Phase III Trial of Continuous Schedule AC + G vs. Q 2 Week Schedule AC, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy in Node-Positive or High-Risk Node-Negative Breast Cancer
Phase 3
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Both
Breast Cancer
Both
Breast Cancer
Trial Information
Phase III Trial of Continuous Schedule AC + G vs. Q 2 Week Schedule AC, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy in Node-Positive or High-Risk Node-Negative Breast Cancer
OBJECTIVES:
- Compare the disease-free survival of patients with node-positive or high-risk
node-negative breast cancer treated with 2 different schedules of adjuvant doxorubicin,
cyclophosphamide, and paclitaxel.
- Compare the overall survival of patients treated with these regimens.
- Compare the toxic effects of these regimens in these patients.
- Correlate outcome with putative prognostic markers in patients treated with these
regimens.
OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 2
treatment arms (arms V and VI) (arms I-IV closed 11/10/10).
- Arm I: (closed 11/10/10) Patients receive doxorubicin IV and cyclophosphamide IV on day
1 and pegfilgrastim subcutaneously (SC) on day 2 or filgrastim (G-CSF) SC on days 3-10.
Treatment repeats every 14 days for 6 courses.
Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive
paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every
14 days for 6 courses.
- Arm II: (closed 11/10/10) Patients receive doxorubicin IV on day 1, oral
cyclophosphamide on days 1-7, and G-CSF SC on days 2-7. Treatment repeats every 7 days
for 15 courses.
Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel and
pegfilgrastim as in arm I.
- Arm III: (closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and
pegfilgrastim or G-CSF as in arm I.
Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive
paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses.
- Arm IV: (closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and G-CSF as
in arm II.
Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel as in
arm III.
- Arm V: Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and
pegfilgrastim SC on day 2. Treatment repeats every 14 days for 4 courses. Patients
receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2.
Treatment repeats every 14 days for 6 courses.
Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive
paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every
14 days for 6 courses.
- Arm VI: Patients receive doxorubicin, cyclophosphamide, and pegfilgrastim as in arm V.
Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive
paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses.
In all arms, treatment continues in the absence of disease progression or unacceptable
toxicity.
In all arms patients with HER2/neu-positive tumors also receive trastuzumab (Herceptin®)
weekly or every 3 weeks beginning concurrently with paclitaxel OR 3 months after the last
dose of paclitaxel and continuing for up to 52 weeks.
In all arms, patients with estrogen-receptor or progesterone-receptor positive tumors
receive hormonal therapy beginning within 28 days of the completion of adjuvant chemotherapy
or radiotherapy (if given).
After finishing study treatment patients are followed up every 6 months for 5 years and then
once a year for up to 15 years.
PROJECTED ACCRUAL: A total of 3,250 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed stage I-III invasive breast cancer
- Operable disease
- Stage I, II, IIIA, and IIIC (T1-3, N3a only)
- No T4 tumors
- High-risk disease, defined by 1 of the following:
- Tumor ≥ 2 cm in greatest diameter (includes both invasive and intraductal
component)
- Patients with nodal status of N0+ (i.e., no cluster of tumor cells in any
node greater than 0.2 mm) are considered to be node negative and must have
a primary tumor ≥ 2 cm in size or have a tumor ≥ 1 cm with high risk
features
- Patients who are node negative on the basis of a sentinel node procedure
and fewer than 6 axillary nodes are removed are eligible OR at least 6
axillary or intramammary nodes must be negative
- Tumor ≥ 1 cm in diameter and meeting 1 of the following criteria:
- ER-negative and PgR-negative
- ER-positive or PgR-positive with a Genomic Health Recurrence Score of ≥ 26
- One or more axillary or intramammary nodes are involved by metastatic breast
cancer
- If one or more nodes is involved, a minimum of 6 axillary or intramammary
nodes must have been examined histologically
- Patients with N0(I+) disease will be considered node negative
- HER2/neu-positive tumors (3+ by immunohistochemical staining or amplified by
fluorescence in-situ hybridization) allowed
- Bilateral synchronous breast cancer diagnosed within 1 month of each other allowed
provided the higher TNM stage primary tumor meets the eligibility criteria
- Prior modified radical mastectomy OR local excision of all tumors with axillary lymph
node dissection or sentinel node resection required
- No more than 84 days since prior surgery for the primary tumor and/or axilla
- Final resection margins for the primary tumor must be histologically negative
for invasive cancer and ductal carcinoma in situ
- Resection margins positive for lobular carcinoma in situ are allowed
- Hormone receptor status:
- Estrogen receptor status known
- Progesterone receptor status known
PATIENT CHARACTERISTICS:
