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A Clinical Trial Comparing Anastrozole With Tamoxifen in Postmenopausal Patients With Ductal Carcinoma in Situ (DCIS) Undergoing Lumpectomy With Radiation Therapy

Phase 3
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

A Clinical Trial Comparing Anastrozole With Tamoxifen in Postmenopausal Patients With Ductal Carcinoma in Situ (DCIS) Undergoing Lumpectomy With Radiation Therapy


- Compare the value of anastrozole vs tamoxifen, in terms of preventing recurrence (i.e.,
local, regional, and distant recurrences and contralateral breast cancer), after
lumpectomy and radiotherapy in postmenopausal women with ductal carcinoma in situ

- Compare subsequent disease occurrence, in terms of invasive breast cancer (local,
regional, distant, or contralateral), ipsilateral and contralateral breast cancer
(invasive and DCIS), and non-breast second primary malignancies, in patients treated
with these drugs.

- Compare quality of life and symptoms of patients treated with these drugs.*

- Compare quality-adjusted survival time of patients treated with these drugs.*

- Compare the occurrence of osteoporotic fractures in patients treated with these drugs.

- Compare disease-free and overall survival of patients treated with these drugs. NOTE:
*The quality of life study closed to accrual as of 12/28/04.

OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients
are stratified according to age (under 60 vs 60 and over). Patients are randomized to 1 of 2
treatment arms (arm I and arm II closed to accrual as of 6/15/06).

- Arm I (closed to accrual as of 6/15/06): Patients receive oral tamoxifen and oral
placebo once daily for 5 years.

- Arm II (closed to accrual as of 6/15/06): Patients receive oral anastrozole and oral
placebo once daily for 5 years.

Beginning within 8 weeks of randomization, all patients also undergo whole breast
radiotherapy, unless the patient is enrolled in protocol NSABP-B-39 and randomized to the
partial breast irradiation group.

Patients are followed every 6 months for 5 years, and then annually thereafter.

For patients enrolled in the quality of life study, quality of life is assessed at baseline
and then every 6 months for 6 years.*

NOTE: *The quality of life study closed to accrual as of 12/28/04.

PROJECTED ACCRUAL: A total of 3,000 patients (1,500 per treatment arm) will be accrued for
this study within 5 years (arm I and arm II closed to accrual as of 6/15/06).

Inclusion Criteria


- Histologically confirmed ductal carcinoma in situ (DCIS) of the breast

- Mixed DCIS and lobular carcinoma in situ (LCIS) allowed

- Must have undergone lumpectomy

- Margins must be histologically free of disease

- Re-excision to obtain tumor-free margins allowed

- No more than 84 days since prior lumpectomy or re-excision

- More than 1 area of DCIS allowed provided all disease is removed with tumor-free

- Masses or clusters of calcification that are clinically or mammographically
suspicious must be biopsied

- No prior invasive breast cancer or DCIS

- Patients with a history of LCIS are eligible

- No prior or concurrent invasive (including microinvasive) breast cancer

- DCIS "suspicious" for microinvasion allowed

- No bilateral malignancy

- No mass or mammographic abnormality suspicious for malignancy in the opposite
breast unless not malignant as proven by biopsy

- No Paget's disease of the nipple

- No positive ipsilateral axillary or intramammary nodes

- No palpable nodes in the ipsilateral or contralateral axilla or palpable
supraclavicular or infraclavicular nodes unless not involved with tumor as
proven by biopsy

- Hormone receptor status:

- Estrogen- or progesterone-receptor positive as determined by

- Borderline results are considered positive



- See Menopausal status


- Female

Menopausal status:

- Postmenopausal as defined by at least 1 of the following:

- Prior documented bilateral oophorectomy

- At least 12 months without spontaneous bleeding

- Age 55 or over with prior hysterectomy without oophorectomy

- Age 54 or under with prior hysterectomy without oophorectomy with a documented
follicle-stimulating hormone level in the postmenopausal range

Performance status

- Zubrod 0-2

Life expectancy

- At least 10 years (excluding diagnosis of breast cancer)


