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A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma

Phase 3
18 Years
Open (Enrolling)
Kidney Cancer

Thank you

Trial Information

A Randomized Phase III Trial Of Interferon Alfa-2B Or Interferon Alfa-2B Plus Bevacizumab In Patients With Advanced Renal Carcinoma



- Compare the overall survival of patients with advanced renal cell carcinoma treated
with interferon alfa-2b alone or interferon alfa-2b with bevacizumab.


- Compare the time to disease progression and objective response rates in patients
treated with these regimens.

- Determine the toxicity of interferon alfa-2b in combination with bevacizumab in these

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to prior
nephrectomy (yes vs no) and number of risk factors for disease progression (0 vs 1-2 vs 3 or
more). Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients receive interferon alfa-2b subcutaneously (SC) three times a week.

- Arm II: Patients receive interferon alfa-2b as in arm I and bevacizumab IV over 30-90
minutes on days 1 and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

Patients are followed every 3 months for 2 years and then annually for up to 10 years after
study entry.

PROJECTED ACCRUAL: A total of 700 patients (350 per treatment arm) will be accrued for this
study within 3 years.

Inclusion Criteria


- Histologically or cytologically confirmed renal cell carcinoma (RCC)

- Conventional clear cell carcinoma

- Metastatic or unresectable disease

- The following characteristics and cellular types are excluded:

- True papillary

- Sarcomatoid features without a clear cell component

- Chromophobe

- Oncocytoma

- Collecting duct tumor

- Transitional cell carcinoma

- Measurable or nonmeasurable disease, including any of the following:

- Unidimensionally measurable lesion ≥ 20 mm by conventional techniques (e.g.,
physical exam or chest x-ray) OR 10 mm by spiral CT scan or MRI

- The following are considered nonmeasurable disease:

- Small lesions

- Bone lesions

- Leptomeningeal disease

- Ascites

- Pleural/pericardial effusion

- Lymphangitis cutis/pulmonis

- Abdominal masses that are not confirmed and followed by imaging techniques

- Cystic lesions

- Irradiated lesions, unless progression is documented after radiotherapy

- RCC paraffin tissue blocks or unstained slides must be available

- No evidence of prior or concurrent CNS metastases by MRI or CT scan



- 18 and over

Performance status

- Karnofsky 70-100%

Life expectancy

- Not specified


- Granulocyte count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- No history of clinically significant bleeding


- AST/ALT ≤ 2.5 times upper limit of normal (ULN)

- Alkaline phosphatase ≤ 2.5 times ULN

- Bilirubin ≤ 1.5 times ULN


- Creatinine ≤ 1.5 times ULN

- No proteinuria > 1+

- Proteinuria ≥ 2+ allowed provided protein is < 2 g/24-hour urine collection


- No deep venous thrombosis within the past year

- No cerebrovascular accident within the past year

- No peripheral vascular disease with claudication on < 1 block

- No uncontrolled hypertension defined as blood pressure ≥160 mm Hg (systolic) and/or ≥
90 mm Hg (diastolic) while on medication

- No New York Heart Association class II-IV congestive heart failure

- No angina pectoris requiring nitrate therapy

- No myocardial infarction within the past 6 months

- No other significant cardiovascular disease


- No pulmonary embolus within the past year

- No ongoing hemoptysis


- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 3 months after study

- No preexisting thyroid abnormality in which normal thyroid function cannot be
maintained by medication

- No delayed wound healing, ulcers, or bone fractures

- No uncontrolled psychiatric disorder

- No other currently active* malignancy except nonmelanoma skin cancer NOTE: *Disease
is not considered currently active if patient completed anticancer therapy and is
considered to have < 30% risk of relapse


Biologic therapy

- No prior systemic immunotherapy for RCC

- No prior thalidomide, anti-vascular endothelial growth factor (VEGF) therapy, VEGF
receptor inhibitors, or antiangiogenic treatment of any kind

- No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)


- No prior systemic chemotherapy for RCC

- No concurrent chemotherapy

Endocrine therapy

- No concurrent systemic corticosteroid therapy except the following:

- Topical and inhaled steroids

- Replacement therapy for adrenal insufficiency

- No concurrent hormones except those administered for nondisease-related conditions
(e.g., insulin for diabetes)


- See Disease Characteristics

- At least 4 weeks since prior radiotherapy and recovered

- Prior palliative radiotherapy to metastatic lesions allowed provided at least 1
measurable or nonmeasurable lesion remains untreated

- No concurrent palliative radiotherapy


- At least 4 weeks since prior major surgery and recovered


- No other prior systemic investigational therapy for RCC

- No other prior adjuvant or neoadjuvant systemic therapy for RCC

- No concurrent full-dose oral or parenteral anticoagulation* NOTE: *Low-dose (1 mg)
warfarin for maintenance of catheter patency and/or daily prophylactic aspirin is