Age
- 18 and over
Sex
- Male or female
Menopausal status
- Not specified
Performance status
- Zubrod 0-2
Life expectancy
- Not specified
Hematopoietic
- Absolute neutrophil count at least 1,200/mm^3
- Platelet count at least 100,000/mm^3
Hepatic
- Bilirubin no greater than upper limit of normal (ULN)
- Alkaline phosphatase no greater than 2 times ULN
- SGOT or SGPT no greater than 2 times ULN
Renal
- Creatinine no greater than ULN
Cardiovascular
- No congestive heart failure
- No active angina pectoris
- LVEF greater than or equal to the lower limit of normal* by MUGA or echocardiogram
NOTE: Patients age 60 and over OR with a history of hypertension
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, in situ cervical carcinoma, or lobular carcinoma in situ
of the breast
- Prior invasive breast cancer or ductal carcinoma in situ allowed if disease-free
for 5 years
- HIV negative
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- No prior cytotoxic chemotherapy for this breast cancer
- No prior chemotherapy with an anthracycline, anthracenedione, or taxane
Endocrine therapy
- Not specified
Radiotherapy
- No prior radiotherapy for this malignancy
- At least 2 weeks since prior radiotherapy for ductal carcinoma in situ
Surgery
- See Disease Characteristics
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Disease-free survival by medical history, physical exam, and mammograms every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
Outcome Time Frame:
every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
Safety Issue:
No
Principal Investigator
George Thomas Budd, MD
Investigator Role:
Study Chair
Investigator Affiliation:
The Cleveland Clinic
Authority:
United States: Federal Government
Study ID:
CDR0000334899
NCT ID:
NCT00070564
Start Date:
November 2003
Completion Date:
February 2017
Related Keywords:
- Breast Cancer
- stage II breast cancer
- stage IA breast cancer
- stage IB breast cancer
- stage IIIC breast cancer
- male breast cancer
- HER2-positive breast cancer
- estrogen receptor-negative breast cancer
- estrogen receptor-positive breast cancer
- progesterone receptor-negative breast cancer
- progesterone receptor-positive breast cancer
- Breast Neoplasms
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
| Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
| Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
| Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois 60153-5500 |
| Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
| Cleveland Clinic Cancer Center | Cleveland, Ohio 44195 |
| Tripler Army Medical Center | Honolulu, Hawaii 96859-5000 |
| CCOP - Wichita | Wichita, Kansas 67214-3882 |
| Hurley Medical Center | Flint, Michigan 48503 |
| University of Texas Health Science Center at San Antonio | San Antonio, Texas 78284-7811 |
| CCOP - Atlanta Regional | Atlanta, Georgia 30342-1701 |
| CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
| CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
| CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
| CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
| CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
| CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
| CCOP - Northern New Jersey | Hackensack, New Jersey 07601 |
| Rush-Copley Cancer Care Center | Aurora, Illinois 60507 |
| Joliet Oncology-Hematology Associates, Limited - West | Joliet, Illinois 60435 |
| Saint Anthony Memorial Health Centers | Michigan City, Indiana 46360 |
| Cedar Rapids Oncology Associates | Cedar Rapids, Iowa 52403 |
| Mercy Medical Center - Sioux City | Sioux City, Iowa 51104 |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa 51101 |
| St. Luke's Regional Medical Center | Sioux City, Iowa 51104 |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
| Saint Joseph Mercy Cancer Center | Ann Arbor, Michigan 48106-0995 |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn, Michigan 48123-2500 |
| Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
| Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
| West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
| Borgess Medical Center | Kalamazooaa, Michigan 49001 |
| Sparrow Regional Cancer Center | Lansing, Michigan 48912-1811 |
| St. John Macomb Hospital | Warren, Michigan 48093 |
| Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
| Fairview Southdale Hospital | Edina, Minnesota 55435 |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
| Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
| Minnesota Oncology Hematology, PA - Maplewood | Maplewood, Minnesota 55109 |
| HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota 55109 |
| Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota 55415 |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota 55407 |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota 55379 |
| Park Nicollet Cancer Center | St. Louis Park, Minnesota 55416 |
| Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
| United Hospital | St. Paul, Minnesota 55102 |
| Ridgeview Medical Center | Waconia, Minnesota 55387 |
| Minnesota Oncology Hematology, PA - Woodbury | Woodbury, Minnesota 55125 |
| Mercy Cancer Center at Mercy Medical Center | Canton, Ohio 44708 |
| Case Comprehensive Cancer Center | Cleveland, Ohio 44106-5065 |
| St. Rita's Medical Center | Lima, Ohio 45801 |
| Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls, South Dakota 57117-5039 |
| Medical X-Ray Center, PC | Sioux Falls, South Dakota 57105 |
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | Madison, Wisconsin 53792-6164 |
| CCOP - Ochsner | New Orleans, Louisiana 70121 |
| Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
| CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
| Methodist Medical Center of Illinois | Peoria, Illinois 61636 |
| Memorial Hospital of South Bend | South Bend, Indiana 46601 |
| CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
| CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
| CCOP - Columbus | Columbus, Ohio 43206 |
| CCOP - Dayton | Kettering, Ohio 45429 |
| Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
| CCOP - Greenville | Greenville, South Carolina 29615 |
| University of Texas Medical Branch | Galveston, Texas 77555-1329 |
| LDS Hospital | Salt Lake City, Utah 84143 |
| Green Mountain Oncology Group | Rutland, Vermont 05701 |
| CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
| Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
| CCOP - Grand Rapids | Grand Rapids, Michigan 49503 |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
| CCOP - Columbia River Oncology Program | Portland, Oregon 97225 |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington 98405 |
| Cancer Research Center of Hawaii | Honolulu, Hawaii 96813 |
| Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles, California 90033-0804 |
| Veterans Affairs Medical Center - Denver | Denver, Colorado 80220 |
| Dwight David Eisenhower Army Medical Center | Fort Gordon, Georgia 30905-5650 |
| CCOP - St. Louis-Cape Girardeau | Saint Louis, Missouri 63141 |
| Veterans Affairs Medical Center - San Antonio (Murphy) | San Antonio, Texas 78284 |
| CCOP - Northwest | Tacoma, Washington 98405-0986 |
| Sutter Cancer Center | Sacramento, California 95816 |
| Utah Valley Regional Medical Center - Provo | Provo, Utah 84604 |
| Peninsula Regional Medical Center | Salisbury, Maryland 21801 |
| MidMichigan Medical Center - Midland | Midland, Michigan 48670 |
| University of California Davis Cancer Center | Sacramento, California 95817 |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
| St. Vincent Mercy Medical Center | Toledo, Ohio 43608 |
| Arizona Cancer Center at University of Arizona Health Sciences Center | Tucson, Arizona 85724 |
| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock, Arkansas 72205 |
| Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | Kansas City, Kansas 66160-7353 |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington 98104 |
| Overlook Hospital | Summit, New Jersey 07902-0220 |
| Northside Hospital Cancer Center | Atlanta, Georgia 30342-1611 |
| Washington Cancer Institute at Washington Hospital Center | Washington, District of Columbia 20010 |
| Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
| St. John's Regional Health Center | Springfield, Missouri 65804 |
| UMDNJ University Hospital | Newark, New Jersey 07103 |
| McDowell Cancer Center at Akron General Medical Center | Akron, Ohio 44307 |
| CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
| Yale Cancer Center | New Haven, Connecticut 06520-8028 |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas 67214 |
| Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital | Baltimore, Maryland 21215 |
| Breslin Cancer Center at Ingham Regional Medical Center | Lansing, Michigan 48910 |
| Medical University of Ohio Cancer Center | Toledo, Ohio 43614 |
| Toledo Hospital | Toledo, Ohio 43606 |
| Providence Cancer Center at Sacred Heart Medical Center | Spokane, Washington 99220-2555 |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester, New York 14642 |
| McCreery Cancer Center at Ottumwa Regional | Ottumwa, Iowa 52501 |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
| Lewistown Hospital | Lewistown, Pennsylvania 17044 |
| Mount Nittany Medical Center | State College, Pennsylvania 16803 |
| Hematology Oncology Associates of the Quad Cities | Bettendorf, Iowa 52722 |
| Somerset Medical Center | Somerville, New Jersey 08876 |
| Batte Cancer Center at Northeast Medical Center | Concord, North Carolina 28025 |
| Parma Community General Hospital | Parma, Ohio 44129 |
| Saint Anthony's Hospital at Saint Anthony's Health Center | Alton, Illinois 62002 |
| Good Samaritan Regional Health Center | Mt. Vernon, Illinois 62864 |
| Battle Creek Health System Cancer Care Center | Battle Creek, Michigan 49017 |
| Northern Michigan Hospital | Petoskey, Michigan 49770 |
| William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan 48073 |
| Munson Medical Center | Traverse City, Michigan 49684 |
| David C. Pratt Cancer Center at St. John's Mercy | St. Louis, Missouri 63141 |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings, Montana 59101 |
| Big Sky Oncology | Great Falls, Montana 59405 |
| St. Peter's Hospital | Helena, Montana 59601 |
| Kalispell Regional Medical Center | Kalispell, Montana 59901 |
| Glacier Oncology, PLLC | Kalispell, Montana 59901 |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula, Montana 59802 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
| Adena Regional Medical Center | Chillicothe, Ohio 54601 |
| Doctors Hospital at Ohio Health | Columbus, Ohio 43228 |
| Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