- WBC normal


- AST normal

- Bilirubin normal

- Alkaline phosphatase normal

- No hepatic disease that would preclude administration of study drugs


- Creatinine normal

- No renal disease that would preclude administration of study drugs


- No prior documented cerebral vascular accident or transient ischemic attack

- No prior deep vein thrombosis

- No cardiovascular disease that would preclude administration of study drugs

- No uncontrolled hypertension (i.e., systolic blood pressure at least 180 mm Hg or
diastolic blood pressure at least 110 mm Hg based on the average of 2 or more
readings at each of 2 or more visits after initial screening)

- No uncontrolled atrial fibrillation


- No pulmonary embolus


- Not pregnant or nursing

- Patients with a history of non-breast malignancies are eligible provided they have
been disease-free for ≥ 5 years and are deemed by their physician to be at low risk
for recurrence

- No other malignancy within the past 5 years except treated basal cell or squamous
cell skin cancer, carcinoma in situ of the cervix, carcinoma in situ of the colon, or
melanoma in situ

- No psychiatric or addictive disorders that would preclude informed consent

- No uncontrolled diabetes, defined as hemoglobin A1C greater than 9% (fasting glucose
200 mg/dL)

- No nonmalignant systemic disease that would preclude administration of study drugs


Endocrine therapy

- No prior or concurrent aromatase inhibitors (e.g., exemestane or letrozole) or

- No concurrent raloxifene or other selective estrogen receptor modulators

- No concurrent sex hormone therapy (e.g., estrogen or progesterone replacement
therapy, oral contraceptives, androgens, luteinizing hormone releasing hormone
analogs, prolactin inhibitors, or antiandrogens)

- Low-dose estrogen vaginal creams or Estring allowed


- Radiotherapy for this cancer initiated before study is allowed


- See Disease Characteristics

- No prior or concurrent mastectomy for DCIS

- Prior sentinel node biopsy or axillary node dissection allowed provided nodes are
pathologically negative


- No concurrent warfarin

- No other systemic therapy for this cancer initiated before study

- No other concurrent anticancer therapy unless permitted by the protocol investigator

- No concurrent participation in another clinical trial of therapy for DCIS

- Concurrent participation in protocol NSABP-B-39 allowed

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Time to occurrence of first breast cancer event

Outcome Time Frame:

Every 6 months for 5 years then every 12 month thereafter

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

January 2003

Completion Date:

March 2016

Related Keywords:

  • Breast Cancer
  • breast cancer in situ
  • ductal breast carcinoma in situ
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
  • Carcinoma, Ductal