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Overall Survival

Outcome Time Frame:

5 years

Safety Issue:


Principal Investigator

Brian I. Rini, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of California, San Francisco


United States: Food and Drug Administration

Study ID:




Start Date:

October 2003

Completion Date:

July 2015

Related Keywords:

  • Kidney Cancer
  • stage IV renal cell cancer
  • clear cell renal cell carcinoma
  • recurrent renal cell cancer
  • Carcinoma
  • Carcinoma, Renal Cell
  • Kidney Neoplasms



Roswell Park Cancer Institute Buffalo, New York  14263
Mayo Clinic - Jacksonville Jacksonville, Florida  32224
Mayo Clinic Cancer Center Rochester, Minnesota  55905
Walter Reed Army Medical Center Washington, District of Columbia  20307-5000
Emory University Hospital - Atlanta Atlanta, Georgia  30322
University of Chicago Cancer Research Center Chicago, Illinois  60637
Duke Comprehensive Cancer Center Durham, North Carolina  27710
Abington Memorial Hospital Abington, Pennsylvania  19001
CCOP - Upstate Carolina Spartanburg, South Carolina  29303
CCOP - Wichita Wichita, Kansas  67214-3882
Rhode Island Hospital Providence, Rhode Island  02903
Medical City Dallas Hospital Dallas, Texas  75230
CCOP - Atlanta Regional Atlanta, Georgia  30342-1701
CCOP - Kansas City Kansas City, Missouri  64131
CCOP - Missouri Valley Cancer Consortium Omaha, Nebraska  68131
CCOP - Southern Nevada Cancer Research Foundation Las Vegas, Nevada  89106
CCOP - Christiana Care Health Services Wilmington, Delaware  19899
CCOP - Mount Sinai Medical Center Miami Beach, Florida  33140
Veterans Affairs Medical Center - Atlanta (Decatur) Decatur, Georgia  30033
CCOP - Illinois Oncology Research Association Peoria, Illinois  61602
CCOP - Carle Cancer Center Urbana, Illinois  61801
CCOP - Iowa Oncology Research Association Des Moines, Iowa  50309-1016
Beth Israel Deaconess Medical Center Boston, Massachusetts  02215
CCOP - Metro-Minnesota Saint Louis Park, Minnesota  55416
Veterans Affairs Medical Center - East Orange East Orange, New Jersey  07018-1095
CCOP - Northern New Jersey Hackensack, New Jersey  07601
Bergan Mercy Medical Center Omaha, Nebraska  68124
Yale Comprehensive Cancer Center New Haven, Connecticut  06520-8028
Aurora Presbyterian Hospital Aurora, Colorado  80012
Boulder Community Hospital Boulder, Colorado  80301-9019
Penrose Cancer Center at Penrose Hospital Colorado Springs, Colorado  80933
Porter Adventist Hospital Denver, Colorado  80210
Presbyterian - St. Luke's Medical Center Denver, Colorado  80218
St. Joseph Hospital Denver, Colorado  80218
Rose Medical Center Denver, Colorado  80220
Swedish Medical Center Englewood, Colorado  80110
Sky Ridge Medical Center Lone Tree, Colorado  80124
Hope Cancer Care Center at Longmont United Hospital Longmont, Colorado  80502
North Suburban Medical Center Thornton, Colorado  80229
Rush-Copley Cancer Care Center Aurora, Illinois  60507
Carle Cancer Center at Carle Foundation Hospital Urbana, Illinois  61801
Saint Anthony Memorial Health Centers Michigan City, Indiana  46360
Cedar Rapids Oncology Associates Cedar Rapids, Iowa  52403
Mercy Medical Center - Sioux City Sioux City, Iowa  51104
St. Luke's Regional Medical Center Sioux City, Iowa  51104
CCOP - Michigan Cancer Research Consortium Ann Arbor, Michigan  48106
Genesys Hurley Cancer Institute Flint, Michigan  48503
Foote Hospital Jackson, Michigan  49201
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Seton Cancer Institute - Saginaw Saginaw, Michigan  48601
St. John Macomb Hospital Warren, Michigan  48093
Fairview Ridges Hospital Burnsville, Minnesota  55337
Fairview Southdale Hospital Edina, Minnesota  55435
Hutchinson Area Health Care Hutchinson, Minnesota  55350
Meeker County Memorial Hospital Lichfield, Minnesota  55355
Hennepin County Medical Center - Minneapolis Minneapolis, Minnesota  55415
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
CCOP - MeritCare Hospital Fargo, North Dakota  58122
St. Rita's Medical Center Lima, Ohio  45801
Natalie Warren Bryant Cancer Center at St. Francis Hospital Tulsa, Oklahoma  74136
Geisinger Medical Center Danville, Pennsylvania  17822-0001
Penn State Cancer Institute at Milton S. Hershey Medical Center Hershey, Pennsylvania  17033-0850
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center La Crosse, Wisconsin  54601
Marshfield Clinic - Marshfield Center Marshfield, Wisconsin  54449
