Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed primary myelodysplastic syndrome (MDS)
with greater than 10% bone marrow blasts Refractory anemia with excess blasts (RAEB) OR
RAEB in transformation No chronic myelomonocytic leukemia No secondary MDS after prior
chemotherapy except if treatment was for acute myeloid leukemia No allogeneic bone marrow
transplantation planned

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: At
least 3 months Hematopoietic: Hemoglobin no greater than 10 g/dL OR transfusion
requirement of at least 3 packs of RBCs per month OR Platelet count less than 50,000/mm3
OR Absolute neutrophil count less than 1,000/mm3 No disseminated intravascular coagulation
defined as fibrinogen less than 100 mg/dL AND prolonged PT, PTT, or thrombin time AND
platelet count less than 25,000/mm3 without transfusion Hepatic: Bilirubin no greater than
2.0 mg/dL Alkaline phosphatase no greater than 4 times upper limit of normal (ULN) (unless
due to underlying disease or Gilbert's syndrome) SGPT and SGOT no greater than 4 times ULN
(unless due to underlying disease or Gilbert's syndrome) Renal: Creatinine no greater than
2.0 mg/dL Cardiovascular: No uncontrolled hypertension No congestive heart failure,
cardiac arrhythmia, or angina pectoris No history of myocardial infarction within the past
6 months No other significant cardiovascular disease LVEF within normal range by MUGA or
echocardiogram No active ischemia Pulmonary: No pulmonary dysfunction Other: No central or
peripheral neuropathy No uncontrolled or unstable diabetes No other significant organ
system dysfunction HIV negative No prior malignancy except basal cell carcinoma or
carcinoma in situ of the uterus No active, uncontrolled infection Not pregnant or nursing
Fertile patients must use effective contraception during and for 3 months after study

PRIOR CONCURRENT THERAPY: Biologic therapy: See Disease Characteristics At least 2 months
since prior biologic therapy (e.g., hematopoietic growth factors or biological response
modifiers) Chemotherapy: See Disease Characteristics At least 2 months since prior
chemotherapy Endocrine therapy: At least 2 months since prior endocrine therapy
Radiotherapy: At least 2 months since prior radiotherapy Concurrent radiotherapy allowed
Surgery: At least 2 months since prior surgery Other: No other concurrent investigational
drugs