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Battle Creek Health System Cancer Care Center Battle Creek, Michigan  49017
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Northern Michigan Hospital Petoskey, Michigan  49770
William Beaumont Hospital - Royal Oak Campus Royal Oak, Michigan  48073
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Deaconess Billings Clinic - Downtown Billings, Montana  59101
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Sletten Regional Cancer Institute Great Falls, Montana  59405
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University Cancer Center at University of Washington Medical Center Seattle, Washington  98195
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Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital Greenville, North Carolina  27858-4354
Huntsman Cancer Institute at University of Utah Salt Lake City, Utah  84112
University of Virginia Cancer Center Charlottesville, Virginia  22908
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois  60611
Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois  62526
Lexington Clinic Cancer Center Lexington, Kentucky  40504
Paoli Memorial Hospital Paoli, Pennsylvania  19301-1792
Helen and Harry Gray Cancer Center at Hartford Hospital Hartford, Connecticut  06102-5037
Elkhart General Hospital Elkhart, Indiana  46515
Hope A Women's Cancer Center Asheville, North Carolina  28801
Cleveland Clinic Cancer Center at Fairview Hospital Cleveland, Ohio  44111
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights, Ohio  44124
Rosenfeld Cancer Center at Abington Memorial Hospital Abington, Pennsylvania  19001
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Allentown, Pennsylvania  18105
Baptist Centers for Cancer Care Memphis, Tennessee  38120
Front Range Cancer Specialists Fort Collins, Colorado  80528
Lakeland Regional Cancer Center at Lakeland Regional Medical Center Lakeland, Florida  33805
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Joan Karnell Cancer Center at Pennsylvania Hospital Philadelphia, Pennsylvania  19107
Jennersville Regional Hospital West Grove, Pennsylvania  19390-9499
Alta Bates Comprehensive Cancer Center Berkeley, California  94704
Peninsula Medical Center Burlingame, California  94010
Mount Diablo Regional Cancer Center Concord, California  94524-4110
North Bay Cancer Center Fairfield, California  94533
Kaiser Permanente - Fremont Fremont, California  94538
Sutter Health - Western Division Cancer Research Group Greenbrae, California  94904
Marin Cancer Institute at Marin General Hospital Greenbrae, California  94904
Saint Rose Hospital Hayward, California  94545
Kaiser Permanente Medical Center - Hayward Hayward, California  94545
Moores UCSD Cancer Center La Jolla, California  92093-0658
Memorial Medical Center Cancer Services Modesto, California  95355
Highland General Hospital at St. George's University School of Medicine Oakland, California  94602
Alta Bates Summit Medical Center - Summit Campus Oakland, California  94609
Valley Care Medical Center Pleasanton, California  94588
Kaiser Permanente Medical Center - Redwood City Redwood City, California  94063
Kaiser Permanente Medical Center - Richmond Richmond, California  94801
Kaiser Permanente Medical Center - Roseville Roseville, California  95661
Sutter Cancer Center at Roseville Medical Center Roseville, California  95661
South Sacramento Kaiser-Permanente Medical Center Sacramento, California  95823
Salinas Valley Memorial Hospital Salinas, California  93901
California Pacific Medical Center - California Campus San Francisco, California  94118
Kaiser Permanente Medical Center - Santa Teresa San Jose, California  95119
J.C. Robinson, M.D. Regional Cancer Center San Pablo, California  94806
Kaiser Foundation Hospital - San Rafael San Rafael, California  94903
Kaiser Permanente Medical Center - Santa Rosa Santa Rosa, California  95403
Kaiser Permanente Medical Center - South San Francisco South San Francisco, California  94080
Kaiser Permanente Medical Facility - Stockton Stockton, California  95210
Sutter Solano Medical Center Vallejo, California  94589
Kaiser Permanente Medical Center - Walnut Creek Walnut Creek, California  94596
John Muir/Mt. Diablo Comprehensive Cancer Center Walnut Creek, California  94598
Memorial Hospital Colorado Springs, Colorado  80909
Poudre Valley Hospital Fort Collins, Colorado  80524