Medical College of Wisconsin Cancer Center Milwaukee, Wisconsin  53226
CCOP - Ochsner New Orleans, Louisiana  70121
Rapid City Regional Hospital Rapid City, South Dakota  57709
Comprehensive Cancer Center at Wake Forest University Winston-Salem, North Carolina  27157-1082
Cancer Center at the University of Virginia Charlottesville, Virginia  22908
Memorial Hospital Cancer Center Colorado Springs, Colorado  80909
Halifax Medical Center Daytona Beach, Florida  32114
Methodist Medical Center of Illinois Peoria, Illinois  61636
Memorial Hospital of South Bend South Bend, Indiana  46601
CCOP - Montana Cancer Consortium Billings, Montana  59101
Elliot Regional Cancer Center Manchester, New Hampshire  03103
CCOP - Columbus Columbus, Ohio  43206
Veterans Affairs Medical Center - Dayton Dayton, Ohio  45428
CCOP - Dayton Kettering, Ohio  45429
Albert Einstein Cancer Center Philadelphia, Pennsylvania  19141
Mercy Hospital Cancer Center - Scranton Scranton, Pennsylvania  18501
CCOP - Greenville Greenville, South Carolina  29615
University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin  53792
CCOP - Northern Indiana CR Consortium South Bend, Indiana  46601
Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa  52242-1002
Cancer Center at Tufts - New England Medical Center Boston, Massachusetts  02111
UMASS Memorial Cancer Center - University Campus Worcester, Massachusetts  01605-2982
CCOP - Grand Rapids Grand Rapids, Michigan  49503
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756-0002
Cancer Institute of New Jersey at the Cooper University Hospital Camden, New Jersey  08103-1489
Long Island Cancer Center at Stony Brook University Hospital Stony Brook, New York  11790-7775
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina  27599-7570
MetroHealth's Cancer Care Center at MetroHealth Medical Center Cleveland, Ohio  44106
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Columbus, Ohio  43210-1240
CCOP - Columbia River Oncology Program Portland, Oregon  97225
CCOP - Scott and White Hospital Temple, Texas  76508
Cancer Research Center of Hawaii Honolulu, Hawaii  96813
St. Barnabas Medical Center Livingston, New Jersey  07039
MBCCOP - LSU Health Sciences Center New Orleans, Louisiana  70112
CCOP - St. Louis-Cape Girardeau Saint Louis, Missouri  63141
Veterans Affairs Medical Center - Albuquerque Albuquerque, New Mexico  87108-5138
Naval Medical Center - San Diego San Diego, California  92134-3202
Veterans Affairs Medical Center - San Francisco San Francisco, California  94121
Kaiser Permanente Medical Center - Vallejo Vallejo, California  94589
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. Syracuse, New York  13217
Veterans Affairs Medical Center - Minneapolis Minneapolis, Minnesota  55417
Rebecca and John Moores UCSD Cancer Center La Jolla, California  92093-0658
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California  95051-5386
University of New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico  87131
City of Hope Comprehensive Cancer Center Duarte, California  91010
Veterans Affairs Medical Center - San Diego San Diego, California  92161
UCSF Comprehensive Cancer Center San Francisco, California  94115
Fort Wayne Medical Oncology and Hematology, Incorporated Fort Wayne, Indiana  46885-5099
Fletcher Allen Health Care - University Health Center Campus Burlington, Vermont  05401
St. Mary's Medical Center Huntington, West Virginia  25701
John Stoddard Cancer Center at Iowa Methodist Medical Center Des Moines, Iowa  50309
Midlands Cancer Center at Midlands Community Hospital Papillion, Nebraska  68128-4157
Kaiser Permanente Medical Center - San Francisco Geary Campus San Francisco, California  94115
Medical Center of Central Georgia Macon, Georgia  31201
St. Vincent Mercy Medical Center Toledo, Ohio  43608
CCOP - Colorado Cancer Research Program, Incorporated Denver, Colorado  80224
Great Falls Clinic Great Falls, Montana  59405
Thompson Cancer Survival Center Knoxville, Tennessee  37916
Overlook Hospital Summit, New Jersey  07902-0220
Northside Hospital Cancer Center Atlanta, Georgia  30342-1611
Evanston Northwestern Health Care - Evanston Hospital Evanston, Illinois  60201
Fairview University Medical Center - University Campus Minneapolis, Minnesota  55455
Hulston Cancer Center at Cox Medical Center South Springfield, Missouri  65807
St. John's Regional Health Center Springfield, Missouri  65804
