A Phase I-II Study of Pentostatin With Cyclophosphamide for Previously Treated Patients With Intermediate and High-Risk Chronic Lymphocytic Leukemia

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Intermediate- or high-risk chronic lymphocytic leukemia (CLL) as defined by the
three-stage Rai system

- Rai intermediate disease must be active disease (including weight loss, fatigue,
fevers, evidence of progressive marrow failure, splenomegaly, progressive
lymphadenopathy, and progressive lymphocytosis with a rapid doubling time)

- Other low-grade B-cell neoplasms, including small lymphocytic lymphoma (and its
variants), Waldenstrom's macroglobulinemia, and follicular lymphoma allowed

- Autoimmune hemolytic anemia or autoimmune thrombocytopenia allowed regardless of
disease stage

- B-cells demonstrated by immunophenotypic (or immunohistochemical) analysis of the
malignant lymphocytes

- Must be previously treated

- For CLL, absolute lymphocytosis in the blood at least 5,000 lymphocytes/mm^3 OR

- Bone marrow lymphocytosis at least 30% of all nucleated cells

- No Rai intermediate-risk disease that meets the criteria of Montserrat "smoldering
leukemia" NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been
adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace
the former terminology of "low", "intermediate", or "high" grade lymphoma. However,
this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- Karnofsky 60-100%

Life expectancy:

- More than 4 weeks

Hematopoietic:

- See Disease Characteristics

Hepatic:

- Bilirubin no greater than 2.0 mg/dL

Renal:

- Creatinine no greater than 2.0 mg/dL

Other:

- No active infections requiring systemic antibiotics

- Not pregnant or nursing

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- At least 4 weeks since prior biologic therapy

- Concurrent intravenous immunoglobulin allowed

- Concurrent epoetin alfa allowed

Chemotherapy:

- At least 4 weeks since prior chemotherapy

- No other concurrent chemotherapy

Endocrine therapy:

- Concurrent prednisone therapy allowed as long as dose is stable or decreasing over
the past 4 weeks

- No increase in prednisone therapy while on study

Radiotherapy:

- At least 4 weeks since prior radiotherapy

- No concurrent radiotherapy

Surgery:

- Not specified