| Grady Memorial Hospital | Delaware, Ohio 43015 |
| Fairfield Medical Center | Lancaster, Ohio 43130 |
| Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
| Community Hospital of Springfield and Clark County | Springfield, Ohio 45505 |
| Genesis - Good Samaritan Hospital | Zanesville, Ohio 43701 |
| American Fork Hospital | American Fork, Utah 84003 |
| Logan Regional Hospital | Logan, Utah 84321 |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City, Utah 84106 |
| Olympic Hematology and Oncology | Bremerton, Washington 98310 |
| Skagit Valley Hospital Cancer Care Center | Mt. Vernon, Washington 98273 |
| University Cancer Center at University of Washington Medical Center | Seattle, Washington 98195 |
| Harborview Medical Center | Seattle, Washington 98104 |
| Group Health Central Hospital | Seattle, Washington 98104 |
| North Puget Oncology at United General Hospital | Sedro-Wooley, Washington 98284 |
| Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
| New York Weill Cornell Cancer Center at Cornell University | New York, New York 10021 |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco, California 94115 |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise, Idaho 83712-6297 |
| Swedish-American Regional Cancer Center | Rockford, Illinois 61104-2315 |
| Tulane Cancer Center Office of Clinical Research | Alexandria, Louisiana 71315-3198 |
| Butterworth Hospital at Spectrum Health | Grand Rapids, Michigan 49503-2560 |
| Keesler Air Force Base Medical Center | Keesler AFB, Mississippi 39534-2511 |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
| CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
| St. Barnabas Medical Center Cancer Center | Livingston, New Jersey 07039 |
| University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
| Beth Israel Medical Center - Petrie Division | New York, New York 10003-3803 |
| St. Luke's - Roosevelt Hospital Center - St.Luke's Division | New York, New York 10027 |
| Knight Cancer Institute at Oregon Health and Science University | Portland, Oregon 97239-3098 |
| Madigan Army Medical Center - Tacoma | Tacoma, Washington 98431 |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin 54601 |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
| Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois 62526 |
| Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach, California 90801 |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
| Elkhart General Hospital | Elkhart, Indiana 46515 |
| Howard Community Hospital | Kokomo, Indiana 46904 |
| Lakeland Regional Cancer Care Center - St. Joseph | St. Joseph, Michigan 49085 |
| Hope A Women's Cancer Center | Asheville, North Carolina 28801 |
| Cleveland Clinic Cancer Center at Fairview Hospital | Cleveland, Ohio 44111 |
| Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
| Hillcrest Cancer Center at Hillcrest Hospital | Mayfield Heights, Ohio 44124 |
| Fox Chase Cancer Center - Philadelphia | Philadelphia, Pennsylvania 19111-2497 |
| Hematology Oncology Associates - Skokie | Skokie, Illinois 60076 |
| University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
| Fox Valley Hematology and Oncology - East Grant Street | Appleton, Wisconsin 54911-3496 |
| All Saints Cancer Center at Wheaton Franciscan Healthcare | Racine, Wisconsin 53405 |
| Peninsula Medical Center | Burlingame, California 94010 |
| Sutter Health - Western Division Cancer Research Group | Greenbrae, California 94904 |
| Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
| Sutter Cancer Center at Roseville Medical Center | Roseville, California 95661 |
| California Pacific Medical Center - California Campus | San Francisco, California 94118 |
| Sutter Solano Medical Center | Vallejo, California 94589 |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter, Florida 33458 |
| Saint Joseph's Hospital of Atlanta | Atlanta, Georgia 30342-1701 |
| Piedmont Hospital | Atlanta, Georgia 30309 |
| WellStar Cobb Hospital | Austell, Georgia 30106 |
| Charles B. Eberhart Cancer Center at DeKalb Medical Center | Decatur, Georgia 30033 |
| Gwinnett Medical Center | Lawrenceville, Georgia 30045 |
| Kennestone Cancer Center at Wellstar Kennestone Hospital | Marietta, Georgia 30060 |
| Southern Regional Medical Center | Riverdale, Georgia 30274-2600 |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise, Idaho 83706 |
| St. Joseph Medical Center | Bloomington, Illinois 61701 |
| Graham Hospital | Canton, Illinois 61520 |
| Memorial Hospital | Carthage, Illinois 62321 |
| Hematology and Oncology Associates | Chicago, Illinois 60611 |
| Eureka Community Hospital | Eureka, Illinois 61530 |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey, Illinois 60426 |
| Mason District Hospital | Havana, Illinois 62644 |
| North Shore Oncology and Hematology Associates, Limited - Libertyville | Libertyville, Illinois 60048 |
| McDonough District Hospital | Macomb, Illinois 61455 |
| Edward Hospital Cancer Center | Naperville, Illinois 60540 |
| Hematology Oncology Consultants - Naperville | Naperville, Illinois 60540 |
| BroMenn Regional Medical Center | Normal, Illinois 61761 |
| Community Cancer Center | Normal, Illinois 61761 |
| Community Hospital of Ottawa | Ottawa, Illinois 61350 |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois 61350 |
