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Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer

Phase 3
35 Years
Not Enrolling
Breast Cancer

Thank you

Trial Information

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer


- Determine whether raloxifene is more or less effective than tamoxifen in significantly
reducing the incidence rate of invasive breast cancer in postmenopausal women.

- Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal
carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart
disease, fractures of the hip and spine, or Colles' fractures of the wrist in these

- Evaluate the toxic effects of these regimens in these participants.

- Determine the effect of these regimens on the quality of life of these participants (at
selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)

OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to
49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in
situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive
breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs
5.0 or greater). Participants are randomized to 1 of 2 arms.

- Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.

- Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of
life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42,
48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective

Participants are followed annually after 5 years.

PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5

Inclusion Criteria


- Postmenopausal women at increased risk for developing invasive breast cancer, who
meet one of the following criteria:

- At least 12 months since spontaneous menstrual bleeding

- Prior documented hysterectomy and bilateral salpingo-oophorectomy

- At least 55 years of age with prior hysterectomy with or without oophorectomy

- Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of
ovaries unknown with documented follicle-stimulating hormone level demonstrating
elevation in postmenopausal range

- Histologically confirmed lobular carcinoma in situ treated by local excision only OR
a minimum projected 5 year probability of invasive breast cancer of at least 1.66%,
using Breast Cancer Risk Assessment Profile

- No clinical evidence of malignancy on physical exam within the past 180 days

- No evidence of suspicious or malignant disease on bilateral mammogram within the past

- No bilateral or unilateral prophylactic mastectomy

- No prior invasive breast cancer or intraductal carcinoma in situ

- Hormone receptor status:

- Not specified



- 35 and over


- Female

Menopausal status:

- See Disease Characteristics

Performance status:

- No restricted normal activity for a significant portion of each day

Life expectancy:

- At least 10 years


- Granulocyte count at least 1,500/mm^3

- Complete blood count and differential normal

- Platelet count normal


- SGOT or SGPT normal

- Bilirubin normal

- Alkaline phosphatase normal


- Creatinine normal


- No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or
uncontrolled hypertension

- No deep vein thrombosis


- No pulmonary embolus


- No other prior malignancy within the past 5 years except basal cell or squamous cell
skin cancer or carcinoma in situ of the cervix

- No concurrent nonmalignant disease that would preclude administration of tamoxifen or

- No clinical depression, psychiatric condition, or addictive disorder

- No uncontrolled diabetes


Biologic therapy:

- Not specified


- Not specified

Endocrine therapy:

- At least 3 months since prior estrogen or progesterone replacement therapy, oral
contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin
inhibitors, or antiandrogens

- At least 3 months since prior tamoxifen, raloxifene, or other selective
estrogen-receptor modulators of less than 3 months duration

- Concurrent Estring allowed


- No prior breast radiotherapy


- See Disease Characteristics


- No prior systemic adjuvant therapy for breast cancer

- No other participation in a cancer prevention or osteoporosis prevention study
involving pharmacologic intervention(s)

- NSABP-P-1 patients who received placebo are eligible

- No concurrent warfarin or cholestyramine

- Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or
bisphosphonates) allowed

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Outcome Measure:

Incidence of invasive breast cancer; superiority of one of the therapies.

Outcome Description:

Determine which of the following is true: compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer; compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.

Outcome Time Frame:

Time from randomization to the occurance of invasive breast cancer.

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Study Chair

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

May 1999

Completion Date:

August 2012

Related Keywords:

  • Breast Cancer
  • breast cancer
  • Breast Neoplasms



Baylor College of Medicine Houston, Texas  77030
Suburban Hospital Bethesda, Maryland  20814
Roswell Park Cancer Institute Buffalo, New York  14263
Fred Hutchinson Cancer Research Center Seattle, Washington  98109
Memorial Sloan-Kettering Cancer Center New York, New York  10021
University of Texas - MD Anderson Cancer Center Houston, Texas  77030-4009
St. Vincent Medical Center - Los Angeles Los Angeles, California  90057
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan  48109-0752
Mayo Clinic - Jacksonville Jacksonville, Florida  32224
Mayo Clinic Cancer Center Rochester, Minnesota  55905
Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood, Illinois  60153-5500
Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California  90095-1781
H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida  33612
MBCCOP - Hawaii Honolulu, Hawaii  96813
University of Chicago Cancer Research Center Chicago, Illinois  60637
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201
Duke Comprehensive Cancer Center Durham, North Carolina  27710
Cleveland Clinic Cancer Center Cleveland, Ohio  44195
Ireland Cancer Center Cleveland, Ohio  44106-5065
Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio  43210
Abington Memorial Hospital Abington, Pennsylvania  19001
Fox Chase Cancer Center Philadelphia, Pennsylvania  19111
CCOP - Upstate Carolina Spartanburg, South Carolina  29303
CCOP - Wichita Wichita, Kansas  67214-3882
Hurley Medical Center Flint, Michigan  48503
Presbyterian Healthcare Charlotte, North Carolina  28233-3549
Rhode Island Hospital Providence, Rhode Island  02903
University of Texas Health Science Center at San Antonio San Antonio, Texas  78284-7811
CCOP - Atlanta Regional Atlanta, Georgia  30342-1701
CCOP - Kansas City Kansas City, Missouri  64131
CCOP - Southern Nevada Cancer Research Foundation Las Vegas, Nevada  89106
CCOP - Christiana Care Health Services Wilmington, Delaware  19899
CCOP - Mount Sinai Medical Center Miami Beach, Florida  33140
CCOP - North Shore University Hospital Manhasset, New York  11030
CCOP - Southeast Cancer Control Consortium Winston-Salem, North Carolina  27104-4241
MBCCOP - Massey Cancer Center Richmond, Virginia  23298-0037
CCOP - Illinois Oncology Research Association Peoria, Illinois  61602
CCOP - Carle Cancer Center Urbana, Illinois  61801
CCOP - Iowa Oncology Research Association Des Moines, Iowa  50309-1016
Beth Israel Deaconess Medical Center Boston, Massachusetts  02215
CCOP - Kalamazoo Kalamazoo, Michigan  49007-3731
CCOP - Metro-Minnesota Saint Louis Park, Minnesota  55416
CCOP - Northern New Jersey Hackensack, New Jersey  07601
Bergan Mercy Medical Center Omaha, Nebraska  68124
St. Vincent Hospital and Health Care Center Indianapolis, Indiana  46260
Yale Comprehensive Cancer Center New Haven, Connecticut  06520-8028
Hinsdale Hematology Oncology Associates Hinsdale, Illinois  60521
Methodist Cancer Center at Methodist Hospital Indianapolis, Indiana  46202
Saint Anthony Memorial Health Centers Michigan City, Indiana  46360
CCOP - Michigan Cancer Research Consortium Ann Arbor, Michigan  48106
St. John Macomb Hospital Warren, Michigan  48093
CCOP - Duluth Duluth, Minnesota  55805
Hennepin County Medical Center - Minneapolis Minneapolis, Minnesota  55415
Geisinger Medical Center Danville, Pennsylvania  17822-0001
Penn State Cancer Institute at Milton S. Hershey Medical Center Hershey, Pennsylvania  17033-0850
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Medical College of Wisconsin Cancer Center Milwaukee, Wisconsin  53226
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MD Anderson Cancer Center Orlando Orlando, Florida  32806
CCOP - Cedar Rapids Oncology Project Cedar Rapids, Iowa  52403-1206
Siouxland Hematology-Oncology Sioux City, Iowa  51101-1733
CCOP - Ochsner New Orleans, Louisiana  70121
Massachusetts General Hospital Cancer Center Boston, Massachusetts  02114
CCOP - Merit Care Hospital Fargo, North Dakota  58122
Rapid City Regional Hospital Rapid City, South Dakota  57709
CCOP - Sioux Community Cancer Consortium Sioux Falls, South Dakota  57105-1080
