Know Cancer

forgot password

Spectroscopic Determination of Brain Tumor Cells

Not Enrolling
Epilepsy, Temporal Lobe, Temporal Lobe

Thank you

Trial Information

Spectroscopic Determination of Brain Tumor Cells

Optical spectroscopy for detection of brain tumors and tumor margins has been shown to be of
use in distinguishing gliomas and metastatic tumor cells from surrounding white matter.
Optical spectroscopy has the potential to provide immediate and accurate diagnostic
information about the nature and quantity of neoplastic cells, in a minimally-or
non-invasive fashion. We propose to use a new method of optical spectroscopy, polarized
light-scattering spectroscopy (LSS), which permits discrimination of malignant cancer cells
from normal brain cells by virtue of alterations in the cytoplasmic and nuclear ratios of
these cells.

Patients suspected of having, or with prior biopsy proof of, a WHO grade II-IV central
nervous system (CNS) glial tumor(s); those with metastatic brain tumor; or patients with
medically-refractory temporal lobe epilepsy with a presumed hippocampal source of seizures,
who are seen in the Surgical Neurology Branch, NINDS, will be considered for entry into this
study. Tissue samples of tumor or normal lateral temporal neocortex resected as part of
standard care will be collected at surgery and utilized for research.

Inclusion Criteria


1. Radiographic evidence of primary glial neoplasm of the CNS (WHO grade II-IV) or any
patient with a known primary neoplasm of the CNS; patients with a known or with
radiographic evidence of resectable metastatic brain tumor(s); or patients with
temporal lobe epilepsy (TLE) in whom resective surgery, which will include the
lateral termporal neocortex, is indicated.

2. Informed consent from patients age 18 or older.

3. No racial or ethnic group or gender is excluded.

4. Pregnant women who require brain surgery may participate in this study.


1. Inability to provide informed consent prior to surgery.

2. Medical conditions that cannot be corrected prior to surgery that would be standard
contraindications for neurosurgery.

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

August 2003

Completion Date:

October 2004

Related Keywords:

  • Epilepsy, Temporal Lobe
  • Temporal Lobe
  • Glioma
  • Brain Tumor
  • Spectroscopy
  • Brain Neoplasms
  • Epilepsy
  • Epilepsy, Temporal Lobe



National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland  20892