St. Mary-Corwin Regional Medical Center Pueblo, Colorado  81004
Beebe Medical Center Lewes, Delaware  19958
St. Francis Hospital Wilmington, Delaware  19805
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Fort Lauderdale, Florida  33308
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Jupiter, Florida  33458
M.D. Anderson Cancer Center - Orlando Orlando, Florida  32806
Saint Joseph's Hospital of Atlanta Atlanta, Georgia  30342-1701
Piedmont Hospital Atlanta, Georgia  30309
WellStar Cobb Hospital Austell, Georgia  30106
Charles B. Eberhart Cancer Center at DeKalb Medical Center Decatur, Georgia  30033
Gwinnett Medical Center Lawrenceville, Georgia  30045
Kennestone Cancer Center at Wellstar Kennestone Hospital Marietta, Georgia  30060
Southern Regional Medical Center Riverdale, Georgia  30274-2600
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Boise, Idaho  83706
St. Joseph Medical Center Bloomington, Illinois  61701
Graham Hospital Canton, Illinois  61520
Memorial Hospital Carthage, Illinois  62321
Swedish Covenant Hospital Chicago, Illinois  60625
Mercy Hospital and Medical Center Chicago, Illinois  60616
Eureka Community Hospital Eureka, Illinois  61530
Galesburg Cottage Hospital Galesburg, Illinois  61401
Galesburg Clinic Galesburg, Illinois  61401
InterCommunity Cancer Center of Western Illinois Galesburg, Illinois  61401
Ingalls Cancer Care Center at Ingalls Memorial Hospital Harvey, Illinois  60426
Mason District Hospital Havana, Illinois  62644
Hopedale Medical Complex Hopedale, Illinois  61747
Kewanee Hospital Kewanee, Illinois  61443
McDonough District Hospital Macomb, Illinois  61455
Trinity Medical Center - East Moline, Illinois  61265
Edward Hospital Cancer Center Naperville, Illinois  60540
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - Peoria Peoria, Illinois  61615
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Perry Memorial Hospital Princeton, Illinois  61356
Hematology/Oncology of the North Shore at Gross Point Medical Center Skokie, Illinois  60076
St. Margaret's Hospital Spring Valley, Illinois  61362
Valley Cancer Center Spring Valley, Illinois  61362
St. Francis Hospital and Health Centers - Beech Grove Campus Beech Grove, Indiana  46107
Howard Community Hospital at Howard Regional Health System Kokomo, Indiana  46904
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
McFarland Clinic, P. C. Ames, Iowa  50010
St. Luke's Hospital Cedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Mercy Capitol Hospital Des Moines, Iowa  50307
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates - West Des Moines West Des Moines, Iowa  50266
Cancer Center of Kansas, PA - Dodge City Dodge City, Kansas  67801
Stormont-Vail Cancer Center Topeka, Kansas  66604
St. Francis Comprehensive Cancer Center Topeka, Kansas  66606
Cancer Center of Kansas, P.A. - Wellington Wellington, Kansas  67152
Associates in Womens Health, P.A. - North Review Wichita, Kansas  67203
Cancer Center of Kansas, P.A. - Winfield Winfield, Kansas  67156
Ochsner Clinic of Baton Rouge Baton Rouge, Louisiana  708169990
Terrebonne General Medical Center Houma, Louisiana  70360
Feist-Weiller Cancer Center at Louisiana State University Health Sciences Shreveport, Louisiana  71130-3932
Union Hospital Cancer Center at Union Hospital Elkton MD, Maryland  21921
Sturdy Memorial Hospital Attleboro, Massachusetts  02703
Franklin Medical Center Greenfield, Massachusetts  01301
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital Ann Arbor, Michigan  48106-0995
Bay Regional Medical Center Bay City, Michigan  48708
Mecosta County Medical Center Big Rapids, Michigan  49307
Green Bay Oncology, Limited - Iron Mountain Iron Mountain, Michigan  49801
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Mercy Memorial Hospital System Monroe, Michigan  48162
Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield, Michigan  48075
MeritCare Clinic - Bemidji Bemidji, Minnesota  56601
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Park Nicollet Health Services St. Louis Park, Minnesota  55416
Hattiesburg Clinic, P.A. Hattiesburg, Mississippi  39401
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Immanuel Medical Center Omaha, Nebraska  68122
Creighton University Medical Center Omaha, Nebraska  68131-2197
Booker Cancer Center at Riverview Medical Center Red Bank, New Jersey  07701
Fox Chase Cancer Center at St. Francis Medical Center Trenton, New Jersey  08629