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NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York  10016
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Providence Saint Joseph Medical Center - Burbank Burbank, California  91505
Mount Diablo Medical Center Concord, California  94524-4110
Kaiser Permanente Medical Center - Los Angeles Los Angeles, California  90027
CCOP - Santa Rosa Memorial Hospital Santa Rosa, California  95403
Northwest Community Hospital Arlington Heights, Illinois  60005
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Ingalls Memorial Hospital Harvey, Illinois  60426
Lutheran General Cancer Care Center Park Ridge, Illinois  60068
CCOP - Central Illinois Springfield, Illinois  62526
Wendt Regional Cancer Center of Finley Hospital Dubuque, Iowa  52001
Greater Baltimore Medical Center and Cancer Center Baltimore, Maryland  21204
Marquette General Hospital Marquette, Michigan  49855
CCOP - Cancer Research for the Ozarks Springfield, Missouri  65807
CCOP - Montana Cancer Consortium Billings, Montana  59101
Newark Beth Israel Medical Center Newark, New Jersey  07112
Community Medical Center Toms River, New Jersey  08755
Akron General Medical Center Akron, Ohio  44302
CCOP - Columbus Columbus, Ohio  43206
CCOP - Dayton Kettering, Ohio  45429
Delaware County Memorial Hospital Drexel Hill, Pennsylvania  19026
Albert Einstein Cancer Center Philadelphia, Pennsylvania  19141
Reading Hospital and Medical Center Reading, Pennsylvania  19612-6052
Grand View Hospital Sellersville, Pennsylvania  18960
Harrington Cancer Center Amarillo, Texas  79106
Joe Arrington Cancer Research and Treatment Center Lubbock, Texas  79410-1894
Green Mountain Oncology Group Rutland, Vermont  05701
Martha Jefferson Hospital Charlottesville, Virginia  22901
University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin  53792
CCOP - Western Regional, Arizona Phoenix, Arizona  85006-2726
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center Orange, California  92868
MBCCOP - University of Illinois at Chicago Chicago, Illinois  60612
CCOP - Evanston Evanston, Illinois  60201
CCOP - Northern Indiana CR Consortium South Bend, Indiana  46601
Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa  52242-1002
CCOP - Grand Rapids Grand Rapids, Michigan  49503
Keesler Medical Center - Keesler Air Force Base Keesler AFB, Mississippi  39534-2576
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina  27599-7570
Charles M. Barrett Cancer Center at University Hospital Cincinnati, Ohio  45267-0526
CCOP - Columbia River Oncology Program Portland, Oregon  97225
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Philadelphia, Pennsylvania  19107
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center Nashville, Tennessee  37232-2516
CCOP - Scott and White Hospital Temple, Texas  76508
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland  21231-2410
Baptist Regional Cancer Institute - Jacksonville Jacksonville, Florida  32207
St. Barnabas Medical Center Livingston, New Jersey  07039
Kaiser Permanente Center for Health Research Portland, Oregon  97227-1098
Cleveland Clinic Taussig Cancer Center Cleveland, Ohio  44195
MBCCOP - Gulf Coast Mobile, Alabama  36688
USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California  90033-0804
MBCCOP - LSU Health Sciences Center New Orleans, Louisiana  70112
CCOP - St. Louis-Cape Girardeau Saint Louis, Missouri  63141
CCOP - Virginia Mason Research Center Seattle, Washington  98101
CCOP - Northwest Tacoma, Washington  98405-0986
Naval Medical Center - San Diego San Diego, California  92134-3202
Kaiser Permanente Medical Center - Vallejo Vallejo, California  94589
Hartford Hospital Hartford, Connecticut  06102-5037
Rockford Clinic Rockford, Illinois  61103
Baptist Hospital East - Louisville Louisville, Kentucky  40207
Eastern Maine Medical Center Bangor, Maine  04401
Franklin Square Hospital Center Baltimore, Maryland  21237
Genesee Surgical Associates Rochester, New York  14607
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. Syracuse, New York  13217
CCOP - Oklahoma Tulsa, Oklahoma  74136
Allegheny General Hospital Pittsburgh, Pennsylvania  15212-4772
University of Texas Health Center at Tyler Tyler, Texas  75708
