Prospective Comparison of Air Contrast Barium Enema (ACBE), Computed Tomographic Colonography (Virtual Colonoscopy) and Colonoscopy for Evaluation of the Colon in Patients With Fecal Occult Blood
- Compare the accuracy of air contrast barium enema, computed tomographic colonography
(virtual colonoscopy), and colonoscopy for the detection of colonic lesions in patients
with factors related to colon cancer.
- Compare the patient experience during each of these imaging tests.
OUTLINE: This is a multicenter study.
A repeat fecal occult blood test is performed. Patients then undergo an air contrast barium
enema (ACBE). At 7-10 days after ACBE, patients undergo a computed tomographic colonography
(virtual colonoscopy) followed by a colonoscopy on the same day.
A repeat ACBE may be performed if there is a discrepancy between the initial ACBE and
colonoscopy. If the repeat ACBE continues to show an abnormality, patients undergo a second
Within 24 hours of completion of each test, patients fill out a questionnaire about their
experience. At 5-7 days after completion of all tests, patients complete a final
questionnaire comparing all 3 tests.
PROJECTED ACCRUAL: A total of 2,133 patients will be accrued for this study within 4 years.
Primary Purpose: Diagnostic
Don Rockey, MD
Duke Cancer Institute
United States: Federal Government
|University of Chicago Cancer Research Center||Chicago, Illinois 60637|
|Duke Comprehensive Cancer Center||Durham, North Carolina 27710|
|Simmons Cancer Center - Dallas||Dallas, Texas 75235-9154|
|NYU School of Medicine's Kaplan Comprehensive Cancer Center||New York, New York 10016|
|University of Texas Medical Branch||Galveston, Texas 77555-1329|
|Massey Cancer Center||Richmond, Virginia 23298-0037|
|Veterans Affairs Medical Center - San Francisco||San Francisco, California 94121|
|Veterans Affairs Medical Center - Durham||Durham, North Carolina 27705|
|Rebecca and John Moores UCSD Cancer Center||La Jolla, California 92093-0658|
|Robert Wood Johnson Medical School||New Brunswick, New Jersey 08903|
|California Pacific Medical Center - California Campus||San Francisco, California 94118|
|California Pacific Medical Center - Pacific Campus||San Francisco, California 94115|
|Indian River Radiology||Vero Beach, Florida 32960|
|Troy Internal Medicine, P.C.||Troy, Michigan 48098|