Cyclophosphamide And Doxorubicin (CA) (4 VS 6 Cycles) Versus Paclitaxel (4 VS 6 Cycles) As Adjuvant Therapy For Breast Cancer in Women With 0-3 Positive Axillary Lymph Nodes:A 2X2 Factorial Phase III Randomized Study
Phase 3
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Female
Breast Cancer
Female
Breast Cancer
Trial Information
Cyclophosphamide And Doxorubicin (CA) (4 VS 6 Cycles) Versus Paclitaxel (4 VS 6 Cycles) As Adjuvant Therapy For Breast Cancer in Women With 0-3 Positive Axillary Lymph Nodes:A 2X2 Factorial Phase III Randomized Study
OBJECTIVES:
Primary
- Compare the disease-free survival of women with operable breast cancer and 0-3 positive
axillary lymph nodes treated with two different schedules (4 vs 6 courses) of adjuvant
cyclophosphamide and doxorubicin vs paclitaxel. (Arms II and IV closed to accrual as of
1/30/2008)
- Compare the disease-free survival of patients treated with these regimens.
Secondary
- Compare overall survival, local control, and time to distant metastasis in patients
treated with these regimens.
- Compare the toxic effects of these regimens in these patients.
- Compare the effect of these regimens on the induction of menopause in premenopausal
patients.
- Determine the discrepancy of myelosuppression in patients with MDR1 haplotypes on the
CA treatment arm.
- Compare the disease-free survival of patients with MDR1 haplotypes treated with these
regimens.
- Correlate CYP3A5, CYP2C8, and CYP2B6 polymorphisms with disease-free survival and
toxicity in patients treated with these regimens.
OUTLINE: This is a randomized study. Patients are stratified according to menopausal status
(premenopausal vs postmenopausal), estrogen receptor (ER)/progesterone receptor (PR) status
(ER and/or PR positive or unknown vs ER and PR negative), and HER2/neu status (negative vs
unknown vs positive [by immunohistochemistry 3+ staining or gene amplification by
fluorescence in situ hybridization]). Patients are randomized to 1 of 4 treatment arms (arms
II and IV closed to accrual as of 1/30/2008).
- Arm I: Patients receive doxorubicin IV and cyclophosphamide IV on day 1. Treatment
repeats every 14 days for 4 courses.
- Arm II (closed to accrual as of 1/30/2008): Patients receive doxorubicin and
cyclophosphamide as in arm I. Treatment repeats every 14 days for 6 courses.
- Arm III: Patients receive paclitaxel IV over 1 hour on day 1. Treatment repeats every
14 days for 4 courses.
- Arm IV (closed to accrual as of 1/30/2008): Patients receive paclitaxel as in arm III.
Treatment repeats every 14 days for 6 courses.
Treatment in all arms continues in the absence of disease progression or unacceptable
toxicity.
Lumpectomy patients must then undergo radiotherapy. Mastectomy patients undergo radiotherapy
at the discretion of the treating physician.
Patients are followed every 6 months for 2 years and then annually for 15 years.
PROJECTED ACCRUAL: A total of 4,646 patients will be accrued for this study within 29
months.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed invasive carcinoma of the breast with 0-3 positive axillary
lymph nodes
- Meets 1 of the following criteria for node-negative disease:
- Negative sentinel lymph node biopsy
- At least 6 negative axillary lymph nodes removed and determined to be
negative by axillary dissection
- Meets 1 of the following criteria for node-positive disease (1-3 positive
axillary lymph nodes):
- At least 1 positive lymph node by sentinel lymph node biopsy AND at least 6
axillary lymph nodes removed by axillary dissection; of all the nodes
removed from both the sentinel lymph node biopsy and the axillary
dissection, 1-3 must be positive
- At least 6 lymph nodes removed by axillary dissection; 1-3 nodes from the
axillary dissection must be positive
- "High-risk" disease that warrants chemotherapy (ultimately determined by the treating
physician)
- Modified radical mastectomy or lumpectomy within the past 84 days required
- Negative tumor margins for invasive cancer and ductal carcinoma in situ (DCIS)
- Lobular carcinoma in situ (LCIS) at the margin allowed
- Multicentric disease allowed provided margins and axillary nodes are negative after
resection
- Bilateral synchronous disease allowed
- Invasive cancer on one side and DCIS or LCIS on the contralateral side is allowed
provided all other eligibility criteria are met
- No locally advanced, inflammatory, or metastatic breast cancer
- No dermal lymphatics involvement, even if there are no clinical signs of inflammatory
cancer
- HER2/neu positive, negative, or unknown
- Hormone receptor status:
- Any estrogen and/or progesterone receptor status
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Sex:
- Female
Menopausal status:
- Premenopausal or postmenopausal
Performance status:
- CTC 0-1
Life expectancy:
- Not specified
Hematopoietic:
- Absolute neutrophil count at least 1,000/mm^3
- Platelet count at least 100,000/mm^3
Hepatic:
- Bilirubin no greater than 1.5 times upper limit of normal
Renal:
- Creatinine no greater than 2.0 mg/dL
Cardiovascular:
- No active congestive heart failure
- No myocardial infarction within the past 6 months
Other:
- Not pregnant or nursing