Virginia Oncology Associates - Newport News Newport News, Virginia  23606
Oncology and Hematology Associates of Southwest Virginia, Inc. Roanoke, Virginia  24014
Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Providence Alaska Medical Center Anchorage, Alaska  99508
Monmouth Medical Center Long Branch, New Jersey  07740-6395
South Jersey Regional Cancer Center Millville, New Jersey  08332
Cancer Institute of New Jersey New Brunswick, New Jersey  08901
Atlantic City Medical Center Pomona, New Jersey  08240
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Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts  02115
University of Massachusetts Memorial Medical Center - University Campus Worcester, Massachusetts  01655
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Queens Cancer Center of Queens Hospital Jamaica, New York  11432
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Capital Health System at Mercer Trenton, New Jersey  08607
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St. Vincent Mercy Medical Center Toledo, Ohio  43608
CCOP - Colorado Cancer Research Program, Incorporated Denver, Colorado  80224
Hillman Cancer Center at University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania  15236
Arizona Cancer Center at University of Arizona Health Sciences Center Tucson, Arizona  85724
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock, Arkansas  72205
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas  66160-7353
Markey Cancer Center at University of Kentucky Chandler Medical Center Lexington, Kentucky  40536-0084
Tulane Cancer Center at Tulane University Hospital and Clinic New Orleans, Louisiana  70112
Cancer Research Center at Boston Medical Center Boston, Massachusetts  02118
Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan  48202
Herbert Irving Comprehensive Cancer Center at Columbia University New York, New York  10032
Cancer Institute at Oregon Health and Science University Portland, Oregon  97201-3098
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Palmetto Richland Memorial Hospital Columbia, South Carolina  29203
Thompson Cancer Survival Center Knoxville, Tennessee  37916
Northeast Arkansas Clinic Jonesboro, Arkansas  72401-3125
James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky  40202
Maine Center for Cancer Medicine and Blood Disorders - Scarborough Scarborough, Maine  04074
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Charles A. Sammons Cancer Center Dallas, Texas  75246
St. John's Regional Health Center Springfield, Missouri  65804
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Hospital of St. Raphael New Haven, Connecticut  06511
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Valley Hospital Ridgewood, New Jersey  07450
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Mercy Fitzgerald Hospital Darby, Pennsylvania  19023
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Toledo Hospital Toledo, Ohio  43606
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Chester County Hospital West Chester, Pennsylvania  19380
Comprehensive Cancer Institute Huntsville, Alabama  35801
Torrance Memorial Medical Center Torrance, California  90505
Oncology Institute of Greater Lafayette Lafayette, Indiana  47904
St. Elizabeth Medical Center Edgewood, Kentucky  41017
NSMC Cancer Center Peabody, Massachusetts  01960
Somerset Medical Center Somerville, New Jersey  08876
Cancer Center at Christ Hospital Cincinnati, Ohio  45219
Parma Community General Hospital Parma, Ohio  44129
Vermont Cancer Center at University of Vermont Burlington, Vermont  05405-0075
Holland Community Hospital Holland, Michigan  49423
Munson Medical Center Traverse City, Michigan  49684
Kalispell Regional Medical Center Kalispell, Montana  59901
St. Joseph Hospital Community Cancer Center Bellingham, Washington  98225
Olympic Hematology and Oncology Bremerton, Washington  98310
Lombardi Cancer Center at Georgetown University Medical Center Washington, District of Columbia  20007
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore, Maryland  21201
New Hampshire Oncology-Hematology, PA - Hooksett Hooksett, New Hampshire  03106
Swedish-American Regional Cancer Center Rockford, Illinois  61104-2315
