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Pediatric Low Grade Astrocytoma: Treatment Guidance

Phase 2
12 Years
Open (Enrolling)
Brain and Central Nervous System Tumors

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Trial Information

Pediatric Low Grade Astrocytoma: Treatment Guidance

OBJECTIVES: I. Determine if tumor growth rate can be decreased by targeting areas of
increased choline activity, as measured by magnetic resonance spectroscopic imaging, in
pediatric patients with progressive low grade astrocytoma treated with surgical resection
and/or focal radiotherapy. II. Improve the quality of life without use of aggressive surgery
or radiotherapy in this patient population.

OUTLINE: Patients undergo magnetic resonance spectroscopic imaging (MRSI) over 60 minutes
prior to surgery and/or radiotherapy. Patients are assigned to one of two treatment arms
based on tumor accessibility and may crossover to either arm. Arm I: Patients undergo
conventional surgery. Arm II: Patients with inaccessible tumors undergo focal radiotherapy.
Following surgery and/or radiotherapy, patients are followed every 4 months for up to 2
years with MRSI or MRI for tumor response and growth.

PROJECTED ACCRUAL: A total of 24 patients will be accrued for this study over 2 years.

Inclusion Criteria

DISEASE CHARACTERISTICS: Diagnosis of low grade astrocytoma in the hypothalamus, brain
stem, or thalamus of 5 cm on T2 weighted scans Incomplete surgical resection Previously
treated with evidence of tumor progression No hemispheric or cerebellar masses

PATIENT CHARACTERISTICS: Age: 12 and under Performance status: Not specified Life
expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not

PRIOR CONCURRENT THERAPY: See Disease Characteristics

Type of Study:


Study Design:

Primary Purpose: Treatment

Principal Investigator

Jeffry Alger, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Jonsson Comprehensive Cancer Center


United States: Federal Government

Study ID:




Start Date:

February 1999

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • childhood low-grade cerebral astrocytoma
  • childhood low-grade cerebellar astrocytoma
  • recurrent childhood cerebral astrocytoma
  • Astrocytoma
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms



Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California  90095-1781