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Charles R. Wood Cancer Center at Glens Falls Hospital Glens Falls, New York  12801
Wilson Medical Center Wilson, North Carolina  27893-3428
Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem, North Carolina  27103
Cancer Care Center at Medcenter One Hospital Bismarck, North Dakota  58501
Bismarck Cancer Center Bismarck, North Dakota  58501
St. Alexius Medical Center Bismarck, North Dakota  58502
Mid Dakota Clinic, P. C. Bismarck, North Dakota  58501
MeritCare Medical Group Fargo, North Dakota  58122
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
Good Samaritan Hospital Dayton, Ohio  45406
Blanchard Valley Medical Associates Findlay, Ohio  45840
Fremont Memorial Hospital Fremont, Ohio  43420
Community Oncology Group at Cleveland Clinic Cancer Center Independence, Ohio  44131
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
St. Charles Mercy Hospital Oregon, Ohio  43616
Firelands Regional Medical Center Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Promedica Cancer Center at Flower Hospital Sylvania, Ohio  43560
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Fulton County Health Center Wauseon, Ohio  43567
Cleveland Clinic - Wooster Wooster, Ohio  44691
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Comanche County Memorial Hospital Lawton, Oklahoma  73505
LaFortune Cancer Center at St. John Medical Center Tulsa, Oklahoma  74104
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center Portland, Oregon  97210
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
Delaware County Regional Cancer Center at Delaware County Memorial Hospital Drexel Hill, Pennsylvania  19026
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Hematology and Oncology Associates Scranton, Pennsylvania  18510
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Kingsport, Tennessee  37662
Doctor's Hospital of Laredo Laredo, Texas  78041
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Southwestern Vermont Regional Cancer Center Bennington, Vermont  05201
Mountainview Medical Berlin, Vermont  05602
Mount Ascutney Hospital Windsor, Vermont  05089
Danville Regional Medical Center Danville, Virginia  24541
Virginia Oncology Associates - Hampton Hampton, Virginia  23666
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
Green Bay Oncology, Limited at St. Vincent Hospital Green Bay, Wisconsin  54301-3526
Dean Medical Center - Fish Hatchery Madison, Wisconsin  53715
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks, Alaska  99701
DeCesaris Cancer Institute at Anne Arundel Medical Center Annapolis, Maryland  21401
St. Francis Hospital Federal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland, Washington  98034-3013
St. Clare Hospital Lakewood, Washington  98499-0998
Capital Medical Center Olympia, Washington  98502
Providence St. Peter Hospital Regional Cancer Center Olympia, Washington  98506
Good Samaritan Cancer Center Puyallup, Washington  98371
Valley Medical Center Renton, Washington  98055
St. Joseph Medical Center at Franciscan Health System Tacoma, Washington  98405-3004
Allenmore Hospital Tacoma, Washington  98411-0414
Miller-Dwan Medical Center Duluth, Minnesota  55805
Rice Memorial Hospital Willmar, Minnesota  56201
Pottstown Memorial Regional Cancer Center Pottstown, Pennsylvania  19464
Franciscan Skemp Healthcare La Crosse, Wisconsin  54601-4796
California Cancer Center - Woodward Park Office Fresno, California  93720
Providence Holy Cross Cancer Center Mission Hills, California  91346-9600
Middlesex Hospital Cancer Center Middletown, Connecticut  06457
Northeast Georgia Medical Center Gainesville, Georgia  30501
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Wendt Regional Cancer Center at Finley Hospital Dubuque, Iowa  52001
Mercy Cancer Center at Mercy Medical Center - North Iowa Mason City, Iowa  50401
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County Madisonville, Kentucky  42431
Central Maine Medical Center Lewiston, Maine  04240
Hudner Oncology Center at Saint Anne's Hospital Fall River, Massachusetts  02721
Great Lakes Cancer Institute at McLaren Regional Medical Center Flint, Michigan  48532
Cancer Care Center at St. Luke's Hospital Duluth, Minnesota  55805
Saint Francis Cancer Center Shakopee, Minnesota  55379
St. Joseph's Hospital St Paul, Minnesota  55102