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Baystate Regional Cancer Program at Baystate Medical Center Springfield, Massachusetts  01107
University Hospital at State University of New York - Upstate Medical University Syracuse, New York  13210
Mission Hospitals Asheville, North Carolina  28801
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina Greenville, North Carolina  27858-4354
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Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois  60611
Cancer Center of Santa Barbara Santa Barbara, California  93105
Rockwood Clinic P.S. Spokane, Washington  99202
St. Francis Hospital and Medical Center Hartford, Connecticut  06105
Todd Cancer Institute at Long Beach Memorial Medical Center Long Beach, California  90801
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Lakeland Regional Cancer Center at Lakeland Regional Medical Center Lakeland, Florida  33805
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California Pacific Medical Center - California Campus San Francisco, California  94118
Poudre Valley Hospital Fort Collins, Colorado  80524
St. Mary-Corwin Regional Medical Center Pueblo, Colorado  81004
Beebe Medical Center Lewes, Delaware  19958
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Jupiter, Florida  33458
Edward Hospital Cancer Center Naperville, Illinois  60540
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
Ochsner Clinic of Baton Rouge Baton Rouge, Louisiana  708169990
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
Hattiesburg Clinic, P.A. Hattiesburg, Mississippi  39401
Creighton University Medical Center Omaha, Nebraska  68131-2197
Booker Cancer Center at Riverview Medical Center Red Bank, New Jersey  07701
Blanchard Valley Medical Associates Findlay, Ohio  45840
Fremont Memorial Hospital Fremont, Ohio  43420
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Firelands Regional Medical Center Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Fulton County Health Center Wauseon, Ohio  43567
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Southwestern Vermont Regional Cancer Center Bennington, Vermont  05201
Mountainview Medical Berlin, Vermont  05602
Kaiser Permanente Medical Group Los Angeles, California  90027
Penrose Cancer Center Colorado Springs, Colorado  80933
Lawrence and Memorial Hospital New London, Connecticut  06320
Northwestern Connecticut Oncology-Hematology Associates Torrington, Connecticut  06790
Edward H. Kaplan MD and Associates Skokie, Illinois  60076
McFarland Clinic, P.C. Ames, Iowa  50010
Ottumwa Regional Health Center Ottumwa, Iowa  52501
Anne Arundel Medical Center Annapolis, Maryland  21401
Rice Memorial Hospital Willmar, Minnesota  56201
Alegent Health - Immanuel Medical Center Omaha, Nebraska  68122
St. Charles Hospital Oregon, Ohio  43616
Lancaster General Hospital Lancaster, Pennsylvania  17604-3555
Pottstown Memorial Regional Cancer Center Pottstown, Pennsylvania  19464
UW Cancer Center Wausau Hospital Wausau, Wisconsin  54401
CCOP - Mayo Clinic Scottsdale Oncology Program Scottsdale, Arizona  85259
Mills-Peninsula Health Services Burlingame, California  94010
Leavey Cancer Center at Northridge Hospital Medical Center Northridge, California  91325
Palo Alto Medical Foundation Palo Alto, California  94301
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Mercy Cancer Center at Mercy Medical Center - North Iowa Mason City, Iowa  50401
Battle Creek Health System Battle Creek, Michigan  49017
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Cancer Center at the Good Samaritan Health Systems Kearney, Nebraska  68847
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Hematology-Oncology Associates, PC Albuquerque, New Mexico  87106
Lovelace Medical Center at Lovelace Sandia Health System Albuquerque, New Mexico  87108
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital Cooperstown, New York  13326
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Medical College of Ohio Cancer Institute Toledo, Ohio  43614
Toledo Clinic, Incorporated Toledo, Ohio  43623
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital Allentown, Pennsylvania  18105
