Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed metastatic breast cancer

- Received at least 2 prior courses of paclitaxel-based chemotherapy at doses between
175-200 mg/m^2 (given over 3 hours every 3 weeks) or docetaxel-based chemotherapy at
doses between 75-100 mg/m^2 (given over 1 hour every 3 weeks) as most recent
anticancer therapy

- Evidence of disease resistance

- Progressive disease as best response OR

- Transient response or disease stabilization followed by progression during
taxane-based treatment

- Disease progression on a combination of a taxane and another cytotoxic agent
allowed

- Unidimensionally measurable disease

- At least 1 target lesion that clearly progressed or developed during prior
taxane therapy

- Lesions stable or responsive to prior taxane therapy are not considered target
lesions

- Lesions that have been irradiated within the past 3 months are not considered
target lesions unless they have clearly progressed or appeared since
radiotherapy

- No bone metastases as only site of measurable disease

- No rapidly progressive visceral metastases

- No symptomatic CNS metastases

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Sex:

- Not specified

Menopausal status:

- Not specified

Performance status:

- WHO 0-2

Life expectancy:

- Not specified

Hematopoietic:

- Neutrophil count at least 1,500/mm^3

- Platelet count at least 100,000/mm^3

Hepatic:

- Bilirubin no greater than 1.5 times upper limit of normal (ULN)

- Transaminases no greater than 2.5 times ULN (5 times ULN if liver metastases present)

Renal:

- Creatinine no greater than 1.5 times ULN

- Calcium normal

Cardiovascular:

- LVEF normal by echocardiogram (ECG) or MUGA scan

- QTc less than 450 sec on baseline ECG

- No prior clinically significant arrhythmias requiring treatment

- No cardiac infarction

- No atrial ventricular enlargement or hypertrophy

Other:

- No prior toxicity to paclitaxel that would preclude study dose and schedule

- Sodium, potassium, chloride, and bicarbonate normal

- No pre-existing neuropathy greater than grade 2

- No other prior or concurrent malignancy except adequately treated carcinoma in situ
of the cervix, contralateral breast cancer, or nonmelanoma skin cancer or cancer that
has been in remission for more than 5 years

- Not pregnant or nursing

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- No concurrent anticancer biologic agents

Chemotherapy:

- See Disease Characteristics

- No more than 8 weeks since last course of prior taxane-based chemotherapy

- No more than 2 prior chemotherapy regimens for metastatic breast cancer

- No other concurrent anticancer chemotherapy

Endocrine therapy:

- No concurrent anticancer hormonal therapy

Radiotherapy:

- See Disease Characteristics

- No concurrent radiotherapy

Surgery:

- Not specified

Other:

- No prior multi-drug resistance inhibitor

- No new anticancer therapy initiation since last course of prior taxane-based
chemotherapy

- No concurrent angiotensin converting enzyme inhibitor and/or drugs that may prolong
the QTc interval

- No other concurrent anticancer therapy

- Concurrent bisphosphonates for treatment and prevention of bony metastases allowed
provided drugs were initiated prior to study (treatment of hypercalcemia due to
malignancy allowed regardless of time of initiation)