| Cancer Treatment Center at Pekin Hospital | Pekin, Illinois 61554 |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois 61615 |
| OSF St. Francis Medical Center | Peoria, Illinois 61637 |
| Proctor Hospital | Peoria, Illinois 61614 |
| Illinois Valley Community Hospital | Peru, Illinois 61354 |
| Perry Memorial Hospital | Princeton, Illinois 61356 |
| St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana 46107 |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne, Indiana 46815 |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
| Genesis Regional Cancer Center at Genesis Medical Center | Davenport, Iowa 52803 |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines, Iowa 50309 |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines, Iowa 50314 |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
| Medical Oncology and Hematology Associates - West Des Moines | West Des Moines, Iowa 50266 |
| Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas 67801 |
| St. Francis Comprehensive Cancer Center | Topeka, Kansas 66606 |
| Louisiana State University Health Sciences Center - Monroe | Monroe, Louisiana 71210 |
| Feist-Weiller Cancer Center at Louisiana State University Health Sciences | Shreveport, Louisiana 71130-3932 |
| Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan 49221 |
| Bay Regional Medical Center | Bay City, Michigan 48708 |
| Mecosta County Medical Center | Big Rapids, Michigan 49307 |
| Community Cancer Center of Monroe | Monroe, Michigan 48162 |
| Providence Cancer Institute at Providence Hospital - Southfield Campus | Southfield, Michigan 48075 |
| Alexandria, Minnesota 56308 | |
| Coborn Cancer Center | Saint Cloud, Minnesota 56303 |
| CentraCare Clinic - River Campus | St. Cloud, Minnesota 56303 |
| Saint Francis Medical Center | Cape Girardeau, Missouri 63701 |
| Immanuel Medical Center | Omaha, Nebraska 68122 |
| Creighton University Medical Center | Omaha, Nebraska 68131-2197 |
| Highland Hospital of Rochester | Rochester, New York 14620 |
| Bismarck Cancer Center | Bismarck, North Dakota 58501 |
| Wood County Oncology Center | Bowling Green, Ohio 43402 |
| Samaritan North Cancer Care Center | Dayton, Ohio 45415 |
| Grandview Hospital | Dayton, Ohio 45405 |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
| Good Samaritan Hospital | Dayton, Ohio 45406 |
| Blanchard Valley Medical Associates | Findlay, Ohio 45840 |
| Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
| Lima Memorial Hospital | Lima, Ohio 45804 |
| Northwest Ohio Oncology Center | Maumee, Ohio 43537 |
| Middletown Regional Hospital | Middletown, Ohio 45044 |
| Toledo Clinic - Oregon | Oregon, Ohio 43616 |
| St. Charles Mercy Hospital | Oregon, Ohio 43616 |
| North Coast Cancer Care, Incorporated | Sandusky, Ohio 44870 |
| Mercy Hospital of Tiffin | Tiffin, Ohio 44883 |
| Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio 43623 |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio 45373-1300 |
| Fulton County Health Center | Wauseon, Ohio 43567 |
| Cleveland Clinic - Wooster | Wooster, Ohio 44691 |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio 45385 |
| Providence Milwaukie Hospital | Milwaukie, Oregon 97222 |
| Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon 97213-2967 |
| Providence St. Vincent Medical Center | Portland, Oregon 97225 |
| UMC Southwest Cancer and Research Center | Lubbock, Texas 79415-3364 |
| University Hospital - San Antonio | San Antonio, Texas 78229 |
| Dixie Regional Medical Center - East Campus | Saint George, Utah 84770 |
| Minor and James Medical, PLLC | Seattle, Washington 98104 |
| Southwest Washington Medical Center Cancer Center | Vancouver, Washington 98668 |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima, Washington 98902 |
| Holy Family Memorial Medical Center Cancer Care Center | Manitowoc, Wisconsin 54221-1450 |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan, Wyoming 82801 |
| Denver Health Medical Center | Denver, Colorado 80204-4507 |
| Montrose Memorial Hospital Cancer Center | Montrose, Colorado 81401 |
| St. Francis Hospital | Federal Way, Washington 98003 |
| St. Clare Hospital | Lakewood, Washington 98499-0998 |
| Providence St. Peter Hospital Regional Cancer Center | Olympia, Washington 98506 |
| Good Samaritan Cancer Center | Puyallup, Washington 98371 |
| Allenmore Hospital | Tacoma, Washington 98411-0414 |
| Pottstown Memorial Regional Cancer Center | Pottstown, Pennsylvania 19464 |
| Hembree Mercy Cancer Center at St. Edward Mercy Medical Center | Ft. Smith, Arkansas 72903 |
| California Cancer Center - Woodward Park Office | Fresno, California 93720 |
| Highland General Hospital | Oakland, California 94602 |
| Pearlman Comprehensive Cancer Center at South Georgia Medical Center | Valdosta, Georgia 31603 |
| Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City, Iowa 50401 |
| Regional Cancer Center at Singing River Hospital | Pascagoula, Mississippi 39581 |
| Missouri Baptist Cancer Center | St. Louis, Missouri 63131 |
| Cancer Resource Center - Lincoln | Lincoln, Nebraska 68510 |
| Altru Cancer Center at Altru Hospital | Grand Forks, North Dakota 58201 |
| UAB Comprehensive Cancer Center | Birmingham, Alabama 35294 |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley, California 94704 |
| Herbert D. Kerman Regional Oncology Center - Daytona Beach | Daytona Beach, Florida 32114 |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