Cancer Center at Paoli Memorial Hospital Paoli, Pennsylvania  19301
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut  06360
Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas Encinitas, California  92023
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma  73126
University of Minnesota Minneapolis, Minnesota  55455
Palm Beach Cancer Institute West Palm Beach, Florida  33401
Providence Cancer Institute at Providence Hospital Southfield, Michigan  48075
University of Miami Sylvester Cancer Center Miami, Florida  33136
John H. Stroger, Jr. Hospital of Cook County Chicago, Illinois  60612-9985
Community Hospital Munster, Indiana  46321
Norton Healthcare Cancer Center Louisville, Kentucky  40202-5070
New York Oncology Hematology, P.C. - Albany Regional Cancer Center Albany, New York  12208
Charles R. Wood Foundation Cancer Center at Glens Falls Hospital Glens Falls, New York  12801
Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis Memphis, Tennessee  38146
Sutter Breast Cancer Group Sacramento, California  95819-5156
Huntington Cancer Center at Huntington Hospital Pasadena, California  91105
St. John's Hospital Springfield, Illinois  62701
Watson Clinic Lakeland, Florida  33805
Baton Rouge General Medical Center Baton Rouge, Louisiana  70821-2511
Genesys Regional Medical Center Grand Blanc, Michigan  48439-8066
Sacred Heart Hospital Allentown, Pennsylvania  18102
Aurora Sinai Medical Center Milwaukee, Wisconsin  53201-0342
St. Joseph Hospital Regional Cancer Center - Orange Orange, California  92868-3849
Southern New Hampshire Medical Center Nashua, New Hampshire  03061-2014
Comprehensive Cancer Center at Our Lady of Mercy Medical Center Bronx, New York  10466
Flower Hospital - ProMedica Health System Sylvania, Ohio  43560
Easton Hospital Easton, Pennsylvania  18042
Southwest Cancer and Research Center at University Medical Center Lubbock, Texas  79415-3364
Enloe Cancer Center at Enloe Medical Center Chico, California  95926
Caritas Norwood Hospital Norwood, Massachusetts  02062
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Bethesda North Hospital Cincinnati, Ohio  45242
Community Cancer Center at Rutland Regional Medical Center Rutland, Vermont  05701
Ball Memorial Hospital Cancer Center Muncie, Indiana  47303-3499
Regional Cancer Center - Erie Erie, Pennsylvania  16505
Siteman Cancer Center Saint Louis, Missouri  63110
Breast Associates Fayetteville, Arkansas  72703
Surgical Associates Fort Smith, Arkansas  72917
Kaiser Permanente Medical Center - Anaheim/Orange County Anaheim, California  92805
Kaiser Permanente Medical Center - Baldwin Park Baldwin Park, California  91706
Kaiser Permanente Medical Center - Bellflower Bellflower, California  90706
Corona Regional Medical Center Corona, California  92882-3400
Kaiser Permanente Medical Center - Fontana Fontana, California  92335
Crosson Cancer Center at St. Jude Medical Center Fullerton, California  92835
Glendale Memorial Hospital Comprehensive Cancer Center Glendale, California  91204
Oncology/Hematology Associates Granada Hills, California  91344
Marin General Hospital Cancer Institute Greenbrae, California  94904
Kaiser Permanente Medical Center - Harbor City Harbor City, California  90710
Hemet Valley Medical Center Hemet, California  92543
Valley Tumor Medical Group Lancaster, California  93534
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach Long Beach, California  90813
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center Los Angeles, California  90033
Kaiser Foundation Hospital - West Los Angeles Los Angeles, California  90034
Mission Cancer Center at Mission Hospital Mission Viejo, California  92691
Sutter Gould Medical Foundation Modesto, California  95353
Breast Health Center Oceanside, California  92056
Ventura Hematology - Oncology Specialists - Oxnard Oxnard, California  93030
Wilshire Oncology Medical Group, Incorporated - Pomona Pomona, California  91767-3021
North Valley Breast Clinic Redding, California  96001
Kaiser Permanente Medical Center - Riverside Riverside, California  92505
Sutter Roseville Medical Center Roseville, California  95661
Santa Clarita Valley Cancer Center - UCLA Valencia, California  91355
