Phase I and Clinical Pharamcologic Study of 10-Propargyl-10-Deazaaminopterin (PDX) in Combination With Probenecid in Adults With Advanced Solid Tumors

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed cancer that is potentially incurable by standard
chemotherapy, radiotherapy, or surgical procedures

- Failed prior first-line therapy (patients are also eligible if no effective
first-line therapy exists)

- Previously treated or clinically stable brain metastases are allowed

- No leukemia or lymphoma

- No clinically significant pleural effusions or ascites

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- Karnofsky 70-100%

Life expectancy:

- Not specified

Hematopoietic:

- WBC at least 4,000/mm^3

- Platelet count at least 160,000/mm^3

- Hemoglobin greater than 10 g/dL

- Serum and RBC folate normal

Hepatic:

- Bilirubin no greater than 1.5 mg/dL

- SGOT or SGPT less than 2 times upper limit of normal

Renal:

- Creatinine no greater than 1.2 mg/dL OR

- Creatinine clearance at least 60 mL/min

Cardiovascular:

- No unstable angina

- No congestive heart failure

- No cardiac arrhythmia

Other:

- Homocysteine normal

- No grade III or IV edema

- Not pregnant or nursing

- Fertile patients must use effective contraception during and for 6 months after study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- See Disease Characteristics

- At least 3 weeks since prior chemotherapy (4 weeks for nitrosoureas or mitomycin) and
recovered

Endocrine therapy:

- Not specified

Radiotherapy:

- See Disease Characteristics

- At least 3 weeks since prior radiotherapy to bone marrow-containing areas and
recovered

Surgery:

- See Disease Characteristics

- No prior pneumonectomy

Other:

- No concurrent folic acid or potentially nephrotoxic agents