Inclusion Criteria:

- Patients must have disease that can be measured.

- Patients must meet criteria for either platinum-resistant or platinum-sensitive
ovarian or peritoneal cancer.

- Patients may only have had one prior platinum-based chemotherapy regimen.

- Patients must be willing and able to stop all aspirin and NSAID medications
immediately before and for a time after each treatment cycle (approx. 5-8 days)

- Patients must have normal kidney function.

Exclusion Criteria:

- Patients may not have a Low Malignant Potential or Borderline Ovarian Tumor.

- Patients may not have received pelvic or abdominal radiotherapy.

- Patients must not have evidence of or received treatment for another cancer within
the last 5 years.

- Patients must not have been diagnosed with a heart attack in the last 6 months.

- Patients who are unwilling or unable to take folic acid tablets, vitamin B12
injections or dexamethasone tablets.