A Phase II Trial of Induction Chemoradiotherapy With Cisplatin/Etoposide Followed by Surgical Resection, Followed by Docetaxel, for Non-Small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors)

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed non-small cell lung cancer

- Any of the following stages due to involvement of the superior sulcus:

- Stage IIB (T3, N0), IIIA (T3, N1), or IIIB (T4, N0-1)

- Newly diagnosed

- Primary bronchogenic

- Must meet 1 of the following tumor involvement criteria:

- An apical tumor associated with the Pancoast syndrome (arm or shoulder pain
and/or neurologic findings corresponding to the roots of C-8 and/or T-1 or the
inferior trunk of the bronchial plexus with or without Horner's syndrome)
without rib or vertebral body involvement

- Superior sulcus tumors with involvement of the chest wall (T3), usually ribs 1
and 2 by CT scan or MRI, with or without an associated Pancoast syndrome

- Superior sulcus tumors with invasion of the vertebral bodies or involvement of
the subclavian vessels (T4) by CT scan or MRI, with or without an associated
Pancoast syndrome

- No more than 1 parenchymal lesion in the same lung or in both lungs

- No involvement of the following lymph node groups as determined by mediastinal
exploration* (i.e., mediastinoscopy, mediastinotomy, thoracoscopy, or thoracotomy)
within the past 42 days:

- Single-level or multi-level ipsilateral or contralateral mediastinal nodal (N2
or N3) disease by mediastinoscopy, thoracoscopy, mediastinotomy, thoracotomy, or
transbronchial Wang needle biopsy, regardless of whether enlarged nodes are
visible or not on chest x-ray or CT scan

- Supraclavicular (scalene) nodes

- Any nodes evident on physical exam must be biopsied by fine needle
aspiration or open biopsy

- Left upper lobe tumors with left vocal cord paralysis by indirect laryngoscopy
(presumes N2 nodes in the A-P window) NOTE: *Mediastinal exploration is not
required for patients whose mediastinum is negative by both positron-emission
tomography (PET) and CT scan

- No pleural effusions except if 1 of the following criteria are met:

- Pleural effusion present before mediastinoscopy or thoracotomy with negative
cytology on 2 separate thoracenteses

- Pleural effusion present only after exploratory or staging thoracotomy, with
negative cytology on a single thoracentesis

- Present only on CT scan and too small to tap

- No pericardial effusions or superior vena cava syndrome

- No brain metastases by CT scan or MRI

- No evidence of distant metastatic disease by bone scan or PET

- Must be a candidate for potential future pulmonary resection

PATIENT CHARACTERISTICS:

Age

- Not specified

Performance status

- Zubrod 0-2

- Patients with Zubrod performance status 2 must have an albumin level at least
0.85 times lower limit of normal and weight loss no greater than 10%

Life expectancy

- Not specified

Hematopoietic

- Absolute neutrophil count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

Hepatic

- Bilirubin no greater than 1.5 times upper limit of normal (ULN)*

- SGOT or SGPT no greater than 1.5 times ULN* NOTE: *Unless due to a documented benign
disease

Renal

- Creatinine clearance at least 50 mL/min

Cardiovascular

- No myocardial infarction within the past 3 months

- No active angina

- No unstable heart rhythms

- No clinically evident congestive heart failure

Pulmonary

- Preresection FEV_1 at least 2.0 L OR

- Predicted postresection FEV_1 greater than 1.0 L

Other

- Not pregnant or nursing

- Fertile patients must use effective contraception

- No uncontrolled peptic ulcer disease

- No grade 2 or greater sensory neuropathy

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy

- No concurrent colony-stimulating factors during chemoradiotherapy or course 1 of
consolidation therapy

Chemotherapy

- No prior chemotherapy for lung cancer

Endocrine therapy

- Not specified

Radiotherapy

- No prior radiotherapy to the neck or thorax

- No concurrent intensity-modulated radiotherapy

Surgery

- Prior exploratory thoracotomy allowed only for diagnosis or staging purposes

Other

- No concurrent amifostine