| John B. Amos Cancer Center | Columbus, Georgia 31904 |
| Harbin Clinic Cancer Center - Medical Oncology | Rome, Georgia 30165 |
| Saint Joseph Hospital | Chicago, Illinois 60657 |
| Kellogg Cancer Care Center | Highland Park, Illinois 60035 |
| Cancer Care and Hematology Specialists of Chicagoland - Niles | Niles, Illinois 60714 |
| Michiana Hematology-Oncology, PC - Elkhart | Elkhart, Indiana 46514 |
| Elkhart Clinic, LLC | Elkhart, Indiana 46514-2098 |
| Michiana Hematology Oncology PC - La Porte | La Porte, Indiana 46350 |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka, Indiana 46545-1470 |
| Michiana Hematology Oncology PC - Plymouth | Plymouth, Indiana 46563 |
| Reid Hospital & Health Care Services | Richmond, Indiana 47374 |
| McFarland Clinic, PC | Ames, Iowa 50010 |
| Cancer Center of Kansas, PA - Chanute | Chanute, Kansas 66720 |
| Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas 67042 |
| Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
| Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
| Cancer Center of Kansas, PA - Kingman | Kingman, Kansas 67068 |
| Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
| Cancer Center of Kansas, PA - Liberal | Liberal, Kansas 67905 |
| Cancer Center of Kansas, PA - Newton | Newton, Kansas 67114 |
| Menorah Medical Center | Overland Park, Kansas 66209 |
| Saint Luke's Hospital - South | Overland Park, Kansas 66213 |
| Cancer Center of Kansas, PA - Parsons | Parsons, Kansas 67357 |
| Cancer Center of Kansas, PA - Pratt | Pratt, Kansas 67124 |
| Cancer Center of Kansas, PA - Salina | Salina, Kansas 67401 |
| Cotton-O'Neil Cancer Center | Topeka, Kansas 66606 |
| Cancer Center of Kansas, PA - Wellington | Wellington, Kansas 67152 |
| Cancer Center of Kansas, PA - Wichita | Wichita, Kansas 67214 |
| Associates in Womens Health, PA - North Review | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Winfield | Winfield, Kansas 67156 |
| Ochsner Health Center - Bluebonnet | Baton Rouge, Louisiana 70809 |
| Foote Memorial Hospital | Jackson, Michigan 49201 |
| St. Mary Mercy Hospital | Livonia, Michigan 48154 |
| Mercy Memorial Hospital - Monroe | Monroe, Michigan 48162 |
| Michiana Hematology Oncology PC - Niles | Niles, Michigan 49120 |
| St. Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron, Michigan 48060 |
| Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw, Michigan 48601 |
| Lakeside Cancer Specialists, PLLC | Saint Joseph, Michigan 49085 |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota 56201 |
| Truman Medical Center - Hospital Hill | Kansas City, Missouri 64108 |
| St. Joseph Medical Center | Kansas City, Missouri 64114 |
| Heartland Hematology Oncology Associates, Incorporated | Kansas City, Missouri 64118 |
| North Kansas City Hospital | Kansas City, Missouri 64116 |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
| Research Medical Center | Kansas City, Missouri 64132 |
| Saint Luke's East - Lee's Summit | Lee's Summit, Missouri 64086 |
| Liberty Hospital | Liberty, Missouri 64068 |
| Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
| Saint Joseph Oncology, Incorporated | Saint Joseph, Missouri 64507 |
| Billings Clinic - Downtown | Billings, Montana 59107-7000 |
| Bozeman Deaconess Cancer Center | Bozeman, Montana 59715 |
| St. James Healthcare Cancer Care | Butte, Montana 59701 |
| Great Falls Clinic - Main Facility | Great Falls, Montana 59405 |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls, Montana 59405 |
| Northern Montana Hospital | Havre, Montana 59501 |
| Kalispell Medical Oncology at KRMC | Kalispell, Montana 59901 |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha, Nebraska 68124 |
| Summa Center for Cancer Care at Akron City Hospital | Akron, Ohio 44309-2090 |
| Barberton Citizens Hospital | Barberton, Ohio 44203 |
| Mary Rutan Hospital | Bellefontaine, Ohio 43311 |
| Grant Medical Center Cancer Care | Columbus, Ohio 43215 |
| Hematology Oncology Center | Elyria, Ohio 44035 |
| Community Cancer Center | Elyria, Ohio 44035 |
| Wayne Hospital | Greenville, Ohio 45331 |
| Knox Community Hospital | Mount Vernon, Ohio 43050 |
| Fisher-Titus Medical Center | Norwalk, Ohio 44857 |
| Flower Hospital Cancer Center | Sylvania, Ohio 43560 |
| St. Anne Mercy Hospital | Toledo, Ohio 43623 |
| Mount Carmel St. Ann's Cancer Center | Westerville, Ohio 43081 |
| Cleo Craig Cancer Research Clinic | Lawton, Oklahoma 73505 |
| Cancer Care Associates - Mercy Campus | Oklahoma City, Oklahoma 73120 |
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | Portland, Oregon 97210 |
| Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | Hershey, Pennsylvania 17033-0850 |
| Guthrie Cancer Center at Guthrie Clinic Sayre | Sayre, Pennsylvania 18840 |
| Hematology and Oncology Associates of Northeastern Pennsylvania | Scranton, Pennsylvania 18510 |
| Susquehanna Cancer Center at Divine Providence Hospital | Williamsport, Pennsylvania 17701 |
| Sandra L. Maxwell Cancer Center | Cedar City, Utah 84720 |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray, Utah 84157 |
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | Ogden, Utah 84403 |
| Fredericksburg Oncology, Incorporated | Fredericksburg, Virginia 22401 |
| St. Joseph Cancer Center | Bellingham, Washington 98225 |
| Providence Centralia Hospital | Centralia, Washington 98531-9027 |