- Fertile patients must use effective nonhormonal contraception during and for at least
2 months after study participation
- No other malignancy within the past 5 years except curatively treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- No prior trastuzumab (Herceptin^®) for this malignancy
Chemotherapy:
- See Disease Characteristics
- No prior chemotherapy for this malignancy
- No other concurrent chemotherapy
Endocrine therapy:
- No prior hormonal therapy for this malignancy except tamoxifen given for up to 4
weeks
- Prior tamoxifen or other selective estrogen receptor modulators (SERMs) for
prevention or other indications (e.g., osteoporosis) allowed
- No concurrent exogenous hormonal therapy (including oral contraceptives,
postmenopausal hormone replacement therapy, or raloxifene) except:
- Steroids for adrenal failure
- Hormonal agents for nondisease-related conditions (e.g., insulin for diabetes or
synthroid for hypothyroidism)
- Intermittent dexamethasone as an antiemetic and premedication for paclitaxel
- No concurrent tamoxifen or other SERMs
Surgery:
- See Disease Characteristics
Other:
- No concurrent dexrazoxane
- No concurrent raloxifene
- Concurrent bisphosphonates for osteoporosis allowed
- Concurrent trastuzumab (Herceptin^®) allowed for patients with HER2-positive disease
- Concurrent enrollment on adjuvant bisphosphonate studies allowed
- Concurrent enrollment on adjuvant hormonal studies allowed provided hormonal therapy
does not commence until completion of study chemotherapy
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Primary Purpose: Treatment
Outcome Measure:
Disease-free survival
Safety Issue:
No
Principal Investigator
Lawrence N. Shulman, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Dana-Farber Cancer Institute
Authority:
United States: Federal Government
Study ID:
CDR0000069444
NCT ID:
NCT00041119
Start Date:
May 2002
Completion Date:
Related Keywords:
- Breast Cancer
- stage IB breast cancer
- stage II breast cancer
- Breast Neoplasms
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
| Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
| Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
| Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois 60153-5500 |
| Walter Reed Army Medical Center | Washington, District of Columbia 20307-5000 |
| Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
| Duke Comprehensive Cancer Center | Durham, North Carolina 27710 |
| CCOP - Wichita | Wichita, Kansas 67214-3882 |
| Hurley Medical Center | Flint, Michigan 48503 |
| CCOP - Kansas City | Kansas City, Missouri 64131 |
| CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
| CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
| CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
| CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
| CCOP - Northern New Jersey | Hackensack, New Jersey 07601 |
| Aurora Presbyterian Hospital | Aurora, Colorado 80012 |
| Boulder Community Hospital | Boulder, Colorado 80301-9019 |
| Penrose Cancer Center at Penrose Hospital | Colorado Springs, Colorado 80933 |
| CCOP - Colorado Cancer Research Program | Denver, Colorado 80224-2522 |
| Porter Adventist Hospital | Denver, Colorado 80210 |
| Presbyterian - St. Luke's Medical Center | Denver, Colorado 80218 |
| St. Joseph Hospital | Denver, Colorado 80218 |
| Rose Medical Center | Denver, Colorado 80220 |
| Swedish Medical Center | Englewood, Colorado 80110 |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction, Colorado 81502 |
| Sky Ridge Medical Center | Lone Tree, Colorado 80124 |
| Hope Cancer Care Center at Longmont United Hospital | Longmont, Colorado 80502 |
| St. Mary - Corwin Regional Medical Center | Pueblo, Colorado 81004 |
| North Suburban Medical Center | Thornton, Colorado 80229 |
| Rush-Copley Cancer Care Center | Aurora, Illinois 60507 |
| Joliet Oncology-Hematology Associates, Limited - West | Joliet, Illinois 60435 |
| Carle Cancer Center at Carle Foundation Hospital | Urbana, Illinois 61801 |
| Saint Anthony Memorial Health Centers | Michigan City, Indiana 46360 |
| Cedar Rapids Oncology Associates | Cedar Rapids, Iowa 52403 |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
| Saint Joseph Mercy Cancer Center | Ann Arbor, Michigan 48106-0995 |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn, Michigan 48123-2500 |
| Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
| Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
| West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
| Borgess Medical Center | Kalamazooaa, Michigan 49001 |
| Sparrow Regional Cancer Center | Lansing, Michigan 48912-1811 |
| St. John Macomb Hospital | Warren, Michigan 48093 |
| MeritCare Bemidji | Bemidji, Minnesota 56601 |
| Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
| Duluth Clinic Cancer Center - Duluth | Duluth, Minnesota 55805-1983 |
| CCOP - Duluth | Duluth, Minnesota 55805 |
| Miller - Dwan Medical Center | Duluth, Minnesota 55805 |
| Fairview Southdale Hospital | Edina, Minnesota 55435 |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
| Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
| Minnesota Oncology Hematology, PA - Maplewood | Maplewood, Minnesota 55109 |
| HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota 55109 |
| Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota 55415 |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota 55407 |
| Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota 55422-2900 |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota 55379 |
| Park Nicollet Cancer Center | St. Louis Park, Minnesota 55416 |
| Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
| United Hospital | St. Paul, Minnesota 55102 |
| Ridgeview Medical Center | Waconia, Minnesota 55387 |
| Minnesota Oncology Hematology, PA - Woodbury | Woodbury, Minnesota 55125 |
| MeritCare Broadway | Fargo, North Dakota 58122 |
| CCOP - MeritCare Hospital | Fargo, North Dakota 58122 |
| Aultman Cancer Center at Aultman Hospital | Canton, Ohio 44710-1799 |
| Mercy Cancer Center at Mercy Medical Center | Canton, Ohio 44708 |
| Case Comprehensive Cancer Center | Cleveland, Ohio 44106-5065 |
| MetroHealth Cancer Care Center at MetroHealth Medical Center | Cleveland, Ohio 44109 |
| St. Rita's Medical Center | Lima, Ohio 45801 |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa, Oklahoma 74136 |
| Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey, Pennsylvania 17033-0850 |
| Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls, South Dakota 57117-5039 |
| Medical X-Ray Center, PC | Sioux Falls, South Dakota 57105 |
| Dean Medical Center - Madison | Madison, Wisconsin 53717 |
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | Madison, Wisconsin 53792-6164 |
| Marshfield Clinic - Marshfield Center | Marshfield, Wisconsin 54449 |
| Marshfield Clinic - Indianhead Center | Rice Lake, Wisconsin 54868 |
| CCOP - Ochsner | New Orleans, Louisiana 70121 |
| Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
| CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
| Memorial Hospital of South Bend | South Bend, Indiana 46601 |
| Cape Cod Hospital | Hyannis, Massachusetts 02601 |
| CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
| CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
| CCOP - Columbus | Columbus, Ohio 43206 |
| CCOP - Dayton | Kettering, Ohio 45429 |
| Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
| Grand View Hospital | Sellersville, Pennsylvania 18960 |
| CCOP - Greenville | Greenville, South Carolina 29615 |
| Harrington Cancer Center | Amarillo, Texas 79106 |
| CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
| Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
| UMASS Memorial Cancer Center - University Campus | Worcester, Massachusetts 01605-2982 |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
| CCOP - Columbia River Oncology Program | Portland, Oregon 97225 |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington 98405 |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore, Maryland 21231-2410 |
| Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles, California 90033-0804 |
| MBCCOP - LSU Health Sciences Center | New Orleans, Louisiana 70112 |
| CCOP - St. Louis-Cape Girardeau | Saint Louis, Missouri 63141 |
| CCOP - Virginia Mason Research Center | Seattle, Washington 98101 |
| CCOP - Northwest | Tacoma, Washington 98405-0986 |
| Naval Medical Center - San Diego | San Diego, California 92134-3202 |
| Kent County Memorial Hospital | Warwick, Rhode Island 02886 |
| Peninsula Regional Medical Center | Salisbury, Maryland 21801 |
| Rebecca and John Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
| University of California Davis Cancer Center | Sacramento, California 95817 |
| Elmhurst Hospital Center | Elmhurst, New York 11373 |
| Queens Cancer Center of Queens Hospital | Jamaica, New York 11432 |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
| Medical Center of Central Georgia | Macon, Georgia 31201 |
| St. Vincent Mercy Medical Center | Toledo, Ohio 43608 |
| Palmetto Health South Carolina Cancer Center | Columbia, South Carolina 29203 |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington 98104 |
| Thompson Cancer Survival Center | Knoxville, Tennessee 37916 |
| Maine Center for Cancer Medicine and Blood Disorders - Scarborough | Scarborough, Maine 04074 |
| Overlook Hospital | Summit, New Jersey 07902-0220 |
| Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
| St. John's Regional Health Center | Springfield, Missouri 65804 |
| Carol G. Simon Cancer Center at Morristown Memorial Hospital | Morristown, New Jersey 07962 |
| UMDNJ University Hospital | Newark, New Jersey 07103 |
| CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha, Wisconsin 53188 |
| University of Florida Shands Cancer Center | Gainesville, Florida 32610-0232 |
| Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando, Florida 32803-1273 |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas 67214 |
| Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
| Albert Einstein Cancer Center at Albert Einstein College of Medicine | Bronx, New York 10461 |
| Mount Sinai Medical Center | New York, New York 10029 |
| Stony Brook University Cancer Center | Stony Brook, New York 11794-8174 |
| SUNY Upstate Medical University Hospital | Syracuse, New York 13210 |
| Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