Carol G. Simon Cancer Center at Morristown Memorial Hospital Morristown, New Jersey  07962
Oklahoma University Medical Center Oklahoma City, Oklahoma  73104
Sioux Valley Hospital and University of South Dakota Medical Center Sioux Falls, South Dakota  57117-5134
Cancer Institute of New Jersey at Hamilton Hamilton, New Jersey  08690
Trinity Cancer Care Center Minot, North Dakota  58701
CCOP - Toledo Community Hospital Toledo, Ohio  43623-3456
St. Luke's Hospital Cancer Center Bethlehem, Pennsylvania  18015
Waukesha Memorial Hospital Regional Cancer Center Waukesha, Wisconsin  53188
Comprehensive Cancer Center at University of Alabama at Birmingham Birmingham, Alabama  35294
Kaiser Permanente Medical Center - Oakland Sacramento, California  95825
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center Savannah, Georgia  31403-3089
Via Christi Cancer Center at Via Christi Regional Medical Center Wichita, Kansas  67214
Ochsner Cancer Institute at Ochsner Clinic Foundation New Orleans, Louisiana  70121
CancerCare of Maine at Eastern Maine Medial Center Bangor, Maine  04401
Spectrum Health Cancer Care - Butterworth Campus Grand Rapids, Michigan  49503-2560
SUNY Upstate Medical University Hospital Syracuse, New York  13210
Mission Hospitals - Memorial Campus Asheville, North Carolina  28801
Presbyterian Cancer Center at Presbyterian Hospital Charlotte, North Carolina  28233-3549
Toledo Hospital Toledo, Ohio  43606
Greenville Hospital System Cancer Center Greenville, South Carolina  29605
Massey Cancer Center at Virginia Commonwealth University Richmond, Virginia  23298-0037
Providence Cancer Center at Sacred Heart Medical Center Spokane, Washington  99220-2555
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division Charleston, West Virginia  25302
Mary Babb Randolph Cancer Center at West Virginia University Hospitals Morgantown, West Virginia  26506
Lahey Clinic Medical Center - Burlington Burlington, Massachusetts  01805
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha Omaha, Nebraska  68114-4199
Aultman Hospital Cancer Center at Aultman Health Foundation Canton, Ohio  44710-1799
Hunterdon Regional Cancer Center at Hunterdon Medical Center Flemington, New Jersey  08822
Warren Hospital Phillipsburg, New Jersey  08865
Lewistown Hospital Lewistown, Pennsylvania  17044
Mount Nittany Medical Center State College, Pennsylvania  16803
Oncology Institute of Greater Lafayette Lafayette, Indiana  47904
Hematology Oncology Associates of the Quad Cities Bettendorf, Iowa  52722
St. Agnes Cancer Center Baltimore, Maryland  21229
Batte Cancer Center at Northeast Medical Center Concord, North Carolina  28025
Baptist Cancer Institute - Jacksonville Jacksonville, Florida  32207
Saint Anthony's Hospital at Saint Anthony's Health Center Alton, Illinois  62002
Siouxland Hematology-Oncology Associates Sioux City, Iowa  51101
Cancer Center of Kansas - Chanute Chanute, Kansas  66720
Cancer Center of Kansas - Dodge City Dodge City, Kansas  67801
Cancer Center of Kansas, P.A. - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas - Kingman Kingman, Kansas  67068
Southwest Medical Center Liberal, Kansas  67901
Cancer Center of Kansas - Newton Newton, Kansas  67114
Cancer Center of Kansas, P.A. - Parsons Parsons, Kansas  67357
Pratt Cancer Center of Kansas Pratt, Kansas  67124
Cancer Center of Kansas - Salina Salina, Kansas  67042
Cancer Center of Kansas - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, P.A. Wichita, Kansas  67208
Associates in Womens Health Wichita, Kansas  67203
Cancer Center of Kansas, P.A. - Wichita Wichita, Kansas  67214
Cancer Center of Kansas - Winfield Winfield, Kansas  67156
Mecosta County General Hospital Big Rapids, Michigan  49307
Metropolitan Hospital Grand Rapids, Michigan  49506
Lacks Cancer Center at Saint Mary's Mercy Medical Center Grand Rapids, Michigan  49503
Holland Community Hospital Holland, Michigan  49423
Hackley Hospital Muskegon, Michigan  49443
Northern Michigan Hospital Petoskey, Michigan  49770
William Beaumont Hospital - Royal Oak Campus Royal Oak, Michigan  48073
Munson Medical Center Traverse City, Michigan  49684
St. Francis Medical Center Cape Girardeau, Missouri  63701
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital Gape Girardeau, Missouri  63701
David C. Pratt Cancer Center at St. John's Mercy St. Louis, Missouri  63141
Sletten Regional Cancer Institute Great Falls, Montana  59405