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Washoe Cancer Services at Washoe Medical Center - Reno Reno, Nevada  89502
South Jersey Healthcare Regional Cancer Center Millville, New Jersey  08332
Capital Health System Regional Cancer Center Trenton, New Jersey  08618
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Altru Cancer Center at Altru Hospital Grand Forks, North Dakota  58201
Huron Hospital Cancer Care Center Cleveland, Ohio  44112
Euclid Hospital Cleveland, Ohio  44119
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford Salem, Ohio  44460
South Pointe Hospital Cancer Care Center Warrensville Heights, Ohio  44122
Cancer Treatment Center Wooster, Ohio  44691
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
St. Joseph Medical Center Reading, Pennsylvania  19604
Praxair Cancer Center at Danbury Hospital Danbury, Connecticut  06810
Carl and Dorothy Bennett Cancer Center at Stamford Hospital Stamford, Connecticut  06904
Florida Cancer Specialists - Sarasota Downtown Sarasota, Florida  34236
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405
Covenant Cancer Treatment Center Waterloo, Iowa  50702
Christ Hospital Cancer Center Cincinnati, Ohio  45219
Salem Hospital Regional Cancer Care Services Salem, Oregon  97309-5014
Schiffler Cancer Center at Wheeling Hospital Wheeling, West Virginia  26003
Oncology Alliance, SC - Milwaukee - East Glendale, Wisconsin  53212-1038
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Green Bay, Wisconsin  54311
Ministry Medical Group at Saint Mary's Hospital Rhinelander, Wisconsin  54501
Cancer Resource Center at King's Daughters Medical Center Ashland, Kentucky  41101
Methodist Cancer Center at Methodist Hospital - Omaha Omaha, Nebraska  68114
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Saint Louis University Cancer Center Saint Louis, Missouri  63110
Auburn Regional Center for Cancer Care Auburn, Washington  98002
Morton Plant Hospital Clearwater, Florida  33756
Community Hospital Munster, Indiana  46321
Alamance Cancer Center Burlington, North Carolina  27216
Memorial Hospital of Rhode Island Pawtucket, Rhode Island  02860
Sacred Heart Hospital Allentown, Pennsylvania  18102
Phoebe Cancer Center at Phoebe Putney Memorial Hospital Albany, Georgia  31702
Seton Shivers Cancer Program at Brackenridge Hospital Austin, Texas  78701
Saint Joseph's Mercy Cancer Center Hot Springs, Arkansas  71913
Washington Township Hospital Fremont, California  94538
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center Pomona, California  91767
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital Whittier, California  90602
Hematology Oncology Associates of Eastern Idaho Idaho Falls, Idaho  83404
Regional Cancer Institute at Bloomington Hospital Bloomington, Indiana  47403
Greater Baltimore Medical Center Baltimore, Maryland  21204
MetroWest Medical Center - Framingham Union Hospital Framingham, Massachusetts  01702
Caritas Norwood Hospital Norwood, Massachusetts  02062
Seacoast Cancer Center at Wentworth-Douglass Hospital Dover, New Hampshire  03820
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center Englewood, New Jersey  07631
AtlantiCare Regional Medical Center Pomona, New Jersey  08240
Tucker Center for Cancer Care at Orange Regional Medical Center Middletown, New York  10940-4199
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Moore Regional Community Hospital Comprehensive Cancer Center Pinehurst, North Carolina  28374
Bethesda North Hospital Cincinnati, Ohio  45242
Cancer Treatment Center at Good Samaritan Hospital Cincinnati, Ohio  45220
St. Joseph Cancer Center at St. Joseph Health Center Warren, Ohio  44484
Easton Regional Cancer Center at Easton Hospital Easton, Pennsylvania  18042
Mercy Cancer Institute at Mercy Hospital Pittsburgh, Pennsylvania  15219
York Cancer Center at Wellspan Health York, Pennsylvania  17403
Community Cancer Center at Rutland Regional Medical Center Rutland, Vermont  05701
Martha Jefferson Hospital Cancer Care Center Charlottesville, Virginia  22901
Theda Care Cancer Institute Appleton, Wisconsin  54911
Community Memorial Hospital Cancer Care Center Menomonee Falls, Wisconsin  53051
Regional Cancer Center - Erie Erie, Pennsylvania  16505
MedCentral - Mansfield Hospital Mansfield, Ohio  44903
Glendale Memorial Hospital Comprehensive Cancer Center Glendale, California  91204
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach Long Beach, California  90813