| Medical University of Ohio Cancer Center | Toledo, Ohio 43614 |
| Toledo Hospital | Toledo, Ohio 43606 |
| Rhode Island Hospital Comprehensive Cancer Center | Providence, Rhode Island 02903 |
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas, Texas 75390 |
| Carilion Cancer Center of Western Virginia | Roanoke, Virginia 24029 |
| Providence Cancer Center at Sacred Heart Medical Center | Spokane, Washington 99220-2555 |
| Edwards Comprehensive Cancer Center at Cabell Huntington Hospital | Huntington, West Virginia 25701 |
| Lahey Clinic Medical Center - Burlington | Burlington, Massachusetts 01805 |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester, New York 14642 |
| Our Lady of Mercy Medical Center Comprehensive Cancer Center | Bronx, New York 10466 |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
| Lewistown Hospital | Lewistown, Pennsylvania 17044 |
| Mount Nittany Medical Center | State College, Pennsylvania 16803 |
| Sibley Memorial Hospital | Washington, District of Columbia 20016 |
| Hematology Oncology Associates of the Quad Cities | Bettendorf, Iowa 52722 |
| Somerset Medical Center | Somerville, New Jersey 08876 |
| Batte Cancer Center at Northeast Medical Center | Concord, North Carolina 28025 |
| North Colorado Medical Center | Greeley, Colorado 80631 |
| McKee Medical Center | Loveland, Colorado 80539 |
| Saint Anthony's Hospital at Saint Anthony's Health Center | Alton, Illinois 62002 |
| Good Samaritan Regional Health Center | Mt. Vernon, Illinois 62864 |
| Southwest Medical Center | Liberal, Kansas 67901 |
| Northern Michigan Hospital | Petoskey, Michigan 49770 |
| William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan 48073 |
| David C. Pratt Cancer Center at St. John's Mercy | St. Louis, Missouri 63141 |
| Northern Rockies Radiation Oncology Center | Billings, Montana 59101 |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings, Montana 59101 |
| St. Peter's Hospital | Helena, Montana 59601 |
| Glacier Oncology, PLLC | Kalispell, Montana 59901 |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula, Montana 59802 |
| Montana Cancer Specialists at Montana Cancer Center | Missoula, Montana 59802 |
| Community Medical Center | Missoula, Montana 59801 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
| Adena Regional Medical Center | Chillicothe, Ohio 54601 |
| Doctors Hospital at Ohio Health | Columbus, Ohio 43228 |
| Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
| Grady Memorial Hospital | Delaware, Ohio 43015 |
| Fairfield Medical Center | Lancaster, Ohio 43130 |
| Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
| Community Hospital of Springfield and Clark County | Springfield, Ohio 45505 |
| Olympic Hematology and Oncology | Bremerton, Washington 98310 |
| Skagit Valley Hospital Cancer Care Center | Mt. Vernon, Washington 98273 |
| University Cancer Center at University of Washington Medical Center | Seattle, Washington 98195 |
| Group Health Central Hospital | Seattle, Washington 98104 |
| Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore, Maryland 21201 |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha, Nebraska 68198-7680 |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood, Florida 33021 |
| Zimmer Cancer Center at New Hanover Regional Medical Center | Wilmington, North Carolina 28402-9025 |
| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise, Idaho 83712-6297 |
| University of Illinois Cancer Center | Chicago, Illinois 60612-7243 |
| Advocate Lutheran General Cancer Care Center | Park Ridge, Illinois 60068-1174 |
| Swedish-American Regional Cancer Center | Rockford, Illinois 61104-2315 |
| CancerCare of Maine at Eastern Maine Medical Center | Bangor, Maine 04401 |
| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Masonic Cancer Center at University of Minnesota | Minneapolis, Minnesota 55455 |
| University of Mississippi Cancer Clinic | Jackson, Mississippi 39216-4505 |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
| CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
| Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center | New York, New York 10032 |
| Oklahoma University Cancer Institute | Oklahoma City, Oklahoma 73104 |
| Legacy Emanuel Hospital and Health Center and Children's Hospital | Portland, Oregon 97227 |
| Madigan Army Medical Center - Tacoma | Tacoma, Washington 98431 |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin 54601 |
| Methodist Estabrook Cancer Center | Omaha, Nebraska 68114-4199 |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
| Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois 62526 |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
| Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford, Connecticut 06102-5037 |
| Elkhart General Hospital | Elkhart, Indiana 46515 |
| Howard Community Hospital | Kokomo, Indiana 46904 |
| South Bend Clinic | South Bend, Indiana 46617 |
| Lakeland Regional Cancer Care Center - St. Joseph | St. Joseph, Michigan 49085 |
| Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
| Fox Chase Cancer Center - Philadelphia | Philadelphia, Pennsylvania 19111-2497 |
| Lakeland Regional Cancer Center at Lakeland Regional Medical Center | Lakeland, Florida 33805 |