| Columbia Basin Hematology | Kennewick, Washington 99336 |
| Harrison Poulsbo Hematology and Onocology | Poulsbo, Washington 98370 |
| Evergreen Hematology and Oncology, PS | Spokane, Washington 99218 |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington 98405-3004 |
| Wenatchee Valley Medical Center | Wenatchee, Washington 98801-2028 |
| Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital | Parkersburg, West Virginia 26102 |
| Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay, Wisconsin 54311 |
| UW Cancer Center Johnson Creek | Johnson Creek, Wisconsin 53038 |
| Vince Lombardi Cancer Clinic - Marinette | Marinette, Wisconsin 54143 |
| Vince Lombardi Cancer Clinic - Sheboygan | Sheboygan, Wisconsin 53081 |
| Aurora Medical Center | Summit, Wisconsin 53066 |
| Vince Lombardi Cancer Clinic - Two Rivers | Two Rivers, Wisconsin 54241 |
| Oncology Alliance, SC - Milwaukee - West | Wauwatosa, Wisconsin 53226 |
| Mid Dakota Clinic, PC | Bismarck, North Dakota 58501 |
| Regional Cancer Center at Memorial Medical Center | Springfield, Illinois 62781-0001 |
| St. Joseph Hospital Regional Cancer Center - Orange | Orange, California 92868-3849 |
| Queen's Cancer Institute at Queen's Medical Center | Honolulu, Hawaii 96813 |
| Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center | Englewood, New Jersey 07631 |
| Bethesda North Hospital | Cincinnati, Ohio 45242 |
| Kinston Medical Specialists | Kinston, North Carolina 28501 |
| Greenville Hospital Cancer Center | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Grove Commons | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Faris Road | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Greer Medical Oncology | Greer, South Carolina 29650 |
| Cancer Centers of the Carolinas - Seneca | Seneca, South Carolina 29672 |
| Cancer Centers of the Carolinas - Spartanburg | Spartanburg, South Carolina 29307 |
| MedCentral - Mansfield Hospital | Mansfield, Ohio 44903 |
| Resurrection Medical Center | Chicago, Illinois 60631 |
| Sherman Hospital | Elgin, Illinois 60120-2198 |
| St. Francis Hospital | Evanston, Illinois 60202 |
| Lapeer Regional Hospital | Lapeer, Michigan 48446 |
| St. John's Regional Medical Center | Joplin, Missouri 64804 |
| Freeman Cancer Institute at Freeman Health System | Joplin, Missouri 64803-2644 |
| McLeod Regional Medical Center | Florence, South Carolina 29501 |
| MBCCOP - Meharry Medical College - Nashville | Nashville, Tennessee 37208-3599 |
| Providence Cancer Center | Anchorage, Alaska 99508 |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids, Michigan 49503 |
| Metro Health Hospital | Grand Rapids, Michigan 49506 |
| PinnacleHealth Regional Cancer Center at Polyclinic Hospital | Harrisburg, Pennsylvania 17105 |
| University of Wisconcin Cancer Center at Aspirus Wausau Hospital | Wausau, Wisconsin 54401 |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland, New Jersey 08360 |
| Lipson Cancer and Blood Center at Rochester General Hospital | Rochester, New York 14621 |
| South Carolina Oncology Associates, PA | Columbia, South Carolina 29210 |
| Doctors Medical Center - San Pablo Campus | San Pablo, California 94806 |
| Galesburg Clinic, PC | Galesburg, Illinois 61401 |
| St. Vincent Healthcare Cancer Care Services | Billings, Montana 59101 |
| University of Tennessee Cancer Institute - Memphis | Memphis, Tennessee 38104 |
| Good Samaritan Hospital Cancer Treatment Center | Cincinnati, Ohio 45220 |
| Desert Regional Medical Center Comprehensive Cancer Center | Palm Springs, California 92262 |
| Parvin Radiation Oncology | Kansas City, Missouri 64116 |
| Midwest Hematology Oncology Group, Incorporated | Saint Louis, Missouri 63109 |
| Providence Cancer Center at Providence Hospital | Mobile, Alabama 36608 |
| East Bay Radiation Oncology Center | Castro Valley, California 94546 |
| Contra Costa Regional Medical Center | Martinez, California 94553-3156 |
| Tibotec Therapeutics - Division of Ortho Biotech Products, LP | Marysville, California 95901 |
| Memorial Medical Center | Modesto, California 95355 |
| El Camino Hospital Cancer Center | Mountain View, California 94040 |
| Larry G Strieff MD Medical Corporation | Oakland, California 94609 |
| Tom K Lee, Incorporated | Oakland, California 94609 |
| Bay Area Breast Surgeons, Incorporated | Oakland, California 94609 |
| Valley Medical Oncology Consultants - Pleasanton | Pleasanton, California 94588 |
| Kapiolani Medical Center at Pali Momi | Aiea, Hawaii 96701 |
| Kapiolani Medical Center for Women and Children | Honolulu, Hawaii 96826 |
| Straub Clinic and Hospital, Incorporated | Honolulu, Hawaii 96813 |
| Hawaii Medical Center - East | Honolulu, Hawaii 96817 |
| OnCare Hawaii, Incorporated - Kuakini | Honolulu, Hawaii 96817 |
| OnCare Hawaii, Incorporated - Lusitana | Honolulu, Hawaii 96813 |
| Maui Memorial Medical Center | Wailuku, Hawaii 96793 |
| Pacific Cancer Institute - Maui | Wailuku, Hawaii 96793 |
| Illinois CancerCare - Bloomington | Bloomington%, Illinois 61701 |
| Illinois CancerCare - Canton | Canton, Illinois 61520 |
| Illinois CancerCare - Carthage | Carthage, Illinois 62321 |
| Elmhurst Memorial Hospital | Elmhurst, Illinois 60126 |
| Illinois CancerCare - Eureka | Eureka, Illinois 61530 |
| Illinois CancerCare - Galesburg | Galesburg, Illinois 61401 |
| Illinois CancerCare - Havana | Havana, Illinois 62644 |
