Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed, Stage IV neuroblastoma in second or
subsequent complete remission, defined by the complete disappearance of all evidence of
tumor on the following: Physical examination Second-look surgery Bone scan Bone marrow
aspiration and biopsy Chest x-ray CT MIBG Urinary catecholamines If marrow is infiltrated
by tumor, complete elimination of tumor cells from the marrow compartment must be
demonstrated by histology and immunofluorescence (based on simultaneous bone marrow
aspiration and biopsy samples from at least 4 separate sites)

PATIENT CHARACTERISTICS: Age: Under 18 Performance status: Not specified Life expectancy:
Greater than 12 weeks Hematopoietic: Grade 4 cytopenias allowed Grade 3 marrow hypoplasia
allowed Hepatic: Not specified Renal: No renal dysfunction worse than grade 3
Cardiovascular: No cardiac dysfunction worse than grade 2 Pulmonary: No pulmonary
dysfunction worse than grade 2 Other: No neurologic dysfunction worse than grade 2 Hearing
deficit allowed

PRIOR CONCURRENT THERAPY: Prior murine antibody therapy allowed provided circulating HAMA
titer is less than 1,000 U/mL serum by ELISA