint Luke's Episcopal Hospital Houston, Texas  77030
South Texas Oncology and Hematology PA San Antonio, Texas  78229
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio San Antonio, Texas  78229
Audie L Murphy Veterans Affairs Hospital San Antonio, Texas  78209
University Hospital San Antonio, Texas  78229
Southwestern Oncology Research Department Bennington, Vermont  05201
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Peninsula Cancer Institute-Newport News Newport News, Virginia  23601
Southwest VA Regional Cancer Center Norton, Virginia  24273
Auburn Regional Medical Center Auburn, Washington  98002
Saint Joseph Hospital Bellingham, Washington  98225
Harrison Bremerton Hematology and Oncology Bremerton, Washington  98310
Saint Francis Hospital Federal Way, Washington  98003
Columbia Basin Hematology and Oncology PLLC Kennewick, Washington  99336
Evergreen Hospital Medical Center Kirkland, Washington  98033
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Minor and James Medical PLLC Seattle, Washington  98104
The Polyclinic Seattle, Washington  98122
Swedish Medical Center-First Hill Seattle, Washington  98122-4307
Holy Family Hospital Spokane, Washington  99207
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
Edwards Comprehensive Cancer Center Huntington, West Virginia  25701
West Virginia University Morgantown, West Virginia  26506
Wheeling Hospital Wheeling, West Virginia  26003
Langlade Hospital and Cancer Center Antigo, Wisconsin  54409
Mayo Clinic Health System Eau Claire Hospital - Luther Campus Eau Claire, Wisconsin  54703
Midelfort Clinic-Clairemont Campus Eau Claire, Wisconsin  54702
Sacred Heart Hospital Eau Claire, Wisconsin  54701
Central Wisconsin Cancer Program Fond Du Lac, Wisconsin  54935
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Aurora BayCare Medical Center Green Bay, Wisconsin  54311-6519
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
UW Health Oncology - 1 South Park Madison, Wisconsin  53715
Vince Lombardi Cancer Clinic-Marinette Marinette, Wisconsin  54143
Bay Area Medical Center Marinette, Wisconsin  54143
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Oconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Saint Michael's Hospital Stevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Marshfield Clinic-Wausau Center Wausau, Wisconsin  54401
Aspirus Regional Cancer Center Wausau, Wisconsin  54401