| Illinois CancerCare - Kewanee Clinic | Kewanee, Illinois 61443 |
| Illinois CancerCare - Macomb | Macomb, Illinois 61455 |
| OSF Holy Family Medical Center | Monmouth, Illinois 61462 |
| Illinois CancerCare - Monmouth | Monmouth, Illinois 61462 |
| Illinois CancerCare - Community Cancer Center | Normal, Illinois 61761 |
| Illinois CancerCare - Pekin | Pekin, Illinois 61603 |
| Illinois CancerCare - Peru | Peru, Illinois 61354 |
| Illinois CancerCare - Princeton | Princeton, Illinois 61356 |
| Illinois CancerCare - Spring Valley | Spring Valley, Illinois 61362 |
| Caritas St. Elizabeth's Medical Center | Brighton, Massachusetts 02135-2997 |
| Mercy General Health Partners | Muskegon, Michigan 49443 |
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord, New Hampshire 03301 |
| New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett, New Hampshire 03106 |
| Bay Area Hospital | Coos Bay, Oregon 97420 |
| Franciscan Skemp Healthcare - La Crosse Campus | La Crosse, Wisconsin 54601 |
| Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg, Pennsylvania 18301 |
| Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center | Upland, Pennsylvania 19013 |
| Medcenter One Hospital Cancer Care Center | Bismarck, North Dakota 58501 |
| St. Alexius Medical Center Cancer Center | Bismarck, North Dakota 58502 |
| Hematology-Oncology Associates of Fredericksburg, Incorporated | Fredericksburg, Virginia 22401 |
| University of Colorado Cancer Center at UC Health Sciences Center | Aurora, Colorado 80045 |
| Christus Schumpert Cancer Treatment Center | Shreveport, Louisiana 71101 |
| Hematology Oncology Associates, PC | Albuquerque, New Mexico 87106 |
| Regional Medical Center | Anniston, Alabama 36202 |
| Valley Medical Oncology Consultants - Castro Valley | Castro Valley, California 94546 |
| Valley Medical Oncology | Fremont, California 94538 |
| Memorial Hospital Cancer Center - Colorado Springs | Colorado Springs, Colorado 80909 |
| Provena St. Mary's Regional Cancer Center - Kankakee | Kankakee, Illinois 60901 |
| Heartland Oncology and Hematology | Council Bluffs, Iowa 51503 |
| Ochsner Health Center - Covington | Covington, Louisiana 70433 |
| Addison Gilbert Hospital | Gloucester, Massachusetts 01930 |
| New Orleans Cancer Institute at Memorial Medical Center | New Orleans, Louisiana 70115 |
| Cancer Centers of the Carolinas - Easley | Easley, South Carolina 29640 |
| Self Regional Cancer Center at Self Regional Medical Center | Greenwood, South Carolina 29646 |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota 55422-2900 |
| Lakeview Hospital | Stillwater, Minnesota 55082 |
| Princeton Community Hospital | Princeton, West Virginia 24740 |
| Mount Carmel Regional Cancer Center | Pittsburg, Kansas 66762 |
| Union State Bank Cancer Center at Nyack Hospital | Nyack, New York 10960-1998 |
| Northwest Cancer Specialists at Vancouver Cancer Center | Vancouver, Washington 98684 |
| CCOP - Kansas City | Prairie Village, Kansas 66208 |
| St. Agnes Hospital Cancer Center | Baltimore, Maryland 21229 |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh, Wisconsin 54904 |
| Shaw Regional Cancer Center | Edwards, Colorado 81632 |
| Kootenai Cancer Center - Coeur d'Alene | Coeur d'Alene, Idaho 83814 |
| Langlade Memorial Hospital | Antigo, Wisconsin 54409 |
| San Luis Valley Regional Medical Center | Alamosa, Colorado 81101 |
| Valley View Hospital Cancer Center | Glenwood Springs, Colorado 81601 |
| Florida Hospital Memorial Medical Center | Daytona Beach, Florida 32117 |
| Piedmont Fayette Hospital | Fayetteville, Georgia 30214 |
| Castle Medical Center | Kailua, Hawaii 96734 |
| Kauai Medical Clinic | Lihue, Hawaii 96766 |
| Central Dupage Cancer Center | Warrenville, Illinois 60555 |
| Hays Medical Center | Hays, Kansas 67601 |
| Hutchinson Hospital Corporation | Hutchinson, Kansas 67502 |
| Regional Cancer Center at Western Maryland Health System - Sacred Heart Campus | Cumberland, Maryland 21502 |
| Clemens Regional Medical Center | Mount Clemens, Michigan 48043 |
| Southeast Cancer Center | Cape Girardeau, Missouri 63703 |
| Goldschmidt Cancer Center | Jefferson City, Missouri 65109 |
| Comprehensive Cancer Care, PC | Saint Louis, Missouri 63141 |
| Lakeside Hospital | Omaha, Nebraska 68130 |
| Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital | Albuquerque, New Mexico 87110 |
| University of New Mexico Cancer Center - South | Las Cruces, New Mexico 88011 |
| Cleveland Clinic Beachwood Family Health and Surgery Center | Beachwood, Ohio 44122 |
| Cleveland Clinic Foundation - Strongsville | Strongsville, Ohio 44136 |
| Cancer Care Associates - Norman | Norman, Oklahoma 73071 |
| Cancer Care Associates at Troy and Dollie Smith Cancer Center | Oklahoma City, Oklahoma 73120 |
| Clackamas Radiation Oncology Center | Clackamas, Oregon 97015 |
| Providence Newberg Medical Center | Newberg, Oregon 97132 |
| Willamette Falls Hospital | Oregon City, Oregon 97045 |
| Butler Memorial Hospital | Butler, Pennsylvania 16001 |
| Texas Tech University Health Sciences Center School of Medicine - El Paso | El Paso, Texas 79905 |
| Island Hospital Cancer Care Center at Island Hospital | Anacortes, Washington 98221 |
| Highline Medical Center Cancer Center | Burien, Washington 98166 |
| Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids, Wisconsin 54494 |