| University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
| Joan Karnell Cancer Center at Pennsylvania Hospital | Philadelphia, Pennsylvania 19107 |
| UPMC Cancer Centers | Pittsburgh, Pennsylvania 15232 |
| Peninsula Medical Center | Burlingame, California 94010 |
| Sutter Health - Western Division Cancer Research Group | Greenbrae, California 94904 |
| Marin Cancer Institute at Marin General Hospital | Greenbrae, California 94904 |
| Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
| Valley Care Medical Center | Pleasanton, California 94588 |
| California Pacific Medical Center - California Campus | San Francisco, California 94118 |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter, Florida 33458 |
| Swedish Covenant Hospital | Chicago, Illinois 60625 |
| Hematology and Oncology Associates | Chicago, Illinois 60611 |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey, Illinois 60426 |
| Midwest Center for Hematology/Oncology | Joliet, Illinois 60432 |
| St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana 46107 |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne, Indiana 46815 |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
| St. Luke's Hospital | Cedar Rapids, Iowa 52402 |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
| Genesis Regional Cancer Center at Genesis Medical Center | Davenport, Iowa 52803 |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
| Mercy Capitol Hospital | Des Moines, Iowa 50307 |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines, Iowa 50309 |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines, Iowa 50314 |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
| Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas 67801 |
| St. Francis Comprehensive Cancer Center | Topeka, Kansas 66606 |
| Pennington Cancer Center at Baton Rouge General | Baton Rouge, Louisiana 70806 |
| Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge, Louisiana 70809 |
| Medical Center of Louisiana - New Orleans | New Orleans, Louisiana 70112 |
| Sturdy Memorial Hospital | Attleboro, Massachusetts 02703 |
| Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan 49221 |
| Community Cancer Center of Monroe | Monroe, Michigan 48162 |
| CentraCare Clinic - River Campus | St. Cloud, Minnesota 56303 |
| Saint Francis Medical Center | Cape Girardeau, Missouri 63701 |
| Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | Grand Island, Nebraska 68803 |
| Immanuel Medical Center | Omaha, Nebraska 68122 |
| Creighton University Medical Center | Omaha, Nebraska 68131-2197 |
| Kingsbury Center for Cancer Care at Cheshire Medical Center | Keene, New Hampshire 03431 |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
| Highland Hospital of Rochester | Rochester, New York 14620 |
| Iredell Memorial Hospital | Statesville, North Carolina 28677 |
| Bismarck Cancer Center | Bismarck, North Dakota 58501 |
| Wood County Oncology Center | Bowling Green, Ohio 43402 |
| Samaritan North Cancer Care Center | Dayton, Ohio 45415 |
| Grandview Hospital | Dayton, Ohio 45405 |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
| Good Samaritan Hospital | Dayton, Ohio 45406 |
| Blanchard Valley Medical Associates | Findlay, Ohio 45840 |
| Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
| Lima Memorial Hospital | Lima, Ohio 45804 |
| St. Luke's Hospital | Maumee, Ohio 43537 |
| Northwest Ohio Oncology Center | Maumee, Ohio 43537 |
| Middletown Regional Hospital | Middletown, Ohio 45044 |
| Toledo Clinic - Oregon | Oregon, Ohio 43616 |
| St. Charles Mercy Hospital | Oregon, Ohio 43616 |
| North Coast Cancer Care, Incorporated | Sandusky, Ohio 44870 |
| Mercy Medical Center | Springfield, Ohio 45504 |
| Mercy Hospital of Tiffin | Tiffin, Ohio 44883 |
| Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio 43623 |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio 45373-1300 |
| Fulton County Health Center | Wauseon, Ohio 43567 |
| Cleveland Clinic - Wooster | Wooster, Ohio 44691 |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio 45385 |
| Legacy Mount Hood Medical Center | Gresham, Oregon 97030 |
| Providence Milwaukie Hospital | Milwaukie, Oregon 97222 |
| Kaiser Permanente Health Care - Portland | Portland, Oregon 97232 |
| Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon 97213-2967 |
| Providence St. Vincent Medical Center | Portland, Oregon 97225 |
| Legacy Meridian Park Hospital | Tualatin, Oregon 97062 |
| Oncology Services of Aberdeen | Aberdeen, South Dakota 57401 |
| Virginia Oncology Associates - Hampton | Hampton, Virginia 23666 |
| Minor and James Medical, PLLC | Seattle, Washington 98104 |
| Polyclinic First Hill | Seattle, Washington 98122 |
| Providence Cancer Center at Holy Family Hospital | Spokane, Washington 99207 |
| Southwest Washington Medical Center Cancer Center | Vancouver, Washington 98668 |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima, Washington 98902 |
| Holy Family Memorial Medical Center Cancer Care Center | Manitowoc, Wisconsin 54221-1450 |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan, Wyoming 82801 |
| Massachusetts General Hospital | Boston, Massachusetts 02114-2617 |
| Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital | Fairbanks, Alaska 99701 |
| St. Anthony Central Hospital | Denver, Colorado 80204-1335 |
| Exempla Lutheran Medical Center | Wheat Ridge, Colorado 80033 |
| St. Francis Hospital | Federal Way, Washington 98003 |
| Cascade Cancer Center at Evergreen Hospital Medical Center | Kirkland, Washington 98034-3013 |
| St. Clare Hospital | Lakewood, Washington 98499-0998 |
| Providence St. Peter Hospital Regional Cancer Center | Olympia, Washington 98506 |
| Good Samaritan Cancer Center | Puyallup, Washington 98371 |
| Valley Medical Center | Renton, Washington 98055 |
| Allenmore Hospital | Tacoma, Washington 98411-0414 |
| Lancaster General Hospital | Lancaster, Pennsylvania 17604-3555 |
| Hembree Mercy Cancer Center at St. Edward Mercy Medical Center | Ft. Smith, Arkansas 72903 |
| California Cancer Center - Woodward Park Office | Fresno, California 93720 |
| Highland General Hospital | Oakland, California 94602 |
| Northeast Georgia Medical Center | Gainesville, Georgia 30501 |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago, Illinois 60657 |
| Regional Cancer Center at Singing River Hospital | Pascagoula, Mississippi 39581 |
| Saint Luke's Hospital | Chesterfield, Missouri 63017 |
| Missouri Baptist Cancer Center | St. Louis, Missouri 63131 |
| Cancer Resource Center - Lincoln | Lincoln, Nebraska 68510 |
| Randolph Hospital | Asheboro, North Carolina 27203 |
| Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro, North Carolina 27401 |
| Annie Penn Cancer Center | Reidsville, North Carolina 27320 |
| Altru Cancer Center at Altru Hospital | Grand Forks, North Dakota 58201 |
| Allegheny Cancer Center at Allegheny General Hospital | Pittsburgh, Pennsylvania 15212 |
| St. Joseph Medical Center | Reading, Pennsylvania 19604 |
| Midelfort Clinic - Luther | Eau Claire, Wisconsin 54702 |
| UAB Comprehensive Cancer Center | Birmingham, Alabama 35294 |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley, California 94704 |
| Eastern Connecticut Hematology and Oncology Associates | Norwich, Connecticut 06360 |
| Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware 19958 |
| Herbert D. Kerman Regional Oncology Center - Daytona Beach | Daytona Beach, Florida 32114 |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
| John B. Amos Cancer Center | Columbus, Georgia 31904 |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah, Georgia 31405 |
| Elkhart Clinic, LLC | Elkhart, Indiana 46514-2098 |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka, Indiana 46545-1470 |
| Reid Hospital & Health Care Services | Richmond, Indiana 47374 |
| McFarland Clinic, PC | Ames, Iowa 50010 |
| Cancer Center of Kansas, PA - Chanute | Chanute, Kansas 66720 |
| Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas 67042 |
| Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
| Cancer Center of Kansas, PA - Kingman | Kingman, Kansas 67068 |
| Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
| Cancer Center of Kansas, PA - Newton | Newton, Kansas 67114 |
| Menorah Medical Center | Overland Park, Kansas 66209 |
| Cancer Center of Kansas, PA - Parsons | Parsons, Kansas 67357 |
| Cancer Center of Kansas, PA - Pratt | Pratt, Kansas 67124 |
| Cancer Center of Kansas, PA - Salina | Salina, Kansas 67401 |
| Shawnee Mission Medical Center | Shawnee Mission, Kansas 66204 |
| Cotton-O'Neil Cancer Center | Topeka, Kansas 66606 |
| Cancer Center of Kansas, PA - Wellington | Wellington, Kansas 67152 |
| Cancer Center of Kansas, PA - Wichita | Wichita, Kansas 67214 |
| Associates in Womens Health, PA - North Review | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Winfield | Winfield, Kansas 67156 |
| Ochsner Health Center - Bluebonnet | Baton Rouge, Louisiana 70809 |
| Union Hospital Cancer Program at Union Hospital | Elkton MD, Maryland 21921 |
| Foote Memorial Hospital | Jackson, Michigan 49201 |
| Haematology-Oncology Associates of Ohio and Michigan, PC | Lambertville, Michigan 48144 |
| St. Mary Mercy Hospital | Livonia, Michigan 48154 |
| Mercy Memorial Hospital - Monroe | Monroe, Michigan 48162 |
| St. Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron, Michigan 48060 |
| Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw, Michigan 48601 |
| Lakeside Cancer Specialists, PLLC | Saint Joseph, Michigan 49085 |
| St. Luke's Hospital Cancer Care Center | Duluth, Minnesota 55805 |
| Fergus Falls Medical Group, PA | Fergus Falls, Minnesota 56537 |
| Truman Medical Center - Hospital Hill | Kansas City, Missouri 64108 |
| St. Joseph Medical Center | Kansas City, Missouri 64114 |
| Heartland Hematology Oncology Associates, Incorporated | Kansas City, Missouri 64118 |
| North Kansas City Hospital | Kansas City, Missouri 64116 |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
| Research Medical Center | Kansas City, Missouri 64132 |
| Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
| Arch Medical Services, Incorporated at Center for Cancer Care and Research | Saint Louis, Missouri 63141 |
| Billings Clinic - Downtown | Billings, Montana 59107-7000 |
| Bozeman Deaconess Cancer Center | Bozeman, Montana 59715 |
| St. James Healthcare Cancer Care | Butte, Montana 59701 |