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Adena Regional Medical Center Chillicothe, Ohio  54601
Doctors Hospital at Ohio Health Columbus, Ohio  43228
Riverside Methodist Hospital Cancer Care Columbus, Ohio  43214
Grant Riverside Cancer Services Columbus, Ohio  43215
Mount Carmel West Hospital Columbus, Ohio  43222
Grady Memorial Hospital Delaware, Ohio  43015
Fairfield Medical Center Lancaster, Ohio  43130
Strecker Cancer Center at Marietta Memorial Hospital Marietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark, Ohio  43055
Community Hospital of Springfield and Clark County Springfield, Ohio  45505
Mercy Medical Center Oncology Unit Springfield, Ohio  45504
Avera McKennan Hospital and University Health Center Sioux Falls, South Dakota  57105
Medical X-Ray Center Sioux Falls, South Dakota  57105
Lombardi Cancer Center at Georgetown University Medical Center Washington, District of Columbia  20007
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore, Maryland  21201
UNMC Eppley Cancer Center at the University of Nebraska Medical Center Omaha, Nebraska  68198-7680
Memorial Cancer Institute at Memorial Regional Hospital Hollywood, Florida  33021
Lenoir Memorial Cancer Center Kinston, North Carolina  28503-1678
Miriam Hospital at Lifespan Providence, Rhode Island  02906
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey  08903
Beth Israel Medical Center - Petrie Division New York, New York  10003-3803
Kaiser Permanente Medical Center - Sacramento Sacramento, California  95825
MBCCOP-Medical College of Georgia Cancer Center Augusta, Georgia  30912-4000
Mountain States Tumor Institute - Boise Boise, Idaho  83712
University of Illinois Medical Center Chicago, Illinois  60612
Dakota Cancer Institute at Innovis Health - Dakota Clinic Fargo, North Dakota  58103-4940
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas  75390-9063
Medcenter One Health System Bismarck, North Dakota  58501
Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois  61602
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital Greenville, North Carolina  27858-4354
Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois  62526
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
Elkhart General Hospital Elkhart, Indiana  46515
Florida Cancer Specialists Fort Myers, Florida  33901
Front Range Cancer Specialists Fort Collins, Colorado  80528
Lakeland Regional Cancer Center at Lakeland Regional Medical Center Lakeland, Florida  33805
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Joan Karnell Cancer Center at Pennsylvania Hospital Philadelphia, Pennsylvania  19107
Kaiser Permanente - Fremont Fremont, California  94538
Kaiser Permanente Medical Center - Hayward Hayward, California  94545
Kaiser Permanente Medical Center - Redwood City Redwood City, California  94063
Kaiser Permanente Medical Center - Richmond Richmond, California  94801
Kaiser Permanente Medical Center - Roseville Roseville, California  95661
South Sacramento Kaiser-Permanente Medical Center Sacramento, California  95823
Kaiser Permanente Medical Office -Vandever Medical Office San Diego, California  92120
Kaiser Permanente Medical Center - Santa Teresa San Jose, California  95119
Kaiser Foundation Hospital - San Rafael San Rafael, California  94903
Kaiser Permanente Medical Center - Santa Rosa Santa Rosa, California  95403
Kaiser Permanente Medical Center - South San Francisco South San Francisco, California  94080
Kaiser Permanente Medical Facility - Stockton Stockton, California  95210
Kaiser Permanente Medical Center - Walnut Creek Walnut Creek, California  94596
Poudre Valley Hospital Fort Collins, Colorado  80524
St. Mary-Corwin Regional Medical Center Pueblo, Colorado  81004
Beebe Medical Center Lewes, Delaware  19958
St. Francis Hospital Wilmington, Delaware  19805
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Fort Lauderdale, Florida  33308
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Jupiter, Florida  33458
Saint Joseph's Hospital of Atlanta Atlanta, Georgia  30342-1701
Piedmont Hospital Atlanta, Georgia  30309
WellStar Cobb Hospital Austell, Georgia  30106
Charles B. Eberhart Cancer Center at DeKalb Medical Center Decatur, Georgia  30033
Gwinnett Medical Center Lawrenceville, Georgia  30045
Kennestone Cancer Center at Wellstar Kennestone Hospital Marietta, Georgia  30060
Southern Regional Medical Center Riverdale, Georgia  30274-2600
St. Joseph Medical Center Bloomington, Illinois  61701
