Effects of a Low Fat Diet on Serum Factors and Prostate Cancer
- Compare the inhibition of growth of human prostate cancer cell lines by serum from
patients with prostate cancer before and after being fed a low fat, high fiber diet.
- Determine the underlying mechanism through which a low fat, high fiber diet affects the
growth of prostate cancer cell lines.
- Determine whether a low fat, high fiber diet inhibits the growth of prostate cancer
cell lines through androgen-dependent and/or androgen- independent mechanisms in these
- Determine the growth factors, hormones, and/or binding proteins that may be responsible
for affecting the growth of prostate cancer cell lines in these patients.
OUTLINE: This is a randomized study. Patients are randomized to 1 of 2 arms.
- Arm I: Patients receive a low fat, high fiber diet daily for 3 weeks.
- Arm II: Patients receive a control diet containing the standard amounts of fat and
PROJECTED ACCRUAL: A total of 40 patients (20 per arm) will be accrued for this study within
Allocation: Randomized, Primary Purpose: Prevention
William Aronson, MD
Jonsson Comprehensive Cancer Center
United States: Federal Government
|Jonsson Comprehensive Cancer Center, UCLA
|Los Angeles, California 90095-1781