Kaiser Permanente Medical Cener - Woodland Hills Woodland Hills, California  91365-4084
Manchester Memorial Hospital Manchester, Connecticut  06040-4188
Midstate Medical Center Meriden, Connecticut  06451
Hematology Oncology, P.C. Stamford, Connecticut  06902
Windham Community Memorial Hospital Williamantic, Connecticut  06226
Nanticoke Memorial Hospital Seaford, Delaware  19973
Providence Hospital Washington, District of Columbia  20017
Washington Hospital Center Washington, District of Columbia  20010
JFK Medical Center Atlantis, Florida  33462
St. Vincent's Medical Center Jacksonville, Florida  32203
Florida Hospital Medical Center Orlando, Florida  32803-1273
West Florida Regional Medical Center Pensacola, Florida  32514-6088
Cancer Research Network Inc. Plantation, Florida  33324
Clinical Research Center of South Florida Stuart, Florida  34996
Medical College of Georgia Augusta, Georgia  30912
Cancer Care and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405-6013
Rush Copley Medical Center Aurora, Illinois  60504-4206
Our Lady of the Resurrection Medical Center Chicago, Illinois  60634
Rush Cancer Institute at Rush University Medical Center Chicago, Illinois  60612
Resurrection Medical Center Chicago, Illinois  60631
Sherman Hospital Elgin, Illinois  60120-2198
St. Francis Hospital Evanston, Illinois  60202
Advocate South Suburban Hospital Hazel Crest, Illinois  60429
Evanston Northwestern Health Care - Highland Park Hospital Highland Park, Illinois  60035-2497
Joliet Oncology Hematology Associates, Limited - Joliet Joliet, Illinois  60435
Mid-Illinois Hematology-Oncology Associates Normal, Illinois  61761
Saint James Hospital and Health Centers Comprehensive Cancer Institute Olympia Fields, Illinois  60461
Trinity Medical Center - West Rock Island, Illinois  61201
Memorial Medical Center Springfield, Illinois  62781
Center for Cancer Care at Goshen Health System Goshen, Indiana  46526
Indiana Regional Cancer Center Indianapolis, Indiana  46256
Indiana Community Cancer Care, Incorporated Indianapolis, Indiana  46202
Medical Associates Clinton, Iowa  52732-5031
Jennie Edmundson Memorial Hospital Council Bluffs, Iowa  51503
Cedar Valley Medical Specialists, P.C. Waterloo, Iowa  50701
King's Daughters Medical Center Ashland, Kentucky  41101
HCA Kings Daughters Memorial Hospital Frankfort, Kentucky  40601
Cancer Care Specialists Houma, Louisiana  70360
Cancer Treatment Center at Christus Schumpert St. Mary Place Shreveport, Louisiana  71101
Goodall Hospital Sanford, Maine  04073
Frederick Memorial Hospital Regional Cancer Therapy Center Frederick, Maryland  21701
Harvard Vanguard Medical Associates - Kenmore Boston, Massachusetts  02215
Saint Anne's Hospital Fall River, Massachusetts  02721
Berkshire Physicians and Surgeons, P.C. Pittsfield, Massachusetts  01201
Jordan Hospital Club Cancer Center Plymouth, Massachusetts  02360
Bay Diagnostic Center for Women Bay City, Michigan  48708
Community Health Center of Branch County Coldwater, Michigan  49036
Oakwood Hospital and Medical Center Dearborn, Michigan  48123-2500
Flint Hematology Oncology Flint, Michigan  48532
Center for Hematology/Oncology Jackson, Michigan  49201
Michigan State University Department of Surgery Lansing, Michigan  48912
Lapeer Regional Hospital Lapeer, Michigan  48446
Mercy Memorial Hospital, Corporation Monroe, Michigan  48161-0067
Community Cancer Care Specialist Mount Clemens, Michigan  48043
Memorial Healthcare Owosso, Michigan  48867
Blue Water Oncology PC, Port Huron Port Huron, Michigan  48060
Saint Mary's Seton Cancer Institute Saginaw, Michigan  48601
St. Luke's Medical Clinic Duluth, Minnesota  55805
Minnesota Cooperative Group Program Minneapolis, Minnesota  55407
Coast Oncology/Hematology, P.L.L.C. Biloxi, Mississippi  39530-4239
Mid Delta Family Practice Cleveland, Mississippi  38732
Jackson Oncology Associates, PLLC Jackson, Mississippi  39202
North Mississippi Hematology and Oncology Associates, Limited Tupelo, Mississippi  38801
St. John's Regional Medical Center Joplin, Missouri  64804
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
Phelps County Regional Medical Center Rolla, Missouri  65401
Midwest Hematology Oncology Group, Inc. Saint Louis, Missouri  63109
