Autologous Blood Stem Cell Transplantation in Patients With Hodgkin's Disease and Non-Hodgkin's Lymphoma With High-Dose Cyclophosphamide, Total Body Irradiation and Involved-Field Radiation Therapy
OBJECTIVES: I. Determine the toxicity of autologous peripheral blood stem cell
transplantation following involved field radiotherapy, high dose cyclophosphamide, and total
body irradiation in patients with recurrent or refractory Hodgkin's disease or non-Hodgkin's
lymphoma. II. Determine the response in patients treated with this regimen.
OUTLINE: Patients undergo involved field radiotherapy on days -16 to -7. Patients receive
cyclophosphamide IV over 2 hours on days -6 and -5. Patients undergo total body irradiation
twice daily on days -4 to -1. Autologous peripheral blood stem cells are reinfused on day 0.
Patients are followed every month for 1 year.
PROJECTED ACCRUAL: Not specified
Primary Purpose: Treatment
Jane N. Winter, MD
Robert H. Lurie Cancer Center
United States: Federal Government
|Robert H. Lurie Comprehensive Cancer Center, Northwestern University||Chicago, Illinois 60611|