N/A
N/A
54 Years
N/A
54 Years
Not Enrolling
Both
Fanconi's Anemia, Myelodysplastic Syndromes, Leukemia, Nonlymphocytic, Acute, Leukemia, Lymphocytic, Acute
Both
Fanconi's Anemia, Myelodysplastic Syndromes, Leukemia, Nonlymphocytic, Acute, Leukemia, Lymphocytic, Acute
Trial Information
PROTOCOL OUTLINE:
Patients receive cyclophosphamide IV over 1-2 hours on day -6 through -3 and total body
radiotherapy on day -1. Patients undergo allogeneic bone marrow transplantation on day 0.
Inclusion Criteria
- Diagnosis of Fanconi's anemia with the family history and typical phenotype
including: Short stature Hypoplastic radii Skin pigmentation Renal anomalies
Chromosomal fragility
- Evidence of Fanconi's myelodysplastic syndrome Bone marrow dysplasia of all 3 marrow
cell lines AND Clonal cytogenetic abnormalities demonstrable in marrow cells
- First complete remission following therapy for Fanconi's acute leukemia allowed
- Must have related histocompatible donor No evidence of excessive in vitro chromosome
fragility typical of Fanconi's anemia Normal CBC and bone marrow
Type of Study:
Interventional
Study Design:
Primary Purpose: Treatment
Principal Investigator
Daniel J. Weisdorf
Investigator Role:
Study Chair
Investigator Affiliation:
Fairview University Medical Center
Authority:
Unspecified
Study ID:
199/15100
NCT ID:
NCT00005892
Start Date:
March 2000
Completion Date:
Related Keywords:
- Fanconi's Anemia
- Myelodysplastic Syndromes
- Leukemia, Nonlymphocytic, Acute
- Leukemia, Lymphocytic, Acute
- Fanconi's anemia
- acute leukemia
- acute lymphocytic leukemia
- acute myeloid leukemia
- acute undifferentiated leukemia
- adult acute lymphoblastic leukemia
- adult acute lymphoblastic leukemia in remission
- adult acute myeloid leukemia
- adult acute myeloid leukemia in remission
- aplastic anemia
- childhood acute lymphoblastic leukemia
- childhood acute lymphoblastic leukemia in remission
- childhood acute myeloid leukemia
- childhood acute myeloid leukemia in remission
- de novo myelodysplastic syndrome
- hematologic disorders
- hematopoietic/lymphoid cancer
- leukemia
- myelodysplastic syndrome
- oncologic disorders
- previously treated myelodysplastic syndrome
- rare disease
- secondary myelodysplastic syndrome
- Anemia
- Fanconi Anemia
- Fanconi Syndrome
- Leukemia
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Leukemia, Myeloid, Acute
- Myelodysplastic Syndromes
- Preleukemia
Name | Location |
|---|---|
| Fairview University Medical Center | Minneapolis, Minnesota 55455 |
