Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed metastatic or recurrent squamous cell
carcinoma of the oral cavity, lip, hypopharynx, oropharynx, nasopharynx, paranasal
sinuses, nasal cavity, nostril, or larynx that is not curable by surgery or radiation
therapy Must have one or more measurable indicator lesions Bone metastases, brain
metastases, elevated enzyme levels and lesions on radionuclide scans are not acceptable as
the sole parameters of measurable disease

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life
expectancy: Not specified Hematopoietic: WBC greater than 4,000/mm3 Platelet count greater
than 100,000/mm3 Hepatic: Bilirubin less than 1.5 mg/dL Transaminases (SGOT/SGPT) less
than 2.5 times upper limit of normal Renal: Creatinine less than 1.5 mg/dL OR Creatinine
clearance at least 50 mL/min Cardiovascular: No unstable cardiac rhythm Other: No active
infection requiring antibiotics No concurrent medical condition that makes participation
in this study medically unsafe No other prior malignancy in the last 2 years except basal
or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, or
metachronous/synchronous epidermoid/squamous cell cancers of the head and neck Not
pregnant or nursing Effective contraception required of all fertile patients

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: One prior
chemotherapy regimen as part of a locoregional treatment (e.g., induction/concomitant)
allowed, either as primary treatment or as therapy for locoregional relapse, if relapse
occurred more than 6 months later No other prior chemotherapy Prior chemoprevention agents
(e.g., cisretinoic acid or other vitamin analogues) allowed Endocrine therapy: Not
specified Radiotherapy: See Disease Characteristics At least 4 weeks since prior
radiotherapy No prior radiotherapy to more than 50% of bone marrow-bearing bones Surgery:
See Disease Characteristics