Inclusion Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Histologically or cytologically confirmed adenocarcinoma of
the pancreas or ampullae of vater not amenable to curative surgery Metastases confined to
abdominal cavity May include peripancreatic lymph nodes, peritoneal carcinomatosis, and
hepatic metastases Extrapancreatic disease must be resectable Must have progressive
disease if received any prior therapy No distant metastases, including lung or bone
metastases --Prior/Concurrent Therapy-- Biologic therapy: No concurrent immunotherapy for
pancreatic cancer Chemotherapy: No prior gemcitabine or fluorouracil Endocrine therapy: No
concurrent hormonal therapy for pancreatic cancer Radiotherapy: No prior radiotherapy for
pancreatic cancer No prior abdominal or pelvic radiotherapy Surgery: See Disease
Characteristics Other: At least 30 days since prior anticancer therapy and recovered
--Patient Characteristics-- Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
Not specified Hematopoietic: Absolute neutrophil count greater than 2,000/mm3 Platelet
count greater than 100,000/mm3 Hepatic: SGOT and SGPT less than 4 times upper limit of
normal No active hepatitis Renal: Creatinine less than 1.5 mg/dL OR Creatinine clearance
greater than 60 mL/min Cardiovascular: No significant reversible ischemic changes in wall
motion or perfusion with stress (correction using angiography and angioplasty allowed) No
significant resting left ventricle dysfunction No unstable angina No New York Heart
Association class III or IV heart disease No myocardial infarction within past 6 months
Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective
contraception No active disease increasing possibility of infection, including AIDS and
other autoimmune disorders No other medical condition or psychiatric disease that would
preclude study No other concurrent malignancy except nonmelanoma skin cancer or carcinoma
in situ of the cervix