Missouri Cancer Care, P.C. - St. Charles St. Charles, Missouri  63301
Ozarks Medical Center West Plains, Missouri  65775
Montana Cancer Institute - Benefis Healthcare Great Falls, Montana  59405
Saint Francis Medical Center Grand Island, Nebraska  68802
Englewood Hospital and Medical Center Englewood, New Jersey  07631
Underwood Memorial Hospital Woodbury, New Jersey  08096
New Mexico Oncology-Hematology Consultants, Limited Albuquerque, New Mexico  87109
New Mexico Cancer Care Associates Santa Fe, New Mexico  87505-7670
New York Oncology Hematology, P.C. - Latham Latham, New York  12110-0610
St. Francis Hospital and Health Centers Poughkeepsie, New York  12601
Gynecologic Oncology Associates Rochester, New York  14620
University Hospital - Stony Brook Stony Brook, New York  11794-8174
Gaston Hematology and Oncology Gastonia, North Carolina  28054
Southeastern Medical Oncology Center Goldsboro, North Carolina  27534
Cornerstone Surgery High Point, North Carolina  27262
Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center Raleigh, North Carolina  27607
Cancer Center at Iredell Memorial Hospital Statesville, North Carolina  28687-1828
Forsyth Medical Center Winston-Salem, North Carolina  27103
Quain & Ramstad Clinic Bismarck, North Dakota  58501
Kaiser Permanente Cleveland, Ohio  44120
Fairview Hospital Cleveland, Ohio  44111
Cleveland Clinic Health System STAR BCPT Warrensville Heights, Ohio  44122
Muskogee Regional Medical Center Muskogee, Oklahoma  74401
Frank C. Love Cancer Institute at St. Anthony Hospital Oklahoma City, Oklahoma  73101
Mercy Health Center Oklahoma City, Oklahoma  73120
Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center Oklahoma City, Oklahoma  73109
St. Charles Medical Center Bend, Oregon  97701
Bon Secours-Holy Family Health System Altoona, Pennsylvania  16602
Doylestown Hospital Doylestown, Pennsylvania  18901
Ephrata Community Hopital Ephrata, Pennsylvania  17522-1002
Pinnacle Health Regional Cancer Center at Pinnacle Health System Harrisburg, Pennsylvania  17105-8700
Mercy Community Hospital Havertown, Pennsylvania  19083
Saint Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Riddle Memorial Hospital Media, Pennsylvania  19063
Mercy Hospital of Philadelphia Philadelphia, Pennsylvania  19143
Chestnut Hill Healthcare Philadelphia, Pennsylvania  19118
Frankford Hospital Philadelphia, Pennsylvania  19114
Pennsylvania Oncology Hematology Associates Philadelphia, Pennsylvania  19107
Crozer-Chester Medical Center Upland, Pennsylvania  19013
AnMed Health Anderson, South Carolina  29621
Roper St. Francis Healthcare - Roper Hospital Charleston, South Carolina  29401
McLeod Regional Medical Center Florence, South Carolina  29501
Cancer Centers of the Carolinas - Eastside Greenville, South Carolina  29601
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee  37662
U.T. Cancer Institute at University of Tennessee Medical Center Knoxville, Tennessee  37920-2911
MBCCOP - Meharry Medical College - Nashville Nashville, Tennessee  37208-3599
Hendrick Cancer Center Abilene, Texas  79601-2316
Julie and Ben Rogers Cancer Center Beaumont, Texas  77701
Methodist Dallas Medical Center Dallas, Texas  75265-5999
Presbyterian Hospital of Dallas Dallas, Texas  75231
Providence Memorial Hospital El Paso, Texas  79902
Harris Methodist Fort Worth Fort Worth, Texas  76104
Texas Cancer Institute at St. Luke's Episcopal Hospital Houston, Texas  77030
Baylor Medical Center at Garland Irving, Texas  75061
Sanchez Cancer Center Laredo, Texas  78041
Memorial Health System of East Texas Lufkin, Texas  75902
Baylor/Richardson Cancer Center Richardson, Texas  75080
Danville Hematology and Oncology, Incorporated Danville, Virginia  24541
Cancer Center of the Piedmont, Inc. Danville, Virginia  24541
Henrico Doctors' Hospital - Parham Campus Richmond, Virginia  23229
Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus Everett, Washington  98258-0000
Cancer Care Northwest - Spokane North Spokane, Washington  99207
Yakima Regional Cancer Care Center Yakima, Washington  89802
David Lee Cancer Center at Charleston Area Medical Center Charleston, West Virginia  25304-1297
Oncology Alliance, S.C. Milwaukee, Wisconsin  53215