St. Vincent's Medical Center Jacksonville, Florida  32203
Resurrection Medical Center Chicago, Illinois  60631
Sherman Hospital Elgin, Illinois  60120-2198
Center for Cancer Care at Goshen Health System Goshen, Indiana  46526
Cancer Treatment Center at Christus Schumpert St. Mary Place Shreveport, Louisiana  71101
Frederick Memorial Hospital Regional Cancer Therapy Center Frederick, Maryland  21701
Jordan Hospital Club Cancer Center Plymouth, Massachusetts  02360
St. John's Regional Medical Center Joplin, Missouri  64804
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
Underwood Memorial Hospital Woodbury, New Jersey  08096
New Mexico Cancer Care Associates Santa Fe, New Mexico  87505-7670
Mercy Health Center Oklahoma City, Oklahoma  73120
McLeod Regional Medical Center Florence, South Carolina  29501
U.T. Cancer Institute at University of Tennessee Medical Center Knoxville, Tennessee  37920-2911
Presbyterian Hospital of Dallas Dallas, Texas  75231
St. Joseph Mercy Hospital Pontiac, Michigan  48341-2985
Huntsville Hospital Huntsville, Alabama  35807
Nalitt Cancer Institute at Staten Island University Hospital Staten Island, New York  10305
Sentara Cancer Institute at Sentara Norfolk General Hospital Norfolk, Virginia  23507
Arch Medical Services, Incorporated at Center for Cancer Care Research Saint Louis, Missouri  63141
Lakes Region General Hospital Laconia, New Hampshire  03246
St. Charles Medical Center - Bend Bend, Oregon  97701
PinnacleHealth Regional Cancer Center at Polyclinic Hospital Harrisburg, Pennsylvania  17105
Cancer Care Institute of Carolina at Aiken Regional Medical Centers Aiken, South Carolina  29801
Roper St. Francis Cancer Center at Roper Hospital Charleston, South Carolina  29401
Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center Boca Raton, Florida  33486
Lipson Cancer and Blood Center at Rochester General Hospital Rochester, New York  14621
Newton-Wellesley Hospital Newton, Massachusetts  02462
Woodwinds Health Campus Woodbury, Minnesota  55125
Cancer Center at Phoenixville Hospital Phoenixville, Pennsylvania  19460
Marshall University Medical Center Huntington, West Virginia  25701
Center for Cancer Care at OSF Saint Anthony Medical Center Rockford, Illinois  61108
Louisville Oncology at Norton Cancer Center Louisville, Kentucky  40202
Rappahannock General Hospital Kilmarnock, Virginia  22482
Desert Regional Medical Center Comprehensive Cancer Center Palm Springs, California  92262
Oncology Care Associates, PLLC Saint Joseph, Michigan  49085
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Mercy General Hospital Sacramento, California  95819
Alexian Brothers Radiation Oncology Elk Grove Village, Illinois  60007
Elmhurst Memorial Hospital Elmhurst, Illinois  60126
Iowa Blood and Cancer Care Cedar Rapids, Iowa  52402
Caritas St. Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Valley Hospital - Ridgewood Ridgewood, New Jersey  07450
Bay Area Hospital Coos Bay, Oregon  97420
St. Joseph's Hospital Health Center - Syracuse Syracuse, New York  13203
Dale and Frances Hughes Cancer Center at Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center Upland, Pennsylvania  19013
Watson Clinic, LLC Lakeland, Florida  33804-5000
John B. Amos Community Cancer Center Columbus, Georgia  31902
Provena St. Mary's Wasser Regional Cancer Center - Kankakee Kankakee, Illinois  60901
Lawrence Memorial Hospital of Medford Medford, Massachusetts  02155
St. Anthony's Cancer Center St. Louis, Missouri  63128
University of Wisconsin Cancer Center at Aspirus Wausau Hospital Wausau, Wisconsin  54401
Medical and Surgical Specialists, L L C Galesburg, Illinois  61401
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields Olympia Fields, Illinois  60461
Commonwealth Hematology-Oncology P. C. - Quincy Quincy, Massachusetts  02169
Ted B. Wahby Cancer Center at Mount Clemens General Hospital Mount Clemens, Michigan  48043
Lovelace Medical Center Albuquerque, New Mexico  87108
United States Air Force Medical Center Wright-Patterson Wright-Patterson Afb, Ohio  45433-5529
Providence Centralia Hospital Regional Cancer Center Centralia, Washington  98531
New York Oncology Hematology, P.C. Albany, New York  12208
St. Mary's Regional Cancer Center at St. Mary's Medical Center Huntington, West Virginia  25702
Ocean Medical Center at Meridian Health Brick, New Jersey  08724
High Point Regional Hospital High Point, North Carolina  27261