Graham Hospital Canton, Illinois  61520
Memorial Hospital Carthage, Illinois  62321
Galesburg Cottage Hospital Galesburg, Illinois  61401
Galesburg Clinic Galesburg, Illinois  61401
InterCommunity Cancer Center of Western Illinois Galesburg, Illinois  61401
Mason District Hospital Havana, Illinois  62644
Hopedale Medical Complex Hopedale, Illinois  61747
Kewanee Hospital Kewanee, Illinois  61443
McDonough District Hospital Macomb, Illinois  61455
Trinity Medical Center - East Moline, Illinois  61265
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Perry Memorial Hospital Princeton, Illinois  61356
St. Margaret's Hospital Spring Valley, Illinois  61362
Valley Cancer Center Spring Valley, Illinois  61362
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
St. Luke's Hospital Cedar Rapids, Iowa  52402
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Mercy Capitol Hospital Des Moines, Iowa  50307
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Burgess Health Center Onawa, Iowa  51040
St. Francis Comprehensive Cancer Center Topeka, Kansas  66606
Ochsner Clinic of Baton Rouge Baton Rouge, Louisiana  708169990
Mary Bird Perkins Cancer Center - Baton Rouge Baton Rouge, Louisiana  70809
Terrebonne General Medical Center Houma, Louisiana  70360
Union Hospital Cancer Center at Union Hospital Elkton MD, Maryland  21921
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital Ann Arbor, Michigan  48106-0995
Haematology-Oncology Associates of Ohio and Michigan, P.C. Lambertville, Michigan  48144
Community Cancer Center of Monroe Monroe, Michigan  48162
Mercy Memorial Hospital System Monroe, Michigan  48162
MeritCare Clinic - Bemidji Bemidji, Minnesota  56601
Brainerd Medical Center Brainerd, Minnesota  56401
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Chippewa County - Montevideo Hospital Montevideo, Minnesota  56265
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Hattiesburg Clinic, P.A. Hattiesburg, Mississippi  39401
Bryan LGH Medical Center West Lincoln, Nebraska  68502
St. Elizabeth Regional Medical Center Lincoln, Nebraska  68510
Great Plains Regional Medical Center North Platte, Nebraska  69101-6598
Kingsbury Center for Cancer Care at Cheshire Medical Center Keene, New Hampshire  03431
Frisbie Memorial Hospital Rochester, New Hampshire  03867
Charles R. Wood Cancer Center at Glens Falls Hospital Glens Falls, New York  12801
Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem, North Carolina  27103
Bismarck Cancer Center Bismarck, North Dakota  58501
MeritCare Medical Group Fargo, North Dakota  58122
Wood County Oncology Center Bowling Green, Ohio  43402
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
Good Samaritan Hospital Dayton, Ohio  45406
Blanchard Valley Medical Associates Findlay, Ohio  45840
Fremont Memorial Hospital Fremont, Ohio  43420
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
St. Charles Mercy Hospital Oregon, Ohio  43616
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Firelands Regional Medical Center Sandusky, Ohio  44870
Promedica Cancer Center at Flower Hospital Sylvania, Ohio  43560
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Surgical Specialists Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Fulton County Health Center Wauseon, Ohio  43567
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Comanche County Memorial Hospital Lawton, Oklahoma  73505
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Hematology and Oncology Associates Scranton, Pennsylvania  18510
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Mountainview Medical Berlin, Vermont  05602
Danville Regional Medical Center Danville, Virginia  24541
Virginia Oncology Associates - Hampton Hampton, Virginia  23666
Providence Cancer Center at Holy Family Hospital Spokane, Washington  99207
San Francisco General Hospital Medical Center San Francisco, California  94110
Eureka Hospital Eureka, Illinois  61530
Joliet Oncology Hematology Associates, Limited - West Joliet, Illinois  60435
Oncology Hematology Associates of Central Illinois - Ottawa Ottawa, Illinois  61350
Baton Rouge General Regional Cancer Center Baton Rouge, Louisiana  70821
Cancer Center at Medical Center of Louisiana - New Orleans New Orleans, Louisiana  70140-1015
Mercy Hospital Coon Rapids, Minnesota  55433
Mercy and Unity Cancer Center at Mercy and Unity Hospitals Fridley, Minnesota  55432-2799
