Phase II Study of Paclitaxel and Estramustine Phosphate in Patients With Relapsed Non-Hodgkin's Lymphoma

Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed relapsed or refractory intermediate,
high-grade, or transformed non-Hodgkin's lymphoma Received 1-3 prior treatment regimens
(cytoreductive chemotherapy followed by high-dose therapy with stem cell support
considered 1 regimen) Measurable disease A new classification scheme for adult
non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or
"aggressive" lymphoma will replace the terminology of "low", "intermediate", or "high"
grade lymphoma. However, this protocol uses the former terminology.

PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-2 Life expectancy: At
least 12 weeks Hematopoietic: Granulocyte count greater than 1,500/mm3* Platelet count
greater than 75,000/mm3* * Unless due to lymphomatous marrow involvement Hepatic:
Bilirubin less than 1.5 mg/dL* SGOT/SGPT less than 2 times normal* * Unless due to
lymphomatous involvement Renal: Creatinine less than 2.0 mg/dL* OR Creatinine clearance
greater than 50 mL/min* * Unless due to lymphomatous involvement Cardiovascular: No active
uncontrolled angina pectoris No New York Heart Association class II-IV heart disease No
myocardial infarction within the past 6 months No history of recurrent deep venous
thrombosis not associated with catheter placement Other: No other prior malignancy within
the past 5 years except curatively treated cervical cancer or basal cell or squamous cell
skin cancer No serious concurrent medical illness that would preclude study No active
infection

PRIOR CONCURRENT THERAPY: Biologic therapy: See Disease Characteristics Chemotherapy: See
Disease Characteristics At least 4 weeks since prior chemotherapy and recovered No prior
paclitaxel, docetaxel, or estramustine Endocrine therapy: Not specified Radiotherapy: At
least 4 weeks since prior radiotherapy and recovered Surgery: Not specified