Augusta Oncology Associates - Walton Way Augusta, Georgia  30901
MaineGeneral Medical Center - Waterville Campus Waterville, Maine  04901
South Shore Hospital South Weymouth, Massachusetts  02190
Albert Lea Cancer Center at Albert Lea Medical Center Albert Lea, Minnesota  56007
Carson-Tahoe Cancer Services at Carson Tahoe Regional Healthcare Carson City, Nevada  89703
Parkland Oncology-Hematology Clinic at Parkland Medical Center Derry, New Hampshire  03038
Meadville Medical Center Meadville, Pennsylvania  16335
Ottumwa Regional Health Center Cancer Center Ottumwa, Iowa  52501
Erlanger Cancer Center Chattanooga, Tennessee  37403
Northeast Georgia Cancer Care, LLC Athens, Georgia  30607
All Saints Cancer Center at All Saints Medical Center Racine, Wisconsin  53405
Hematology Oncology Associates, PC Albuquerque, New Mexico  87106
NSMC Cancer Center - Peabody Peabody, Massachusetts  01960
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center Plattsburgh, New York  12901
Mercy Regional Cancer Center Janesville, Wisconsin  53547
Integris Oncology Services Oklahoma City, Oklahoma  73112
Fox Valley Surgical Associates at Appleton Medical Center Appleton, Wisconsin  54911-3454
East Alabama Medical Center Opelika, Alabama  36801-5452
Cancer Center at Providence Alaska Medical Center Anchorage, Alaska  99519-6604
Shore Regional Cancer Center at Memorial Hospital - Easton Easton, Maryland  21601
Mercy Medical Center Baltimore, Maryland  21202
Virginia K. Crosson Cancer Center at St. Jude Medical Center Fullerton, California  92835
Stevens Cancer Center at Scripps Memorial Hospital La Jolla, California  92037-1276
Robert and Carol Weissman Cancer Center at Martin Memorial Stuart, Florida  34994
Emory Crawford Long Hospital Atlanta, Georgia  30308
Portneuf Cancer Center at Portneuf Medical Center Pocatello, Idaho  83201
Delnor Community Hospital - Geneva Geneva, Illinois  60134
Methodist Cancer Center at Clarian Health Indianapolis, Indiana  46202
Arnett Cancer Care Lafayette, Indiana  47904
Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue Waterloo, Iowa  50702
Mount Carmel Regional Cancer Center Pittsburg, Kansas  66762
St. Mary's Hospital Leonardtown, Maryland  20650
Kaiser Permanente Capital Area Medical Group - Shady Grove Facility Rockville, Maryland  20850
Holy Cross Hospital Silver Spring, Maryland  20910
Cancer Institute at St. Joseph Medical Center Towson, Maryland  21204
Caritas Holy Family Hospital Methuen, Massachusetts  01844
Exeter Hospital Center for Cancer Care Exeter, New Hampshire  03833
Santa Fe Cancer Center at St. Vincent Hospital Santa Fe, New Mexico  87505
New York Oncology Hematology, PC at Albany Regional Cancer Care Albany, New York  12208
Amsterdam Community Cancer Program Amsterdam, New York  12010
Falck Cancer Center at Arnot Ogden Medical Center Elmira, New York  14905
New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program Hudson, New York  12534
Union State Bank Cancer Center at Nyack Hospital Nyack, New York  10960-1998
Riverview Cancer Care Medical Associates, PC Rexford, New York  12148
Genesee Surgical Associates - Linden Oaks Medical Campus Rochester, New York  14625
New York Oncology Hematology, P.C. - Ellis Office Schenectady, New York  12308
Samaritan Hospital at Northeast Health Troy, New York  12180
Oncology Hematology Care, Incorporated - Blue Ash Cincinnati, Ohio  45242
Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center Dubois, Pennsylvania  15801
Ephrata Cancer Center at Ephrata Community Hospital Ephrata, Pennsylvania  17522
Richard G. Laube Cancer Center at Armstrong County Memorial Hospital Kittanning, Pennsylvania  16201
Cancer Center at Riddle Memorial Hospital Media, Pennsylvania  19063
Chestnut Hill Healthcare Cancer Center Philadelphia, Pennsylvania  19118
Frankford Hospital - Torresdale Campus Philadelphia, Pennsylvania  19114
Baylor University Medical Center - Dallas Dallas, Texas  75246
Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County Martinsville, Virginia  24115
Peninsula Cancer Institute Newport News, Virginia  23601
Overlake Cancer Center at Overtake Hospital Medical Center Bellevue, Washington  98004
St. Mary Regional Cancer Center at St. Mary Medical Center Walla Walla, Washington  99362
Central Wisconsin Cancer Program at Agnesian HealthCare Fond du Lac, Wisconsin  54935
St. Joseph Regional Medical Center Milwaukee, Wisconsin  53210