| Great Falls Clinic - Main Facility | Great Falls, Montana 59405 |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls, Montana 59405 |
| Kalispell Medical Oncology at KRMC | Kalispell, Montana 59901 |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha, Nebraska 68124 |
| Leo W. Jenkins Cancer Center at ECU Medical School | Greenville, North Carolina 27834 |
| Summa Center for Cancer Care at Akron City Hospital | Akron, Ohio 44309-2090 |
| Barberton Citizens Hospital | Barberton, Ohio 44203 |
| North Coast Cancer Care - Clyde | Clyde, Ohio 43410 |
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | Columbus, Ohio 43210-1240 |
| Grant Medical Center Cancer Care | Columbus, Ohio 43215 |
| Wayne Hospital | Greenville, Ohio 45331 |
| Fisher-Titus Medical Center | Norwalk, Ohio 44857 |
| Flower Hospital Cancer Center | Sylvania, Ohio 43560 |
| St. Anne Mercy Hospital | Toledo, Ohio 43623 |
| Mount Carmel St. Ann's Cancer Center | Westerville, Ohio 43081 |
| Clinton Memorial Hospital | Wilmington, Ohio 45177 |
| Cleo Craig Cancer Research Clinic | Lawton, Oklahoma 73505 |
| Cancer Care Associates - Mercy Campus | Oklahoma City, Oklahoma 73120 |
| Adventist Medical Center | Portland, Oregon 97216 |
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | Portland, Oregon 97210 |
| Hematology and Oncology Associates of Northeastern Pennsylvania | Scranton, Pennsylvania 18510 |
| Fredericksburg Oncology, Incorporated | Fredericksburg, Virginia 22401 |
| St. Joseph Cancer Center | Bellingham, Washington 98225 |
| Providence Centralia Hospital | Centralia, Washington 98531-9027 |
| Columbia Basin Hematology | Kennewick, Washington 99336 |
| Harrison Poulsbo Hematology and Onocology | Poulsbo, Washington 98370 |
| Evergreen Hematology and Oncology, PS | Spokane, Washington 99218 |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington 98405-3004 |
| Wenatchee Valley Medical Center | Wenatchee, Washington 98801-2028 |
| Marshfield Clinic - Chippewa Center | Chippewa Falls, Wisconsin 54729 |
| Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin 54701 |
| Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn | Elkhorn, Wisconsin 53121 |
| Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay, Wisconsin 54311 |
| UW Cancer Center Johnson Creek | Johnson Creek, Wisconsin 53038 |
| Vince Lombardi Cancer Clinic - Marinette | Marinette, Wisconsin 54143 |
| Saint Joseph's Hospital | Marshfield, Wisconsin 54449 |
| Medical Consultants, Limited | Milwaukee, Wisconsin 53215 |
| Marshfield Clinic - Lakeland Center | Minocqua, Wisconsin 54548 |
| Ministry Medical Group at Saint Mary's Hospital | Rhinelander, Wisconsin 54501 |
| Vince Lombardi Cancer Clinic - Sheboygan | Sheboygan, Wisconsin 53081 |
| Saint Michael's Hospital Cancer Center | Stevens Point, Wisconsin 54481 |
| Aurora Medical Center | Summit, Wisconsin 53066 |
| Vince Lombardi Cancer Clinic - Two Rivers | Two Rivers, Wisconsin 54241 |
| Marshfield Clinic - Wausau Center | Wausau, Wisconsin 54401 |
| Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids, Wisconsin 54494 |
| Cancer Resource Center at King's Daughters Medical Center | Ashland, Kentucky 41101 |
| Mid Dakota Clinic, PC | Bismarck, North Dakota 58501 |
| Regional Cancer Center at Memorial Medical Center | Springfield, Illinois 62781-0001 |
| Auburn Regional Center for Cancer Care | Auburn, Washington 98002 |
| Memorial Hospital of Rhode Island | Pawtucket, Rhode Island 02860 |
| Aurora Sinai Medical Center | Milwaukee, Wisconsin 53201-0342 |
| Washington Township Hospital | Fremont, California 94538 |
| Lowell General Hospital | Lowell, Massachusetts 01854 |
| Caritas Norwood Hospital | Norwood, Massachusetts 02062 |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney, Nebraska 68848-1990 |
| Elliot Regional Cancer Center at Elliot Hospital | Manchester, New Hampshire 03103 |
| Pardee Memorial Hospital | Hendersonville, North Carolina 28791 |
| Three Rivers Community Hospital | Grants Pass, Oregon 97527 |
| Dubs Cancer Center at Rogue Valley Medical Center | Medford, Oregon 97504 |
| Martha Jefferson Hospital Cancer Care Center | Charlottesville, Virginia 22901 |
| Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin 53066 |
| Harold Alfond Center for Cancer Care | Augusta, Maine 04330 |
| Dana-Farber/Brigham and Women's Cancer Center | Boston, Massachusetts 02115 |
| Kinston Medical Specialists | Kinston, North Carolina 28501 |
| Miriam Hospital | Providence, Rhode Island 02906 |
| St. Francis Hospital | Evanston, Illinois 60202 |
| Frederick Memorial Hospital Regional Cancer Therapy Center | Frederick, Maryland 21701 |
| St. John's Regional Medical Center | Joplin, Missouri 64804 |
| McLeod Regional Medical Center | Florence, South Carolina 29501 |
| MBCCOP - Meharry Medical College - Nashville | Nashville, Tennessee 37208-3599 |
| Palm Beach Cancer Institute - West Palm Beach | West Palm Beach, Florida 33401 |
| Great Falls, Montana 59405 | |
| Lakes Region General Hospital | Laconia, New Hampshire 03246 |
| Roper St. Francis Cancer Center at Roper Hospital | Charleston, South Carolina 29401 |
