Inclusion Criteria

DISEASE CHARACTERISTICS: Diagnosis of adenocarcinoma of the pancreas Unresectable disease
by exploratory laparotomy Involvement of the superior mesenteric artery or occlusion of
the superior mesenteric vein-portal vein confluence No extrapancreatic metastases by
ultrasound, CT scan, or laparotomy Tumor must be accessible for direct injection of study
drug and placement of electrode array

PATIENT CHARACTERISTICS: Age: Any age Performance status: Karnofsky 70-100% Life
expectancy: Not specified Hematopoietic: Not specified Hepatic: AST and ALT no greater
than 3 times upper limit of normal No impaired hepatic function Renal: Creatinine no
greater than 1.5 mg/dL No impaired renal function Cardiovascular: No impaired cardiac
function Pulmonary: No compromised pulmonary function No pulmonary condition that would
potentially require the use of high FIO2 levels Other: Not pregnant or nursing Negative
pregnancy test Fertile patients must use effective contraception during and for 6 months
after study No prior reaction to bleomycin No fever, infection, or other medical condition
that would preclude study Not at high risk for complications associated with abdominal
surgery

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior lifetime
cumulative dose of bleomycin greater than 400 U Endocrine therapy: Not specified
Radiotherapy: Not specified Surgery: See Disease Characteristics