Disease Characteristics:

- Patients with documented histologic and cytologic diagnosis of colon or rectal
malignancy

- Patients with documented status post surgical resection of primary cancer or
metastases

- Limited residual disease (i.e., CEA serum levels < 15 ng/mL and negative baseline CT
scans, or no lesion > 1 cm)

Prior/Concurrent Therapy:

- Patients must have completed chemotherapeutic agents, biologic therapy, radiotherapy,
other investigational therapy for cancer, or surgical procedures at least six weeks
prior to study entry.

- Patients must have recuperated from surgery and toxicities (as a result of previous
therapy) sufficiently prior to study entry

- Biologic Therapy: Patients who have received a murine, chimeric, CDR-grafted
(humanized), or human IgG will be eligible provided pre-study evaluations demonstrate
no significant reactivity with hMN-14 IgG (i.e., HAHA)

- Radiotherapy: No prior external beam irradiation to a field that includes more than
30% of the red marrow. No prior radiation to maximal tolerable levels for any
critical organs (e.g., 3000 cGy for the liver; 2000 cGy for the lungs and kidneys)

Patient Characteristics/

Inclusion Criteria:

- Performance Status: Patients with Karnofsky performance status > 70%

- Hematopoietic: ANC >/= 1.5 x 10/L; Hemoglobin >/= 10 g/dL; Platelets >/= 100 x 10/L

- Renal: Serum Creatinine
- Hepatic: Serum Bilirubin 2.5 x ULN

- Cardiovascular: Patients with LVEF >/= 50% by required MUGA/2D-ECHO tests

- Pulmonary: Patients with DF and FEV1 >/= 60% by required Pulmonary Function Tests

- Central Nervous System: Patients with known metastatic disease to the CNS are
excluded.

- Other: Patients agreeing to use a medically effective method of contraception during
and for a period of three months after the treatment period. A pregnancy test will be
preformed on each premenopausal female of childbearing potential immediately prior to
entry into study. Patients must understand and give written informed consent.