Park Nicollet Clinic St. Louis Park, Minnesota  55416
Rose Ramer Cancer Clinic at Anderson Area Medical Center Anderson, South Carolina  29621
McFarland Clinic, P.C. Ames, Iowa  50010
Saint Anthony Regional Hospital Carroll, Iowa  51401
St. John's Hospital Maplewood, Minnesota  55109
Fremont Area Medical Center Fremont, Nebraska  68025-2387
Alegent Health - Immanuel Medical Center Omaha, Nebraska  68122
Mid Dakota Clinic, P.C. Bismarck, North Dakota  58501
Lancaster General Hospital Lancaster, Pennsylvania  17604-3555
Pottstown Memorial Regional Cancer Center Pottstown, Pennsylvania  19464
Geisinger Medical Group State College, Pennsylvania  16801
Geisinger Wyoming Valley Medical Center Wilkes-Barre, Pennsylvania  18711
Fox Valley Hematology and Oncology Appleton, Wisconsin  54911
Oconomowoc Memorial Hospital Oconomowoc, Wisconsin  53066
CCOP - Mayo Clinic Scottsdale Oncology Program Scottsdale, Arizona  85259
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Ft. Smith, Arkansas  72903
Providence Holy Cross Cancer Center Mission Hills, California  91346-9600
Middlesex Hospital Cancer Center Middletown, Connecticut  06457
Northeast Georgia Medical Center Gainesville, Georgia  30501
Swedish American Hospital Rockford, Illinois  61104
St. Francis Hospital and Health Centers Beech Grove, Indiana  46107
Saint Joseph Regional Medical Center - Plymouth Campus Plymouth, Indiana  46544
Mercy Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Alegent Health Mercy Hospital Council Bluffs, Iowa  51503
Wendt Regional Cancer Center at Finley Hospital Dubuque, Iowa  52001
Alegent Health Community Memorial Hospital Missouri Valley, Iowa  51555
Battle Creek Health System Battle Creek, Michigan  49017
Spectrum Health Hospital - Blodgett Campus Grand Rapids, Michigan  49506
Oncology Care Associates, P.L.L.C. Saint Joseph, Michigan  49085
Cancer Care Center at St. Luke's Hospital Duluth, Minnesota  55805
Cancer Care Center at Regions Hospital Saint Paul, Minnesota  55101
Saint Francis Cancer Center Shakopee, Minnesota  55379
St. Joseph's Hospital St Paul, Minnesota  55102
Adult and Pediatric Urology, P.L.L.P. St. Cloud, Minnesota  56303
Woodwinds Hospital Woodbury, Minnesota  55125
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Cancer Associates Columbia, Missouri  65201
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Cancer Center at the Good Samaritan Health Systems Kearney, Nebraska  68847
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Cancer Center at Creighton University Medical Center Omaha, Nebraska  68131
Washoe Cancer Services at Washoe Medical Center - Reno Reno, Nevada  89502
Cancer Center at the Mountainside Hospital Montclair, New Jersey  07042
Hematology-Oncology Associates, PC Albuquerque, New Mexico  87106
Lovelace Medical Center at Lovelace Sandia Health System Albuquerque, New Mexico  87108
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital Cooperstown, New York  13326
Randolph Hospital Asheboro, North Carolina  27203
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital Eden, North Carolina  27288
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
Akron City Hospital at Summa Health System Akron, Ohio  44304
University Hospitals Ireland Cancer Center at Mercy Medical Center Canton, Ohio  44708
Miami Valley Hospital Dayton, Ohio  45409
Medical College of Ohio Cancer Institute Toledo, Ohio  43614
Toledo Clinic, Incorporated Toledo, Ohio  43623
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital Allentown, Pennsylvania  18105
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
Guthrie Medical Center - Sayre Sayre, Pennsylvania  18840
All Saints Cancer Center at All Saints Healthcare Racine, Wisconsin  53405
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Green Bay, Wisconsin  54311
Vince Lombardi Cancer Clinic - Sheboygan Sheboygan, Wisconsin  53081
St. Francis Medical Center Honolulu, Hawaii  96817
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Watson Clinic Lakeland, Florida  33805
St. Joseph Hospital Regional Cancer Center - Orange Orange, California  92868-3849
Phoebe Cancer Center at Phoebe Putney Memorial Hospital Albany, Georgia  31702
Comprehensive Cancer Center at Our Lady of Mercy Medical Center Bronx, New York  10466
Queen's Cancer Institute at Queen's Medical Center Honolulu, Hawaii  96813
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Rutherford Hospital Rutherfordton, North Carolina  28139
