A Phase I Trial of Farnesyltransferase Inhibitor BMS-214662 (NSC 710086) Escalating to a 24 Hour Continuous Intravenous Infusion in Patients With Solid Tumors
18 Years
N/A
Both
Unspecified Adult Solid Tumor, Protocol Specific
Trial Information
A Phase I Trial of Farnesyltransferase Inhibitor BMS-214662 (NSC 710086) Escalating to a 24 Hour Continuous Intravenous Infusion in Patients With Solid Tumors
PRIMARY OBJECTIVES:
I. To establish the maximum tolerated dose (MTD) and identify the dose limiting toxicities
(DLT) of the investigational agent BMS-214662 when escalated to a 24-hour continuous
intravenous infusion every 7 days for 3 consecutive weeks to patients with solid tumors who
have failed curative or survival prolonging therapy or for who no such therapies exist.
II. To establish and assess the safety of an appropriate dose for Phase II studies.
III. To characterize the pharmacokinetics of BMS-214662 in patients when escalated to a
24-hour continuous IV infusion.
IV. To assess the extent and duration of farnesyltransferase inhibition in peripheral blood
mononuclear cells and other relevant surrogate markers of pharmacological activity.
SECONDARY OBJECTIVES:
I. To describe any preliminary evidence of antitumor activity. II. To establish
pharmacodynamic relationships for the pharmacological effect of the drug upon surrogate
markers of activity and host toxicity.
III. To compare the toxicity profiles for the 1 hour IV infusion and 24 hr continuous IV
infusion administration schedules, assuming that the 24 hr infusion schedule is feasible.
OUTLINE: This is a dose-prolongation, dose-escalation study.
Single patient cohorts receive BMS-214662 IV over escalating periods of 2, 4, 8, 16, and 24
hours weekly for 3 weeks followed by 1 week of rest. If no patient experiences dose-limiting
toxicity (DLT), dose escalation proceeds in the single patient cohorts.
Treatment repeats every 4 weeks for at least 2 courses in the absence of disease progression
or unacceptable toxicity. Individual patient cohorts may increase their duration of
BMS-214662 infusion in subsequent courses to the current duration safely reached.
Beginning with the infusion level at which DLT is first encountered by a single patient,
cohorts of 3-6 patients receive escalating doses of BMS-214662 until the maximum tolerated
dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2
of 6 patients experience DLT. An additional cohort of 10 patients is treated at the MTD.
Patients are followed for at least 4 weeks.
PROJECTED ACCRUAL: A total of 20-40 patients will be accrued for this study within 9-12
months.
Inclusion Criteria:
- Metastatic or inoperable malignancy, other than leukemia or a primary CNS tumor, for
which there is no known curative or survival prolonging palliative therapy, or
failure of these therapies
- Life expectancy >= 2 months
- ECOG performance status 0-1
- ANC >= 1,500/mm^3
- Platelets >= 100,000/mm^3
- SGOT and SGPT =< 2.5 times the upper limit of normal (ULN)
- Total bilirubin =< ULN
- Serum creatinine =< ULN
- Calculated or measured creatinine clearances (Cockcroft-Gault formula) >= 50
ml/minute
- >= 3 weeks since major surgery
- >= 4 weeks since chemotherapy or radiation therapy
- No uncontrolled serious medical or psychiatric illness
- Women of childbearing potential must not be pregnant or lactating; all women of
childbearing potential must have a negative serum or urine pregnancy test (minimum
sensitivity 25 IU/L of beta-HCG) within 72 hr prior to receiving the study
medication; BMS 214662 has antiproliferative effects which may be harmful to the
developing fetus or nursing infant
- Fertile males and females must use adequate contraception
- Signed informed consent
Exclusion Criteria:
- Any history of clinically significant atrial or ventricular arrhythmias, any history
of second or third degree heart block, or prolonged QTc interval (greater than 450
ms) on electrocardiogram
- Active brain metastases including evidence of cerebral edema by CT scan or MRI, or
progression from prior imaging study, any requirement for steroids, or clinical
symptoms of/from brain metastases
- Received any drugs within 7 days prior to receiving study drug therapy, which are
known to be substrates of cytochrome P450-3A4 (CYP3A4)
- Patients should not receive concurrent therapy with known CYP3A4 substrates while on
study and for at least 1 week following the last dose of BMS-214662; this is due to
the CYP3A4 inhibitory potential of BMS-214662; a representative list of commonly
prescribed known CYP3A4 substrates includes: terfenadine, astemizole, triazolam,
midazolam, cisapride, bepridil, rifabutin, simvastatin, lovastatin, and propafenone
- Patients receiving therapy with BMS-214662 should not receive concomitant therapy
with NSAIDs or other potentially nephrotoxic medications for at least 2 days before
and after administration of BMS-214662
- Patients with known pre-existing renal disease are not eligible
Type of Study:
Interventional
Study Design:
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Maximum tolerated dose (MTD) of BMS-214662, based on the National Cancer Institute Common Toxicity Criteria (NCI CTC) v2.0
Outcome Time Frame:
Up to 28 days
Safety Issue:
Yes
Principal Investigator
Joseph Eder
Investigator Role:
Principal Investigator
Investigator Affiliation:
Dana-Farber Cancer Institute
Authority:
United States: Food and Drug Administration
Study ID:
NCI-2013-00032
NCT ID:
NCT00006242
Start Date:
July 2000
Completion Date:
Related Keywords:
- Unspecified Adult Solid Tumor, Protocol Specific
- Neoplasms
Name | Location |
|---|---|
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
