A Phase I Study of the Safety, Tolerability, and Antitumor Activity of Escalating Doses of Intravenous CCI-779 Given in Combination With Escalating Doses of Interferon-Alpha to Patients With Advanced Renal Cancer
18 Years
N/A
Both
Kidney Cancer
Trial Information
A Phase I Study of the Safety, Tolerability, and Antitumor Activity of Escalating Doses of Intravenous CCI-779 Given in Combination With Escalating Doses of Interferon-Alpha to Patients With Advanced Renal Cancer
OBJECTIVES:
- Determine the maximum tolerated dose of CCI-779 in combination with interferon alfa in
patients with locally advanced or metastatic renal cell cancer.
- Determine the safety and tolerability of this regimen in these patients.
- Determine, preliminarily, any antitumor activity of this regimen in these patients.
- Determine the pharmacokinetics of this regimen in these patients.
OUTLINE: This is a dose-escalation, multicenter study.
Patients receive interferon alfa (IFN-A) subcutaneously 3 times a week. Beginning on week 2,
patients also receive CCI-779 IV over 30 minutes once weekly. Treatment continues in the
absence of disease progression or unacceptable toxicity.
Cohorts of at least 6 patients receive escalating doses of CCI-779 and then IFN-A until the
maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at
which at least 2 of 6 patients experience dose-limiting toxicity. Once the MTD is
determined, 20 additional patients are treated at that dose level.
Patients are followed at 30 days.
PROJECTED ACCRUAL: Approximately 50 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed locally advanced or metastatic renal cell cancer
- Progressive disease after treatment with 0-2 courses of immunotherapy,
chemotherapy, or other systemic therapy for advanced disease
- Measurable or evaluable disease
- No concurrent CNS metastases
- Prior CNS metastases allowed if no residual disease by MRI
PATIENT CHARACTERISTICS:
Age
- 18 and over
Performance status
- ECOG 0-1
Life expectancy
- At least 3 months
Hematopoietic
- Absolute neutrophil count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
- Hemoglobin at least 9 g/dL
Hepatic
- Bilirubin no greater than 1.5 mg/dL
- AST and ALT no greater than 3 times upper limit of normal (ULN) (5 times ULN if liver
metastases present)
Renal
- Creatinine less than 2 mg/dL OR
- Creatinine clearance at least 60 mL/min
Cardiovascular
- No unstable angina
- No myocardial infarction within the past 6 months
Other
- Cholesterol no greater than 350 mg/dL
- Triglycerides no greater than 400 mg/dL
- HIV negative
- Not immunocompromised
- No active autoimmune disorder
- No active infection requiring antibiotic therapy
- No other serious concurrent illness
- No known hypersensitivity to components of CCI-779, interferon alfa, diphenhydramine
hydrochloride, or both acetaminophen and nonsteroidal anti- inflammatory drugs
- No other major illness that would preclude study participation
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 3 months after study
participation
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Disease Characteristics
- At least 3 weeks since prior immunotherapy
- No prior interferon alfa
- No other concurrent immunotherapy
- No prophylactic growth factors
- Concurrent epoetin alfa allowed
Chemotherapy
- See Disease Characteristics
- At least 3 weeks since prior chemotherapy
- No prior CCI-779
- No other concurrent chemotherapy
Endocrine therapy
- No concurrent hormonal therapy for malignancy (megestrol for appetite loss allowed)
- Concurrent inhaled or replacement steroids allowed
Radiotherapy
- At least 3 weeks since prior radiotherapy
- No concurrent radiotherapy
Surgery
- At least 3 weeks since prior surgery
Other
- See Disease Characteristics
- At least 3 weeks since prior immunosuppressive agents
- At least 4 weeks since prior investigational agents
- No other concurrent investigational agents
- No concurrent immunosuppressive therapy
- No concurrent anticonvulsants known to be cytochrome P450 inducers, ketoconazole,
diltiazem, rifampin, terfenadine, cisapride, astemizole, or pimozide
- No concurrent maintenance therapy for life-threatening ventricular arrhythmia
Type of Study:
Interventional
Study Design:
Primary Purpose: Treatment
Principal Investigator
Robert J. Motzer, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Memorial Sloan-Kettering Cancer Center
Authority:
United States: Federal Government
Study ID:
02-023
NCT ID:
NCT00045370
Start Date:
April 2002
Completion Date:
November 2003
Related Keywords:
- Kidney Cancer
- recurrent renal cell cancer
- stage III renal cell cancer
- stage IV renal cell cancer
- Carcinoma, Renal Cell
- Kidney Neoplasms
Name | Location |
|---|---|
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