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
MedCentral - Mansfield Hospital Mansfield, Ohio  44903
Cancer Care and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405-6013
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
New Mexico Cancer Care Associates Santa Fe, New Mexico  87505-7670
Mercy Health Center Oklahoma City, Oklahoma  73120
Central Pennsylvania Hematology and Medical Oncology Associates, PC Lemoyne, Pennsylvania  17043
Palm Beach Cancer Institute - West Palm Beach West Palm Beach, Florida  33401
Huntsville Hospital Huntsville, Alabama  35807
La Grange Memorial Hospital La Grange, Illinois  60525
PinnacleHealth Regional Cancer Center at Polyclinic Hospital Harrisburg, Pennsylvania  17105
Florida Oncology Associates Orange Park, Florida  32073
Lipson Cancer and Blood Center at Rochester General Hospital Rochester, New York  14621
Marshall University Medical Center Huntington, West Virginia  25701
Rappahannock General Hospital Kilmarnock, Virginia  22482
South Carolina Oncology Associates Columbia, South Carolina  29201
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Kapiolani Medical Center at Pali Momi Aiea, Hawaii  96701
Kapiolani Medical Center for Women and Children Honolulu, Hawaii  96826
Straub Clinic and Hospital, Incorporated Honolulu, Hawaii  96813
OnCare Hawaii, Incorporated - Kuakini Honolulu, Hawaii  96817
OnCare Hawaii, Incorporated - Lusitana Honolulu, Hawaii  96813
Iowa Blood and Cancer Care Cedar Rapids, Iowa  52402
Faxton Regional Cancer Center Utica, New York  13502
St. Joseph's Hospital Health Center - Syracuse Syracuse, New York  13203
Alexian Brothers Cancer Care Center Elk Grove Village, Illinois  60007
Arroyo Grande Community Hospital Arroyo Grande, California  93420
Lynn Regional Cancer Center of Boca Raton Community Hospital Boca Raton, Florida  33486
Hematology and Oncology of Northeast Georgia Athens, Georgia  30607
John B. Amos Community Cancer Center Columbus, Georgia  31902
Provena St. Mary's Wasser Regional Cancer Center - Kankakee Kankakee, Illinois  60901
St. Anthony's Cancer Center St. Louis, Missouri  63128
St. Elizabeth Boardman Cancer Center Boardman, Ohio  44512
St. Joseph Health Care Center Warren, Ohio  44484
St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown Youngstown, Ohio  44510
UW Health Oncology Madison, Wisconsin  53715
University of Wisconsin Cancer Center at Aspirus Wausau Hospital Wausau, Wisconsin  54401
Hematology Oncology Consultants Ltd. Naperville, Illinois  60540
United States Air Force Medical Center Wright-Patterson Wright-Patterson Afb, Ohio  45433-5529
Washington Hematology - Oncology Specialists Yakima, Washington  98902
North Star Lodge Cancer Center Yakima, Washington  98902
Comprehensive Cancer Center at Gaston Memorial Gastonia, North Carolina  28053-1747
Kent General Hospital at Bayhealth Medical Center Dover, Delaware  19901
Augusta Oncology Associates Augusta, Georgia  30901
Toledo Clinic Oregon, Ohio  43616
Baptist Hospital of East Tennessee Knoxville, Tennessee  37920
Hematology & Oncology Clinic Hattiesburg, Mississippi  39402
Cancer Center at Ottumwa Regional Health Center Ottumwa, Iowa  52501
Shands Cancer Center at the University of Florida - Jacksonville Gainesville, Florida  32610
Holy Family Memorial Medical Center Manitowoc, Wisconsin  54221
Cancer Center at Stormont-Vail Regional Health Center Topeka, Kansas  66604
Arlington Cancer Center - Arlington Arlington, Texas  76012
Mount Carmel Regional Cancer Center Pittsburg, Kansas  66762
Union State Bank Cancer Center at Nyack Hospital Nyack, New York  10960-1998
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center Dubois, Pennsylvania  15801
Florida Hospital - Orlando Orlando, Florida  32803
Medical Consultants Milwaukee, Wisconsin  53215-3690
Norwalk Hospital Norwalk, Connecticut  06856
Cancer Center of Colorado Springs Colorado Springs, Colorado  80907
Medical and Surgical Specialists, LLC Galesburg, Illinois  61401
Commonwealth Hematology-Oncology P.C. - Quincy Quincy, Massachusetts  02169
St. Luke's-Roosevelt Hospital Center - St.Luke's Division New York, New York  10025
Kenton Oncology, Inc. Kenton, Ohio  43326
Jones Clinic Germantown, Tennessee  38138
Vince Lombardi Cancer Center - Elkhorn Elkhorn, Wisconsin  53121
Oncology Alliance, S.C. - Milwaukee - East Glendale, Wisconsin  53212
Froedtert Hospital and Medical College of Wisconcin Milwaukee, Wisconsin  53226-3596