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Analysis of Brain Metastasis in Patients With Lung Cancer

Not Enrolling
Carcinoma, Non-Small -Cell Lung

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Trial Information

Analysis of Brain Metastasis in Patients With Lung Cancer

Introduction: The molecular and genetic events that permit tumor metastasis are not well
understood. The process whereby tumor cells escape the primary, local tumor, spread to
distant sites in the body and find and create conditions conducive to growth in these
disparate tissues remains an area of intense investigation. Metastasis of epithelial
tumors, such as lung cancer, to the brain is a common problem, with significant consequences
with respect to neurological dysfunction and shortening of survival.

Objective: To study two subset of patients with non small cell lung cancer (NSCLC)
metastatic to the brain, to identify genes and proteins that facilitate metastasis.

Study Population: 78 patients with NSCLC (n=39 squamous cell (SQ), and n=39 adenocarcinoma
(AC) tumors) metastatic to the brain to compare with published microarray studies of
non-metastatic NSCLC patients with these tumor types as well as with one another to help
explain the differential trend toward metastasis in some patients with NSCLC and not others,
as well as the differential trend to brain metastasis in the AC subtype.

Anticipated Risks and Benefits: Less than minimal risk to the patients to sample tissue
already removed from the brain as part of medically-necessary surgery and to sample blood.
No direct benefit to the patient is expected.

Outcome Estimate and Potential Meaning for the Field: That this very detailed investigation
of the genes and proteins expressed differentially between the non-metastatic and metastatic
NSCLCs, as well as between SQ and AC subtypes will identify new or previously-unsuspected
targets for new therapies to either prevent the development of brain metastasis or to treat
brain metastases more effectively.

Inclusion Criteria:

1. A patient with a known or with radiographic evidence of a NSCLC neoplasm metastatic
to the brain, either SQ or AC.

2. Medically-indicated (diagnostic and/or therapeutic) brain tumor resection.

3. Informed consent from female patient, age 18 or older. In general, patients less
than 18 years of age rarely have NSCLC metastatic to the brain.

Exclusion Criteria:

1. Inability to provide informed consent prior to surgery.

2. Medical conditions that cannot be corrected prior to surgery that would be standard
contraindications for craniotomy (brain tumor patients).

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

October 2003

Completion Date:

October 2004

Related Keywords:

  • Carcinoma, Non-Small -Cell Lung
  • Microarray
  • Genomics
  • Trastuzumab
  • Carcinoma
  • Non-Small Cell Lung Cancer
  • Metastatic Brain Tumor
  • Brain
  • Microarrays
  • Microdissection
  • Lung Cancer
  • Carcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Neoplasm Metastasis



National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland  20892