| Rockwood Clinic Cancer Treatment Center | Spokane, Washington 99204-2967 |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland, New Jersey 08360 |
| Lipson Cancer and Blood Center at Rochester General Hospital | Rochester, New York 14621 |
| Center for Cancer Care at OSF Saint Anthony Medical Center | Rockford, Illinois 61108 |
| Doctors Medical Center - San Pablo Campus | San Pablo, California 94806 |
| St. Vincent Healthcare Cancer Care Services | Billings, Montana 59101 |
| Center for Cancer Care and Research at Watson Clinic, LLP | Lakeland, Florida 33805 |
| Berkshire Hematology Oncology, PC | Pittsfield, Massachusetts 01201 |
| Parvin Radiation Oncology | Kansas City, Missouri 64116 |
| Midwest Hematology Oncology Group, Incorporated | Saint Louis, Missouri 63109 |
| Lynchburg Hematology-Oncology Clinic | Lynchburg, Virginia 24501 |
| Providence Cancer Center at Providence Hospital | Mobile, Alabama 36608 |
| East Bay Radiation Oncology Center | Castro Valley, California 94546 |
| Contra Costa Regional Medical Center | Martinez, California 94553-3156 |
| Tibotec Therapeutics - Division of Ortho Biotech Products, LP | Marysville, California 95901 |
| Memorial Medical Center | Modesto, California 95355 |
| Tom K Lee, Incorporated | Oakland, California 94609 |
| Bay Area Breast Surgeons, Incorporated | Oakland, California 94609 |
| Valley Medical Oncology Consultants - Pleasanton | Pleasanton, California 94588 |
| Tahoe Forest Cancer Center | Truckee, California 96161 |
| Alexian Brothers Radiation Oncology | Elk Grove Village, Illinois 60007 |
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline, Illinois 61265 |
| Iowa Blood and Cancer Care | Cedar Rapids, Iowa 52402 |
| Caritas St. Elizabeth's Medical Center | Brighton, Massachusetts 02135-2997 |
| Hattiesburg Clinic, PA at Forrest General | Hattiesburg, Mississippi 39401 |
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord, New Hampshire 03301 |
| Center for Cancer Care at Exeter Hospital | Exeter, New Hampshire 03833 |
| New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett, New Hampshire 03106 |
| Faxton Regional Cancer Center | Utica, New York 13502 |
| Trinity CancerCare Center | Minot, North Dakota 58701 |
| United States Air Force Medical Center - Wright-Patterson | Wright-Patterson AFB, Ohio 45433-5529 |
| Franciscan Skemp Healthcare - La Crosse Campus | La Crosse, Wisconsin 54601 |
| Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields | Olympia Fields, Illinois 60461 |
| Medcenter One Hospital Cancer Care Center | Bismarck, North Dakota 58501 |
| St. Alexius Medical Center Cancer Center | Bismarck, North Dakota 58502 |
| Providence Cancer Center at PMCC | Medford, Oregon 97504 |
| Callahan Cancer Center at Great Plains Regional Medical Center | North Platte, Nebraska 69103 |
| Regional Medical Center | Anniston, Alabama 36202 |
| Valley Medical Oncology Consultants - Castro Valley | Castro Valley, California 94546 |
| Valley Medical Oncology | Fremont, California 94538 |
| Cancer Care Associates | Fresno, California 93720 |
| Mercy Regional Cancer Center at Mercy Medical Center | Redding, California 96049 |
| Memorial Hospital Cancer Center - Colorado Springs | Colorado Springs, Colorado 80909 |
| Integrated Community Oncology Network - Orange Park | Orange Park, Florida 32073 |
| Mount Sinai Hospital Medical Center | Chicago, Illinois 60608 |
| Provena St. Mary's Regional Cancer Center - Kankakee | Kankakee, Illinois 60901 |
| Heartland Oncology and Hematology | Council Bluffs, Iowa 51503 |
| Ochsner Health Center - Covington | Covington, Louisiana 70433 |
| Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River, Massachusetts 02721 |
| Addison Gilbert Hospital | Gloucester, Massachusetts 01930 |
| NSMC Cancer Center - Peabody | Peabody, Massachusetts 01960 |
| Noble Hospital | Westfield, Massachusetts 01085 |
| Immanuel St. Joseph's | Mankato, Minnesota 56002 |
| Hematology & Oncology Clinic | Hattiesburg, Mississippi 39402 |
| Skaggs Cancer Center at Skaggs Regional Medical Center | Branson, Missouri 65616 |
| Dana-Farber Cancer Institute at Londonderry | Londonderry, New Hampshire 03053 |
| Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center | Plattsburgh, New York 12901 |
| Alamance Cancer Center at Alamance Regional Medical Center | Burlington, North Carolina 27216 |
| Cape Fear Valley Medical Center Cancer Center | Fayetteville, North Carolina 28302-2000 |
| Maria Parham Medical Center | Henderson, North Carolina 27536 |
| Southeastern Regional Medical Center | Lumberton, North Carolina 28359 |
| Granville Medical Center | Oxford, North Carolina 27565 |
| Duke Health Raleigh Hospital | Raleigh, North Carolina 27609 |
| Person Memorial Hospital | Roxboro, North Carolina 27573 |
| Marion L. Shepard Cancer Center at Beaufort County Hospital | Washington, North Carolina 27889 |
| Nashville Oncology Associates, PC | Nashville, Tennessee 37203 |
| Virginia Cancer Institute - West End | Richmond, Virginia 23230 |
| Luther Midlelfort Hospital | Eau Claire, Wisconsin 54702 |
| Mercy Regional Cancer Center | Janesville, Wisconsin 53547 |
| Columbia Saint Mary's Hospital - Ozaukee | Mequon, Wisconsin 53097 |
| Columbia-Saint Mary's Cancer Care Center | Milwaukee, Wisconsin 53211 |
